The functions of polycomb group proteins in T cells
T cells are involved in many aspects of adaptive immunity, including autoimmunity, anti-tumor activity, and responses to allergenic substances and pathogens. T cells undergo comprehensive epigenome remodeling in response to signals. Polycomb group (PcG) proteins are a well-studied complex of chromat...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Cell Insight |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772892722000451 |
| _version_ | 1811334208533037056 |
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| author | Ting Li |
| author_facet | Ting Li |
| author_sort | Ting Li |
| collection | DOAJ |
| description | T cells are involved in many aspects of adaptive immunity, including autoimmunity, anti-tumor activity, and responses to allergenic substances and pathogens. T cells undergo comprehensive epigenome remodeling in response to signals. Polycomb group (PcG) proteins are a well-studied complex of chromatin regulators, conserved in animals, and function in various biological processes. PcG proteins are divided into two distinct complexes: PRC1 (Polycomb repressive complex 1) and PRC2. PcG is correlated with the regulation of T cell development, phenotypic transformation, and function. In contrast, PcG dysregulation is correlated with pathogenesis of immune-mediated diseases and compromised anti-tumor responses. This review discusses recent findings on the involvement of PcG proteins in T cell maturation, differentiation, and activation. In addition, we explore implications in the development of the immune system diseases and cancer immunity, which offers promising targets for various treatment protocols. |
| first_indexed | 2024-04-13T17:04:33Z |
| format | Article |
| id | doaj.art-b280d63fdff943e1bb18efcfad06c57f |
| institution | Directory Open Access Journal |
| issn | 2772-8927 |
| language | English |
| last_indexed | 2024-04-13T17:04:33Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Insight |
| spelling | doaj.art-b280d63fdff943e1bb18efcfad06c57f2022-12-22T02:38:31ZengElsevierCell Insight2772-89272022-10-0115100048The functions of polycomb group proteins in T cellsTing Li0Department of Cell Biology, School of Basic Medical Sciences, Tianjin Medical University, 22 Qixiangtai Road, Tianjin, 300070, ChinaT cells are involved in many aspects of adaptive immunity, including autoimmunity, anti-tumor activity, and responses to allergenic substances and pathogens. T cells undergo comprehensive epigenome remodeling in response to signals. Polycomb group (PcG) proteins are a well-studied complex of chromatin regulators, conserved in animals, and function in various biological processes. PcG proteins are divided into two distinct complexes: PRC1 (Polycomb repressive complex 1) and PRC2. PcG is correlated with the regulation of T cell development, phenotypic transformation, and function. In contrast, PcG dysregulation is correlated with pathogenesis of immune-mediated diseases and compromised anti-tumor responses. This review discusses recent findings on the involvement of PcG proteins in T cell maturation, differentiation, and activation. In addition, we explore implications in the development of the immune system diseases and cancer immunity, which offers promising targets for various treatment protocols.http://www.sciencedirect.com/science/article/pii/S2772892722000451Polycomb groupT cellEpigenetics |
| spellingShingle | Ting Li The functions of polycomb group proteins in T cells Cell Insight Polycomb group T cell Epigenetics |
| title | The functions of polycomb group proteins in T cells |
| title_full | The functions of polycomb group proteins in T cells |
| title_fullStr | The functions of polycomb group proteins in T cells |
| title_full_unstemmed | The functions of polycomb group proteins in T cells |
| title_short | The functions of polycomb group proteins in T cells |
| title_sort | functions of polycomb group proteins in t cells |
| topic | Polycomb group T cell Epigenetics |
| url | http://www.sciencedirect.com/science/article/pii/S2772892722000451 |
| work_keys_str_mv | AT tingli thefunctionsofpolycombgroupproteinsintcells AT tingli functionsofpolycombgroupproteinsintcells |