Effect of a quality improvement program on compliance to the sepsis bundle in non-ICU patients: a multicenter prospective before and after cohort study
ObjectiveSepsis and septic shock are major challenges and economic burdens to healthcare, impacting millions of people globally and representing significant causes of mortality. Recently, a large number of quality improvement programs focused on sepsis resuscitation bundles have been instituted worl...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1215341/full |
| _version_ | 1797628935189561344 |
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| author | Gianpaola Monti Emanuele Rezoagli Emanuele Rezoagli Angelo Calini Alice Nova Silvia Marchesi Giovanni Nattino Greta Carrara Sergio Morra Francesca Cortellaro Monica Savioli Federico Capra Marzani Moreno Tresoldi Paolo Villa Stefano Greco Paolo Bonfanti Maria Grazia Spitoni Sergio Vesconi Pietro Caironi Roberto Fumagalli Roberto Fumagalli “Lotta alla Sepsi” Team Study Group M. Aceti M. Alborghetti E. Beck W. Bonalume M. Bornaghi S. Bosisio E. Brusa V. Canegrati R. Capra A. Cecchin S. Ciccone M. De Lucia G. Erhan C. Fabbri L. Ferrante N. Ferrari S. Franchini G. Gallotta P. Galotti P. Gavazzi D. Grassi M. Lattuada C. Lorini L. Manin G. Marchesi F. Margarito F. Martini M. Meo G. Minoja M. Ortolan M. Padovani M. Pecorino A. Quaini S. Quarteroni D. Radrizzani M. Ranzini T. Santambrogio V. Savojardo A. Sciascera G. Serra M. Tajè F. Tengattin T. Tira B. Tonolli R. Traficante M. Tresoldi E. Varisco M. Zarienato C. Zeroli |
| author_facet | Gianpaola Monti Emanuele Rezoagli Emanuele Rezoagli Angelo Calini Alice Nova Silvia Marchesi Giovanni Nattino Greta Carrara Sergio Morra Francesca Cortellaro Monica Savioli Federico Capra Marzani Moreno Tresoldi Paolo Villa Stefano Greco Paolo Bonfanti Maria Grazia Spitoni Sergio Vesconi Pietro Caironi Roberto Fumagalli Roberto Fumagalli “Lotta alla Sepsi” Team Study Group M. Aceti M. Alborghetti E. Beck W. Bonalume M. Bornaghi S. Bosisio E. Brusa V. Canegrati R. Capra A. Cecchin S. Ciccone M. De Lucia G. Erhan C. Fabbri L. Ferrante N. Ferrari S. Franchini G. Gallotta P. Galotti P. Gavazzi D. Grassi M. Lattuada C. Lorini L. Manin G. Marchesi F. Margarito F. Martini M. Meo G. Minoja M. Ortolan M. Padovani M. Pecorino A. Quaini S. Quarteroni D. Radrizzani M. Ranzini T. Santambrogio V. Savojardo A. Sciascera G. Serra M. Tajè F. Tengattin T. Tira B. Tonolli R. Traficante M. Tresoldi E. Varisco M. Zarienato C. Zeroli |
| author_sort | Gianpaola Monti |
| collection | DOAJ |
| description | ObjectiveSepsis and septic shock are major challenges and economic burdens to healthcare, impacting millions of people globally and representing significant causes of mortality. Recently, a large number of quality improvement programs focused on sepsis resuscitation bundles have been instituted worldwide. These educational initiatives have been shown to be associated with improvements in clinical outcomes. We aimed to evaluate the impact of a multi-faceted quality implementing program (QIP) on the compliance of a “simplified 1-h bundle” (Sepsis 6) and hospital mortality of severe sepsis and septic shock patients out of the intensive care unit (ICU).MethodsEmergency departments (EDs) and medical wards (MWs) of 12 academic and non-academic hospitals in the Lombardy region (Northern Italy) were involved in a multi-faceted QIP, which included educational and organizational interventions. Patients with a clinical diagnosis of severe sepsis or septic shock according to the Sepsis-2 criteria were enrolled in two different periods: from May 2011 to November 2011 (before-QIP cohort) and from August 2012 to June 2013 (after-QIP cohort).Measurements and main resultsThe effect of QIP on bundle compliance and hospital mortality was evaluated in a before–after analysis. We enrolled 467 patients in the before-QIP group and 656 in the after-QIP group. At the time of enrollment, septic shock was diagnosed in 50% of patients, similarly between the two periods. In the after-QIP group, we observed increased compliance to the “simplified rapid (1 h) intervention bundle” (the Sepsis 6 bundle – S6) at three time-points evaluated (1 h, 13.7 to 18.7%, p = 0.018, 3 h, 37.1 to 48.0%, p = 0.013, overall study period, 46.2 to 57.9%, p < 0.001). We then analyzed compliance with S6 and hospital mortality in the before- and after-QIP periods, stratifying the two patients’ cohorts by admission characteristics. Adherence to the S6 bundle was increased in patients with severe sepsis in the absence of shock, in patients with serum lactate <4.0 mmol/L, and in patients with hypotension at the time of enrollment, regardless of the type of admission (from EDs or MWs). Subsequently, in an observational analysis, we also investigated the relation between bundle compliance and hospital mortality by logistic regression. In the after-QIP cohort, we observed a lower in-hospital mortality than that observed in the before-QIP cohort. This finding was reported in subgroups where a higher adherence to the S6 bundle in the after-QIP period was found. After adjustment for confounders, the QIP appeared to be independently associated with a significant improvement in hospital mortality. Among the single S6 procedures applied within the first hour of sepsis diagnosis, compliance with blood culture and antibiotic therapy appeared significantly associated with reduced in-hospital mortality.ConclusionA multi-faceted QIP aimed at promoting an early simplified bundle of care for the management of septic patients out of the ICU was associated with improved compliance with sepsis bundles and lower in-hospital mortality. |
| first_indexed | 2024-03-11T10:46:14Z |
| format | Article |
| id | doaj.art-b27d078ef5c247ce8b0c627eec96cd43 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-11T10:46:14Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-b27d078ef5c247ce8b0c627eec96cd432023-11-14T04:56:28ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-11-011010.3389/fmed.2023.12153411215341Effect of a quality improvement program on compliance to the sepsis bundle in non-ICU patients: a multicenter prospective before and after cohort studyGianpaola Monti0Emanuele Rezoagli1Emanuele Rezoagli2Angelo Calini3Alice Nova4Silvia Marchesi5Giovanni Nattino6Greta Carrara7Sergio Morra8Francesca Cortellaro9Monica Savioli10Federico Capra Marzani11Moreno Tresoldi12Paolo Villa13Stefano Greco14Paolo Bonfanti15Maria Grazia Spitoni16Sergio Vesconi17Pietro Caironi18Roberto Fumagalli19Roberto Fumagalli20“Lotta alla Sepsi” Team Study GroupM. AcetiM. AlborghettiE. BeckW. BonalumeM. BornaghiS. BosisioE. BrusaV. CanegratiR. CapraA. CecchinS. CicconeM. De LuciaG. ErhanC. FabbriL. FerranteN. FerrariS. FranchiniG. GallottaP. GalottiP. GavazziD. GrassiM. LattuadaC. LoriniL. ManinG. MarchesiF. MargaritoF. MartiniM. MeoG. MinojaM. OrtolanM. PadovaniM. PecorinoA. QuainiS. QuarteroniD. RadrizzaniM. RanziniT. SantambrogioV. SavojardoA. SciasceraG. SerraM. TajèF. TengattinT. TiraB. TonolliR. TraficanteM. TresoldiE. VariscoM. ZarienatoC. ZeroliDepartment of Anesthesia and Intensive Care, ASST GOM Niguarda Ca’ Granda, Milan, ItalySchool of Medicine and Surgery, University of Milano-Bicocca, Monza, ItalyDepartment of Anesthesia and Intensive Care, Fondazione IRCCS San Gerardo dei Tintori, Monza, ItalyDepartment of Anesthesia and Intensive Care, ASST GOM Niguarda Ca’ Granda, Milan, ItalySchool of Medicine and Surgery, University of Milano-Bicocca, Monza, ItalyIntensiv och perioperativ vard, Skane Universitetssjukhus, Malmo, SwedenIstituto di ricerche farmacologiche Mario Negri IRCCS, Ranica, Bergamo, ItalyIstituto di ricerche farmacologiche Mario Negri IRCCS, Ranica, Bergamo, ItalyDepartment of Anesthesia and Intensive Care, ASST Ovest Milano, Legnano, ItalyAzienda Regionale Emergenza Urgenza (AREU), Milan, ItalyDepartment of Anesthesia, Intensive Care and Emergency, Fondazione IRCCSC Ca' Granda-Ospedale Maggiore Policlinico, Milan, ItalyDepartment of Anesthesia and Intensive Care, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy0Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Milan, Italy1Department of Emergency, ASST FBF - Sacco, Ospedale L. Sacco, Milan, Italy2Department of Anesthesia and Intensive Care, ASST Valle Olona, Ospedale Busto Arsitio, Busto Arsitio, Italy3Infectious Diseases, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy4ASST Bergamo Ovest, Ospedale di Treviglio e Caravaggio, Treviglio, ItalyDepartment of Anesthesia and Intensive Care, ASST GOM Niguarda Ca’ Granda, Milan, Italy5Department of Anesthesia and Intensive Care, AOU S. Luigi Gonzaga, Università degli Studi di Torino, Orbassano, ItalyDepartment of Anesthesia and Intensive Care, ASST GOM Niguarda Ca’ Granda, Milan, ItalySchool of Medicine and Surgery, University of Milano-Bicocca, Monza, ItalyObjectiveSepsis and septic shock are major challenges and economic burdens to healthcare, impacting millions of people globally and representing significant causes of mortality. Recently, a large number of quality improvement programs focused on sepsis resuscitation bundles have been instituted worldwide. These educational initiatives have been shown to be associated with improvements in clinical outcomes. We aimed to evaluate the impact of a multi-faceted quality implementing program (QIP) on the compliance of a “simplified 1-h bundle” (Sepsis 6) and hospital mortality of severe sepsis and septic shock patients out of the intensive care unit (ICU).MethodsEmergency departments (EDs) and medical wards (MWs) of 12 academic and non-academic hospitals in the Lombardy region (Northern Italy) were involved in a multi-faceted QIP, which included educational and organizational interventions. Patients with a clinical diagnosis of severe sepsis or septic shock according to the Sepsis-2 criteria were enrolled in two different periods: from May 2011 to November 2011 (before-QIP cohort) and from August 2012 to June 2013 (after-QIP cohort).Measurements and main resultsThe effect of QIP on bundle compliance and hospital mortality was evaluated in a before–after analysis. We enrolled 467 patients in the before-QIP group and 656 in the after-QIP group. At the time of enrollment, septic shock was diagnosed in 50% of patients, similarly between the two periods. In the after-QIP group, we observed increased compliance to the “simplified rapid (1 h) intervention bundle” (the Sepsis 6 bundle – S6) at three time-points evaluated (1 h, 13.7 to 18.7%, p = 0.018, 3 h, 37.1 to 48.0%, p = 0.013, overall study period, 46.2 to 57.9%, p < 0.001). We then analyzed compliance with S6 and hospital mortality in the before- and after-QIP periods, stratifying the two patients’ cohorts by admission characteristics. Adherence to the S6 bundle was increased in patients with severe sepsis in the absence of shock, in patients with serum lactate <4.0 mmol/L, and in patients with hypotension at the time of enrollment, regardless of the type of admission (from EDs or MWs). Subsequently, in an observational analysis, we also investigated the relation between bundle compliance and hospital mortality by logistic regression. In the after-QIP cohort, we observed a lower in-hospital mortality than that observed in the before-QIP cohort. This finding was reported in subgroups where a higher adherence to the S6 bundle in the after-QIP period was found. After adjustment for confounders, the QIP appeared to be independently associated with a significant improvement in hospital mortality. Among the single S6 procedures applied within the first hour of sepsis diagnosis, compliance with blood culture and antibiotic therapy appeared significantly associated with reduced in-hospital mortality.ConclusionA multi-faceted QIP aimed at promoting an early simplified bundle of care for the management of septic patients out of the ICU was associated with improved compliance with sepsis bundles and lower in-hospital mortality.https://www.frontiersin.org/articles/10.3389/fmed.2023.1215341/fullquality improvement programSepsismedical wardemergency departmentmortality |
| spellingShingle | Gianpaola Monti Emanuele Rezoagli Emanuele Rezoagli Angelo Calini Alice Nova Silvia Marchesi Giovanni Nattino Greta Carrara Sergio Morra Francesca Cortellaro Monica Savioli Federico Capra Marzani Moreno Tresoldi Paolo Villa Stefano Greco Paolo Bonfanti Maria Grazia Spitoni Sergio Vesconi Pietro Caironi Roberto Fumagalli Roberto Fumagalli “Lotta alla Sepsi” Team Study Group M. Aceti M. Alborghetti E. Beck W. Bonalume M. Bornaghi S. Bosisio E. Brusa V. Canegrati R. Capra A. Cecchin S. Ciccone M. De Lucia G. Erhan C. Fabbri L. Ferrante N. Ferrari S. Franchini G. Gallotta P. Galotti P. Gavazzi D. Grassi M. Lattuada C. Lorini L. Manin G. Marchesi F. Margarito F. Martini M. Meo G. Minoja M. Ortolan M. Padovani M. Pecorino A. Quaini S. Quarteroni D. Radrizzani M. Ranzini T. Santambrogio V. Savojardo A. Sciascera G. Serra M. Tajè F. Tengattin T. Tira B. Tonolli R. Traficante M. Tresoldi E. Varisco M. Zarienato C. Zeroli Effect of a quality improvement program on compliance to the sepsis bundle in non-ICU patients: a multicenter prospective before and after cohort study Frontiers in Medicine quality improvement program Sepsis medical ward emergency department mortality |
| title | Effect of a quality improvement program on compliance to the sepsis bundle in non-ICU patients: a multicenter prospective before and after cohort study |
| title_full | Effect of a quality improvement program on compliance to the sepsis bundle in non-ICU patients: a multicenter prospective before and after cohort study |
| title_fullStr | Effect of a quality improvement program on compliance to the sepsis bundle in non-ICU patients: a multicenter prospective before and after cohort study |
| title_full_unstemmed | Effect of a quality improvement program on compliance to the sepsis bundle in non-ICU patients: a multicenter prospective before and after cohort study |
| title_short | Effect of a quality improvement program on compliance to the sepsis bundle in non-ICU patients: a multicenter prospective before and after cohort study |
| title_sort | effect of a quality improvement program on compliance to the sepsis bundle in non icu patients a multicenter prospective before and after cohort study |
| topic | quality improvement program Sepsis medical ward emergency department mortality |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1215341/full |
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