Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology
Zika virus infection during pregnancy can result in birth defects, but underlying pathogenesis at the maternal-fetal interface is unclear. Here, the authors use non-invasive in vivo imaging of Zika-infected rhesus macaques and show that infection results in abnormal oxygen transport across the place...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2018-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-02499-9 |
| _version_ | 1818841485147111424 |
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| author | Alec J. Hirsch Victoria H. J. Roberts Peta L. Grigsby Nicole Haese Matthias C. Schabel Xiaojie Wang Jamie O. Lo Zheng Liu Christopher D. Kroenke Jessica L. Smith Meredith Kelleher Rebecca Broeckel Craig N. Kreklywich Christopher J. Parkins Michael Denton Patricia Smith Victor DeFilippis William Messer Jay A. Nelson Jon D. Hennebold Marjorie Grafe Lois Colgin Anne Lewis Rebecca Ducore Tonya Swanson Alfred W. Legasse Michael K. Axthelm Rhonda MacAllister Ashlee V. Moses Terry K. Morgan Antonio E. Frias Daniel N. Streblow |
| author_facet | Alec J. Hirsch Victoria H. J. Roberts Peta L. Grigsby Nicole Haese Matthias C. Schabel Xiaojie Wang Jamie O. Lo Zheng Liu Christopher D. Kroenke Jessica L. Smith Meredith Kelleher Rebecca Broeckel Craig N. Kreklywich Christopher J. Parkins Michael Denton Patricia Smith Victor DeFilippis William Messer Jay A. Nelson Jon D. Hennebold Marjorie Grafe Lois Colgin Anne Lewis Rebecca Ducore Tonya Swanson Alfred W. Legasse Michael K. Axthelm Rhonda MacAllister Ashlee V. Moses Terry K. Morgan Antonio E. Frias Daniel N. Streblow |
| author_sort | Alec J. Hirsch |
| collection | DOAJ |
| description | Zika virus infection during pregnancy can result in birth defects, but underlying pathogenesis at the maternal-fetal interface is unclear. Here, the authors use non-invasive in vivo imaging of Zika-infected rhesus macaques and show that infection results in abnormal oxygen transport across the placenta. |
| first_indexed | 2024-12-19T04:26:49Z |
| format | Article |
| id | doaj.art-b27991f416df40acb0fbda1482c193c4 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:26:49Z |
| publishDate | 2018-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b27991f416df40acb0fbda1482c193c42022-12-21T20:36:00ZengNature PortfolioNature Communications2041-17232018-01-019111510.1038/s41467-017-02499-9Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathologyAlec J. Hirsch0Victoria H. J. Roberts1Peta L. Grigsby2Nicole Haese3Matthias C. Schabel4Xiaojie Wang5Jamie O. Lo6Zheng Liu7Christopher D. Kroenke8Jessica L. Smith9Meredith Kelleher10Rebecca Broeckel11Craig N. Kreklywich12Christopher J. Parkins13Michael Denton14Patricia Smith15Victor DeFilippis16William Messer17Jay A. Nelson18Jon D. Hennebold19Marjorie Grafe20Lois Colgin21Anne Lewis22Rebecca Ducore23Tonya Swanson24Alfred W. Legasse25Michael K. Axthelm26Rhonda MacAllister27Ashlee V. Moses28Terry K. Morgan29Antonio E. Frias30Daniel N. Streblow31The Vaccine & Gene Institute, Oregon Health and Science University (OHSU)Division of Reproductive & Developmental Sciences, ONPRCDivision of Reproductive & Developmental Sciences, ONPRCThe Vaccine & Gene Institute, Oregon Health and Science University (OHSU)Advanced Imaging Research Center, OHSUAdvanced Imaging Research Center, OHSUDepartment of Obstetrics & Gynecology, OHSUAdvanced Imaging Research Center, OHSUAdvanced Imaging Research Center, OHSUThe Vaccine & Gene Institute, Oregon Health and Science University (OHSU)Division of Reproductive & Developmental Sciences, ONPRCThe Vaccine & Gene Institute, Oregon Health and Science University (OHSU)The Vaccine & Gene Institute, Oregon Health and Science University (OHSU)The Vaccine & Gene Institute, Oregon Health and Science University (OHSU)The Vaccine & Gene Institute, Oregon Health and Science University (OHSU)The Vaccine & Gene Institute, Oregon Health and Science University (OHSU)The Vaccine & Gene Institute, Oregon Health and Science University (OHSU)Department of Molecular Microbiology & Immunology, OHSUThe Vaccine & Gene Institute, Oregon Health and Science University (OHSU)Division of Reproductive & Developmental Sciences, ONPRCNeuropathology, OHSUPathology Services Unit, Division of Comparative Medicine, ONPRCPathology Services Unit, Division of Comparative Medicine, ONPRCPathology Services Unit, Division of Comparative Medicine, ONPRCDivision of Pathobiology & Immunology, Oregon National Primate Research Center (ONPRC)Division of Pathobiology & Immunology, Oregon National Primate Research Center (ONPRC)Division of Pathobiology & Immunology, Oregon National Primate Research Center (ONPRC)Clinical Services Unit, Division of Comparative Medicine, ONPRCThe Vaccine & Gene Institute, Oregon Health and Science University (OHSU)Department of Obstetrics & Gynecology, OHSUDivision of Reproductive & Developmental Sciences, ONPRCThe Vaccine & Gene Institute, Oregon Health and Science University (OHSU)Zika virus infection during pregnancy can result in birth defects, but underlying pathogenesis at the maternal-fetal interface is unclear. Here, the authors use non-invasive in vivo imaging of Zika-infected rhesus macaques and show that infection results in abnormal oxygen transport across the placenta.https://doi.org/10.1038/s41467-017-02499-9 |
| spellingShingle | Alec J. Hirsch Victoria H. J. Roberts Peta L. Grigsby Nicole Haese Matthias C. Schabel Xiaojie Wang Jamie O. Lo Zheng Liu Christopher D. Kroenke Jessica L. Smith Meredith Kelleher Rebecca Broeckel Craig N. Kreklywich Christopher J. Parkins Michael Denton Patricia Smith Victor DeFilippis William Messer Jay A. Nelson Jon D. Hennebold Marjorie Grafe Lois Colgin Anne Lewis Rebecca Ducore Tonya Swanson Alfred W. Legasse Michael K. Axthelm Rhonda MacAllister Ashlee V. Moses Terry K. Morgan Antonio E. Frias Daniel N. Streblow Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology Nature Communications |
| title | Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology |
| title_full | Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology |
| title_fullStr | Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology |
| title_full_unstemmed | Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology |
| title_short | Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology |
| title_sort | zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology |
| url | https://doi.org/10.1038/s41467-017-02499-9 |
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