High Expression of CUL9 Is Prognostic and Predictive for Adjuvant Chemotherapy in High-Risk Stage II and Stage III Colon Cancer
We evaluated the clinical implications of CUL9 expression on the prognosis and the predictive value for adjuvant chemotherapy in colon cancer. A total of 1078 consecutive patients treated with radical resection from 2008 to 2012 were included. Formalin-fixed, paraffin-embedded specimens were used as...
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MDPI AG
2022-08-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/16/3843 |
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| author | Peng Zheng Yang Lv Yihao Mao Feifan Shen Zhiyuan Zhang Jiang Chang Shanchao Yu Meiling Ji Qingyang Feng Jianmin Xu |
| author_facet | Peng Zheng Yang Lv Yihao Mao Feifan Shen Zhiyuan Zhang Jiang Chang Shanchao Yu Meiling Ji Qingyang Feng Jianmin Xu |
| author_sort | Peng Zheng |
| collection | DOAJ |
| description | We evaluated the clinical implications of CUL9 expression on the prognosis and the predictive value for adjuvant chemotherapy in colon cancer. A total of 1078 consecutive patients treated with radical resection from 2008 to 2012 were included. Formalin-fixed, paraffin-embedded specimens were used as immunohistochemistry (IHC) for CUL9. For all patients, high expression of CUL9 was identified as an independent prognostic factor for overall survival (HR = 1.613, 95% CI 1.305–1.993, <i>p</i> < 0.001) and disease-free survival (HR = 1.570, 95% CI 1.159–2.128, <i>p</i> = 0.004). The prognostic value of high CUL9 expression was confirmed in an independent validation cohort from the GEO database. The efficacy of adjuvant chemotherapy was analyzed among patients with high-risk stage II and stage III disease. Those with high CUL9 expression from the full dose group had better disease-free survival (HR = 0.477, 95% CI 0.276–0.825, <i>p</i> = 0.006) than those from the reduced dose group. The interaction test between CUL9 expression and the treatment reached significance and was not confounded by T stage, N stage and histopathological grade. In general, high expression of CUL9 was an independent prognostic factor in patients with colon cancer. In those with high-risk stage II and stage III disease, high expression of CUL9 was associated with the benefit from standard 6-months adjuvant chemotherapy regimens. |
| first_indexed | 2024-03-09T13:43:32Z |
| format | Article |
| id | doaj.art-b2817d44986144c9a8529495f3d7d562 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T13:43:32Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-b2817d44986144c9a8529495f3d7d5622023-11-30T21:03:19ZengMDPI AGCancers2072-66942022-08-011416384310.3390/cancers14163843High Expression of CUL9 Is Prognostic and Predictive for Adjuvant Chemotherapy in High-Risk Stage II and Stage III Colon CancerPeng Zheng0Yang Lv1Yihao Mao2Feifan Shen3Zhiyuan Zhang4Jiang Chang5Shanchao Yu6Meiling Ji7Qingyang Feng8Jianmin Xu9General Surgery Department, Zhongshan Hospital, Fudan University, 180 Fenglin Rd., Shanghai 200032, ChinaGeneral Surgery Department, Zhongshan Hospital, Fudan University, 180 Fenglin Rd., Shanghai 200032, ChinaGeneral Surgery Department, Zhongshan Hospital, Fudan University, 180 Fenglin Rd., Shanghai 200032, ChinaShanghai Engineering Research Center of Colorectal Cancer Minimally Invasive, Shanghai 200032, ChinaGeneral Surgery Department, Zhongshan Hospital, Fudan University, 180 Fenglin Rd., Shanghai 200032, ChinaGeneral Surgery Department, Zhongshan Hospital, Fudan University, 180 Fenglin Rd., Shanghai 200032, ChinaShanghai Engineering Research Center of Colorectal Cancer Minimally Invasive, Shanghai 200032, ChinaGeneral Surgery Department, Zhongshan Hospital, Fudan University, 180 Fenglin Rd., Shanghai 200032, ChinaGeneral Surgery Department, Zhongshan Hospital, Fudan University, 180 Fenglin Rd., Shanghai 200032, ChinaGeneral Surgery Department, Zhongshan Hospital, Fudan University, 180 Fenglin Rd., Shanghai 200032, ChinaWe evaluated the clinical implications of CUL9 expression on the prognosis and the predictive value for adjuvant chemotherapy in colon cancer. A total of 1078 consecutive patients treated with radical resection from 2008 to 2012 were included. Formalin-fixed, paraffin-embedded specimens were used as immunohistochemistry (IHC) for CUL9. For all patients, high expression of CUL9 was identified as an independent prognostic factor for overall survival (HR = 1.613, 95% CI 1.305–1.993, <i>p</i> < 0.001) and disease-free survival (HR = 1.570, 95% CI 1.159–2.128, <i>p</i> = 0.004). The prognostic value of high CUL9 expression was confirmed in an independent validation cohort from the GEO database. The efficacy of adjuvant chemotherapy was analyzed among patients with high-risk stage II and stage III disease. Those with high CUL9 expression from the full dose group had better disease-free survival (HR = 0.477, 95% CI 0.276–0.825, <i>p</i> = 0.006) than those from the reduced dose group. The interaction test between CUL9 expression and the treatment reached significance and was not confounded by T stage, N stage and histopathological grade. In general, high expression of CUL9 was an independent prognostic factor in patients with colon cancer. In those with high-risk stage II and stage III disease, high expression of CUL9 was associated with the benefit from standard 6-months adjuvant chemotherapy regimens.https://www.mdpi.com/2072-6694/14/16/3843CUL9immunohistochemistrycolorectal canceradjuvant chemotherapy |
| spellingShingle | Peng Zheng Yang Lv Yihao Mao Feifan Shen Zhiyuan Zhang Jiang Chang Shanchao Yu Meiling Ji Qingyang Feng Jianmin Xu High Expression of CUL9 Is Prognostic and Predictive for Adjuvant Chemotherapy in High-Risk Stage II and Stage III Colon Cancer Cancers CUL9 immunohistochemistry colorectal cancer adjuvant chemotherapy |
| title | High Expression of CUL9 Is Prognostic and Predictive for Adjuvant Chemotherapy in High-Risk Stage II and Stage III Colon Cancer |
| title_full | High Expression of CUL9 Is Prognostic and Predictive for Adjuvant Chemotherapy in High-Risk Stage II and Stage III Colon Cancer |
| title_fullStr | High Expression of CUL9 Is Prognostic and Predictive for Adjuvant Chemotherapy in High-Risk Stage II and Stage III Colon Cancer |
| title_full_unstemmed | High Expression of CUL9 Is Prognostic and Predictive for Adjuvant Chemotherapy in High-Risk Stage II and Stage III Colon Cancer |
| title_short | High Expression of CUL9 Is Prognostic and Predictive for Adjuvant Chemotherapy in High-Risk Stage II and Stage III Colon Cancer |
| title_sort | high expression of cul9 is prognostic and predictive for adjuvant chemotherapy in high risk stage ii and stage iii colon cancer |
| topic | CUL9 immunohistochemistry colorectal cancer adjuvant chemotherapy |
| url | https://www.mdpi.com/2072-6694/14/16/3843 |
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