The impact of home treatment and self-administration of omalizumab on chronic urticaria
Background: Patients suffering from Chronic Spontaneous Urticaria (CSU) may be recalcitrant to treatment with high dose second-generation antihistamines. These patients are, according to international guidelines, eligible to treatment with omalizumab. Treatment with omalizumab has proven to be very...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | World Allergy Organization Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1939455122001016 |
| _version_ | 1798006117708595200 |
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| author | Anne Christine Wiuff, MBBS Malthe Alexander Knudsgaard Wiis, MBBS Sofine Heilskov, MD Anne Sofie Frølunde, MD Jennifer Astrup Sørensen, MD Mette Deleuran, MD, DMSc Simon Francis Thomsen, MD, PhD, DMSc Christian Vestergaard, MD, PhD, DMSc |
| author_facet | Anne Christine Wiuff, MBBS Malthe Alexander Knudsgaard Wiis, MBBS Sofine Heilskov, MD Anne Sofie Frølunde, MD Jennifer Astrup Sørensen, MD Mette Deleuran, MD, DMSc Simon Francis Thomsen, MD, PhD, DMSc Christian Vestergaard, MD, PhD, DMSc |
| author_sort | Anne Christine Wiuff, MBBS |
| collection | DOAJ |
| description | Background: Patients suffering from Chronic Spontaneous Urticaria (CSU) may be recalcitrant to treatment with high dose second-generation antihistamines. These patients are, according to international guidelines, eligible to treatment with omalizumab. Treatment with omalizumab has proven to be very effective for this group of patients. Until 2018, when the self-administration of omalizumab was approved, patients have had to visit an outpatient clinic to receive the treatment. Methods: In this study we performed a survey among 75 CSU patients who had changed their treatment from administration at an outpatient clinic to self-administration at home. Results: None of the patients experienced decreased effect of the treatment with omalizumab, whereas 41.4% reported improved effect of the treatment during self-administration.The most common reported benefits for the patients were decreased travel time and the ability to choose dosing time at the day of treatment, whereas the most reported concern was fear of performing the injection. Conclusions: Patients are very content with self-administration of omalizumab. There has been no decreased effect of the treatment, and as discussed in this paper, there might be other societal benefits from self-administration. Thus, self-administration at home of omalizumab should be standard of care when using this treatment. |
| first_indexed | 2024-04-11T12:50:04Z |
| format | Article |
| id | doaj.art-b27f7204e6fe4bc280fcbc686aa96415 |
| institution | Directory Open Access Journal |
| issn | 1939-4551 |
| language | English |
| last_indexed | 2024-04-11T12:50:04Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Allergy Organization Journal |
| spelling | doaj.art-b27f7204e6fe4bc280fcbc686aa964152022-12-22T04:23:14ZengElsevierWorld Allergy Organization Journal1939-45512022-12-011512100725The impact of home treatment and self-administration of omalizumab on chronic urticariaAnne Christine Wiuff, MBBS0Malthe Alexander Knudsgaard Wiis, MBBS1Sofine Heilskov, MD2Anne Sofie Frølunde, MD3Jennifer Astrup Sørensen, MD4Mette Deleuran, MD, DMSc5Simon Francis Thomsen, MD, PhD, DMSc6Christian Vestergaard, MD, PhD, DMSc7Department of Dermatology, Aarhus University Hospital, Aarhus, DenmarkDepartment of Dermatology, Aarhus University Hospital, Aarhus, DenmarkDepartment of Dermatology, Aarhus University Hospital, Aarhus, DenmarkDepartment of Dermatology, Aarhus University Hospital, Aarhus, DenmarkDepartment of Dermatology, Bispebjerg Hospital, Copenhagen, DenmarkDepartment of Dermatology, Aarhus University Hospital, Aarhus, DenmarkDepartment of Dermatology, Bispebjerg Hospital, Copenhagen, DenmarkDepartment of Dermatology, Aarhus University Hospital, Aarhus, Denmark; Corresponding author. Department of Dermatology, Aarhus University Hospital, 8200 Aarhus N, DenmarkBackground: Patients suffering from Chronic Spontaneous Urticaria (CSU) may be recalcitrant to treatment with high dose second-generation antihistamines. These patients are, according to international guidelines, eligible to treatment with omalizumab. Treatment with omalizumab has proven to be very effective for this group of patients. Until 2018, when the self-administration of omalizumab was approved, patients have had to visit an outpatient clinic to receive the treatment. Methods: In this study we performed a survey among 75 CSU patients who had changed their treatment from administration at an outpatient clinic to self-administration at home. Results: None of the patients experienced decreased effect of the treatment with omalizumab, whereas 41.4% reported improved effect of the treatment during self-administration.The most common reported benefits for the patients were decreased travel time and the ability to choose dosing time at the day of treatment, whereas the most reported concern was fear of performing the injection. Conclusions: Patients are very content with self-administration of omalizumab. There has been no decreased effect of the treatment, and as discussed in this paper, there might be other societal benefits from self-administration. Thus, self-administration at home of omalizumab should be standard of care when using this treatment.http://www.sciencedirect.com/science/article/pii/S1939455122001016Chronic spontaneous urticariaOmalizumabSelf-administrationHome-treatmentPatient satisfaction |
| spellingShingle | Anne Christine Wiuff, MBBS Malthe Alexander Knudsgaard Wiis, MBBS Sofine Heilskov, MD Anne Sofie Frølunde, MD Jennifer Astrup Sørensen, MD Mette Deleuran, MD, DMSc Simon Francis Thomsen, MD, PhD, DMSc Christian Vestergaard, MD, PhD, DMSc The impact of home treatment and self-administration of omalizumab on chronic urticaria World Allergy Organization Journal Chronic spontaneous urticaria Omalizumab Self-administration Home-treatment Patient satisfaction |
| title | The impact of home treatment and self-administration of omalizumab on chronic urticaria |
| title_full | The impact of home treatment and self-administration of omalizumab on chronic urticaria |
| title_fullStr | The impact of home treatment and self-administration of omalizumab on chronic urticaria |
| title_full_unstemmed | The impact of home treatment and self-administration of omalizumab on chronic urticaria |
| title_short | The impact of home treatment and self-administration of omalizumab on chronic urticaria |
| title_sort | impact of home treatment and self administration of omalizumab on chronic urticaria |
| topic | Chronic spontaneous urticaria Omalizumab Self-administration Home-treatment Patient satisfaction |
| url | http://www.sciencedirect.com/science/article/pii/S1939455122001016 |
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