Relative Nuclease Resistance of a DNA Aptamer Covalently Conjugated to a Target Protein
A major obstacle to the therapeutic application of an aptamer is its susceptibility to nuclease digestion. Here, we confirmed the acquisition of relative nuclease resistance of a DNA-type thrombin binding aptamer with a warhead (TBA<sub>3</sub>) by covalent binding to a target protein in...
Main Authors: | Yudai Tabuchi, Jay Yang, Masumi Taki |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-07-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/23/14/7778 |
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