Morphological manifestations of irritable bowel syndrome
The article presents modern data on morphological changes in the intestinal mucosa in patients with irritable bowel syndrome. There were analyzed the studies of different years on the morphological manifestations of irritable bowel syndrome. It has been shown that this pathology has an unusual low-g...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Zaslavsky O.Yu.
2021-06-01
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| Series: | Gastroenterologìa |
| Subjects: | |
| Online Access: | http://gastro.zaslavsky.com.ua/article/view/233635 |
| _version_ | 1798032579387981824 |
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| author | Yu.M. Stepanov I.Ya. Budzak Yu.A. Gaidar |
| author_facet | Yu.M. Stepanov I.Ya. Budzak Yu.A. Gaidar |
| author_sort | Yu.M. Stepanov |
| collection | DOAJ |
| description | The article presents modern data on morphological changes in the intestinal mucosa in patients with irritable bowel syndrome. There were analyzed the studies of different years on the morphological manifestations of irritable bowel syndrome. It has been shown that this pathology has an unusual low-grade inflammation. Mast cells play an important role in these inflammatory disorders, they have an effect on motility disorders, visceral hypersensitivity and other pathogenetic factors of irritable bowel syndrome. Disorders of intercellular tight junctions in this category of patients were also analyzed. The role of proteins involved in intercellular contacts (occludin, claudin, ZO) has been characterized. An analysis of the studies investigating these disorders has been carried out. The article provides examples of the analysis of biopsies in patients with irritable bowel syndrome using various methods of their assessment. |
| first_indexed | 2024-04-11T20:14:58Z |
| format | Article |
| id | doaj.art-b27c285f2fd844c7947915edd37fb2dd |
| institution | Directory Open Access Journal |
| issn | 2308-2097 2518-7880 |
| language | English |
| last_indexed | 2024-04-11T20:14:58Z |
| publishDate | 2021-06-01 |
| publisher | Zaslavsky O.Yu. |
| record_format | Article |
| series | Gastroenterologìa |
| spelling | doaj.art-b27c285f2fd844c7947915edd37fb2dd2022-12-22T04:04:59ZengZaslavsky O.Yu.Gastroenterologìa2308-20972518-78802021-06-0155210811410.22141/2308-2097.55.2.2021.233635271273Morphological manifestations of irritable bowel syndromeYu.M. Stepanov0https://orcid.org/0000-0002-6721-2468I.Ya. Budzak1https://orcid.org/0000-0001-5370-8414Yu.A. Gaidar2https://orcid.org/0000-0001-8284-0908State Institution “Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine”, Dnipro, UkraineDnipro State Medical University, Dnipro, UkraineState Institution “Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine”, Dnipro, UkraineThe article presents modern data on morphological changes in the intestinal mucosa in patients with irritable bowel syndrome. There were analyzed the studies of different years on the morphological manifestations of irritable bowel syndrome. It has been shown that this pathology has an unusual low-grade inflammation. Mast cells play an important role in these inflammatory disorders, they have an effect on motility disorders, visceral hypersensitivity and other pathogenetic factors of irritable bowel syndrome. Disorders of intercellular tight junctions in this category of patients were also analyzed. The role of proteins involved in intercellular contacts (occludin, claudin, ZO) has been characterized. An analysis of the studies investigating these disorders has been carried out. The article provides examples of the analysis of biopsies in patients with irritable bowel syndrome using various methods of their assessment.http://gastro.zaslavsky.com.ua/article/view/233635irritable bowel syndrome, morphological diagnosis, low-grade inflammation, mast cells, tight junctions |
| spellingShingle | Yu.M. Stepanov I.Ya. Budzak Yu.A. Gaidar Morphological manifestations of irritable bowel syndrome Gastroenterologìa irritable bowel syndrome, morphological diagnosis, low-grade inflammation, mast cells, tight junctions |
| title | Morphological manifestations of irritable bowel syndrome |
| title_full | Morphological manifestations of irritable bowel syndrome |
| title_fullStr | Morphological manifestations of irritable bowel syndrome |
| title_full_unstemmed | Morphological manifestations of irritable bowel syndrome |
| title_short | Morphological manifestations of irritable bowel syndrome |
| title_sort | morphological manifestations of irritable bowel syndrome |
| topic | irritable bowel syndrome, morphological diagnosis, low-grade inflammation, mast cells, tight junctions |
| url | http://gastro.zaslavsky.com.ua/article/view/233635 |
| work_keys_str_mv | AT yumstepanov morphologicalmanifestationsofirritablebowelsyndrome AT iyabudzak morphologicalmanifestationsofirritablebowelsyndrome AT yuagaidar morphologicalmanifestationsofirritablebowelsyndrome |