Characterizing the spectrum of irritability in preadolescence: Dimensional and pragmatic applications
Abstract Objectives Characterize the dimensional spectrum of preadolescent (PA) irritability, a robust transdiagnostic vulnerability marker, using the youth version of the Multidimensional Assessment Profiles Temper Loss (MAPS‐TL‐Youth) scale including common and with developmentally specific items....
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-11-01
|
| Series: | International Journal of Methods in Psychiatric Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mpr.1988 |
| _version_ | 1827750647702749184 |
|---|---|
| author | Tasmia Alam Nathan Kirk Emily Hirsch Margaret Briggs‐Gowan Lauren S. Wakschlag Amy Krain Roy Jillian Lee Wiggins |
| author_facet | Tasmia Alam Nathan Kirk Emily Hirsch Margaret Briggs‐Gowan Lauren S. Wakschlag Amy Krain Roy Jillian Lee Wiggins |
| author_sort | Tasmia Alam |
| collection | DOAJ |
| description | Abstract Objectives Characterize the dimensional spectrum of preadolescent (PA) irritability, a robust transdiagnostic vulnerability marker, using the youth version of the Multidimensional Assessment Profiles Temper Loss (MAPS‐TL‐Youth) scale including common and with developmentally specific items. Based on this, derive and validate a clinically optimized irritability screener to flag psychopathology risk in preadolescents. Methods The normal:abnormal irritability spectrum was modeled using MAPS‐TL‐Youth data from the Multidimensional Assessment of Preschoolers Study (MAPS) Study PA wave (n = 340) via item response theory. Both cross‐cutting core items from the MAPS scales and developmentally specific items were used to generate this dimension. Stepwise logistic regression was then used to optimize MAPS‐TL‐Youth irritability items in relation to Kiddie Schedule of Affective Disorders and Schizophrenia impairment to generate a clinically optimized irritability screener. Receiver operator characteristic analysis identified the irritability threshold for the screener. For the first time, youth self‐report of their own irritability on the MAPS‐TL was also modeled via the MAPS‐TL‐Youth‐Self‐Report (MAPS‐TL‐Youth‐SR). Results Irritability was unidimensional and ranged from mild and common to severe and rare behaviors. Developmentally specific items allowed detection of more severe irritability. Items for the screener were identified in relation to concurrent impairment. These included low frustration tolerance and pathognomonic severe behaviors. The clinically optimized screener demonstrated very good sensitively (87%) and specificity (81%) in regard to concurrent irritability‐related DSM disorders. Modeling of the MAPS‐TL‐Youth‐SR yielded similar results. Conclusion Characterizing the normal: abnormal spectrum of irritability in preadolescence advances application of Research Domain Criteria methods to this developmental period. This foundational work yielded two developmentally specified tools for irritability characterization in preadolescence: a nuanced dimensional scale to precisely characterize the full normal‐abnormal irritability spectrum, and a pragmatic, clinically optimized screener suitable for real world use. Future application in mechanistic and clinical studies will be important for establishing validity and incremental utility. |
| first_indexed | 2024-03-11T06:45:58Z |
| format | Article |
| id | doaj.art-b27fc2350f8e4c60bdb2a1d0a800c815 |
| institution | Directory Open Access Journal |
| issn | 1049-8931 1557-0657 |
| language | English |
| last_indexed | 2024-03-11T06:45:58Z |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Methods in Psychiatric Research |
| spelling | doaj.art-b27fc2350f8e4c60bdb2a1d0a800c8152023-11-17T10:19:55ZengWileyInternational Journal of Methods in Psychiatric Research1049-89311557-06572023-11-0132S1n/an/a10.1002/mpr.1988Characterizing the spectrum of irritability in preadolescence: Dimensional and pragmatic applicationsTasmia Alam0Nathan Kirk1Emily Hirsch2Margaret Briggs‐Gowan3Lauren S. Wakschlag4Amy Krain Roy5Jillian Lee Wiggins6Department of Psychology San Diego State University San Diego California USADepartment of Psychology San Diego State University San Diego California USADepartment of Psychology Fordham University Bronx New York USADepartment of Psychiatry University of Connecticut Health Center Farmington Connecticut USADepartment of Medical Social Sciences Feinberg School of Medicine and Institute for Innovations in Developmental Sciences Northwestern University Chicago Illinois USADepartment of Psychology Fordham University Bronx New York USADepartment of Psychology San Diego State University San Diego California USAAbstract Objectives Characterize the dimensional spectrum of preadolescent (PA) irritability, a robust transdiagnostic vulnerability marker, using the youth version of the Multidimensional Assessment Profiles Temper Loss (MAPS‐TL‐Youth) scale including common and with developmentally specific items. Based on this, derive and validate a clinically optimized irritability screener to flag psychopathology risk in preadolescents. Methods The normal:abnormal irritability spectrum was modeled using MAPS‐TL‐Youth data from the Multidimensional Assessment of Preschoolers Study (MAPS) Study PA wave (n = 340) via item response theory. Both cross‐cutting core items from the MAPS scales and developmentally specific items were used to generate this dimension. Stepwise logistic regression was then used to optimize MAPS‐TL‐Youth irritability items in relation to Kiddie Schedule of Affective Disorders and Schizophrenia impairment to generate a clinically optimized irritability screener. Receiver operator characteristic analysis identified the irritability threshold for the screener. For the first time, youth self‐report of their own irritability on the MAPS‐TL was also modeled via the MAPS‐TL‐Youth‐Self‐Report (MAPS‐TL‐Youth‐SR). Results Irritability was unidimensional and ranged from mild and common to severe and rare behaviors. Developmentally specific items allowed detection of more severe irritability. Items for the screener were identified in relation to concurrent impairment. These included low frustration tolerance and pathognomonic severe behaviors. The clinically optimized screener demonstrated very good sensitively (87%) and specificity (81%) in regard to concurrent irritability‐related DSM disorders. Modeling of the MAPS‐TL‐Youth‐SR yielded similar results. Conclusion Characterizing the normal: abnormal spectrum of irritability in preadolescence advances application of Research Domain Criteria methods to this developmental period. This foundational work yielded two developmentally specified tools for irritability characterization in preadolescence: a nuanced dimensional scale to precisely characterize the full normal‐abnormal irritability spectrum, and a pragmatic, clinically optimized screener suitable for real world use. Future application in mechanistic and clinical studies will be important for establishing validity and incremental utility.https://doi.org/10.1002/mpr.1988adolescenceirritabilitymeasurementpsychopathologyscreening |
| spellingShingle | Tasmia Alam Nathan Kirk Emily Hirsch Margaret Briggs‐Gowan Lauren S. Wakschlag Amy Krain Roy Jillian Lee Wiggins Characterizing the spectrum of irritability in preadolescence: Dimensional and pragmatic applications International Journal of Methods in Psychiatric Research adolescence irritability measurement psychopathology screening |
| title | Characterizing the spectrum of irritability in preadolescence: Dimensional and pragmatic applications |
| title_full | Characterizing the spectrum of irritability in preadolescence: Dimensional and pragmatic applications |
| title_fullStr | Characterizing the spectrum of irritability in preadolescence: Dimensional and pragmatic applications |
| title_full_unstemmed | Characterizing the spectrum of irritability in preadolescence: Dimensional and pragmatic applications |
| title_short | Characterizing the spectrum of irritability in preadolescence: Dimensional and pragmatic applications |
| title_sort | characterizing the spectrum of irritability in preadolescence dimensional and pragmatic applications |
| topic | adolescence irritability measurement psychopathology screening |
| url | https://doi.org/10.1002/mpr.1988 |
| work_keys_str_mv | AT tasmiaalam characterizingthespectrumofirritabilityinpreadolescencedimensionalandpragmaticapplications AT nathankirk characterizingthespectrumofirritabilityinpreadolescencedimensionalandpragmaticapplications AT emilyhirsch characterizingthespectrumofirritabilityinpreadolescencedimensionalandpragmaticapplications AT margaretbriggsgowan characterizingthespectrumofirritabilityinpreadolescencedimensionalandpragmaticapplications AT laurenswakschlag characterizingthespectrumofirritabilityinpreadolescencedimensionalandpragmaticapplications AT amykrainroy characterizingthespectrumofirritabilityinpreadolescencedimensionalandpragmaticapplications AT jillianleewiggins characterizingthespectrumofirritabilityinpreadolescencedimensionalandpragmaticapplications |