The pattern and spread of invasion can predict late cervical lymph node metastasis in early tongue squamous cell carcinoma
Abstract To determine the predictive indexes of late cervical lymph node metastasis in early tongue squamous cell carcinoma (TSCC). We retrospectively analyzed the cases of 25 patients with stage I/II TSCC who had undergone surgical treatment without elective neck dissection. We evaluated the relati...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-08-01
|
| Series: | Diagnostic Pathology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13000-023-01371-3 |
| _version_ | 1797454104696455168 |
|---|---|
| author | Koroku Kato Hiroki Miyazawa Hisano Kobayashi Yoshiaki Kishikawa Hayato Funaki Natsuyo Noguchi Kazuhiro Ooi Shuichi Kawashiri |
| author_facet | Koroku Kato Hiroki Miyazawa Hisano Kobayashi Yoshiaki Kishikawa Hayato Funaki Natsuyo Noguchi Kazuhiro Ooi Shuichi Kawashiri |
| author_sort | Koroku Kato |
| collection | DOAJ |
| description | Abstract To determine the predictive indexes of late cervical lymph node metastasis in early tongue squamous cell carcinoma (TSCC). We retrospectively analyzed the cases of 25 patients with stage I/II TSCC who had undergone surgical treatment without elective neck dissection. We evaluated the relationships between clinicopathologic factors and the occurrence of late cervical lymph node metastasis. Of the 25 cases, metastasis to the cervical lymph nodes was observed in nine cases (36.0%). The clinicopathological factors associated with late cervical lymph node metastasis were the mode of invasion (MOI, p = 0.032), depth of invasion (DOI, p = 0.004), and perineural invasion (PNI, p = 0.040). A multivariate analysis revealed that only the DOI was an independent predictor of late cervical lymph node metastasis. The combination of the DOI and MOI or the PNI and MOI was significantly correlated with late cervical lymph node metastasis (p = 0.004 and p = 0.012, respectively). Our findings suggest that combinations of the MOI, DOI, and PNI could be used as an index for predicting late cervical lymph node metastasis in early TSCC. |
| first_indexed | 2024-03-09T15:32:25Z |
| format | Article |
| id | doaj.art-b281e983c68648c5a0637c092e36d90e |
| institution | Directory Open Access Journal |
| issn | 1746-1596 |
| language | English |
| last_indexed | 2024-03-09T15:32:25Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Diagnostic Pathology |
| spelling | doaj.art-b281e983c68648c5a0637c092e36d90e2023-11-26T12:10:51ZengBMCDiagnostic Pathology1746-15962023-08-011811610.1186/s13000-023-01371-3The pattern and spread of invasion can predict late cervical lymph node metastasis in early tongue squamous cell carcinomaKoroku Kato0Hiroki Miyazawa1Hisano Kobayashi2Yoshiaki Kishikawa3Hayato Funaki4Natsuyo Noguchi5Kazuhiro Ooi6Shuichi Kawashiri7Department of Oral and Maxillofacial Surgery, Kanazawa University Graduate School of Medical ScienceDepartment of Oral and Maxillofacial Surgery, Kanazawa University Graduate School of Medical ScienceDepartment of Oral and Maxillofacial Surgery, Kanazawa University Graduate School of Medical ScienceDepartment of Oral and Maxillofacial Surgery, Kanazawa University Graduate School of Medical ScienceDepartment of Oral and Maxillofacial Surgery, Kanazawa University Graduate School of Medical ScienceDepartment of Oral and Maxillofacial Surgery, Kanazawa University Graduate School of Medical ScienceDepartment of Oral and Maxillofacial Surgery, Kanazawa University Graduate School of Medical ScienceDepartment of Oral and Maxillofacial Surgery, Kanazawa University Graduate School of Medical ScienceAbstract To determine the predictive indexes of late cervical lymph node metastasis in early tongue squamous cell carcinoma (TSCC). We retrospectively analyzed the cases of 25 patients with stage I/II TSCC who had undergone surgical treatment without elective neck dissection. We evaluated the relationships between clinicopathologic factors and the occurrence of late cervical lymph node metastasis. Of the 25 cases, metastasis to the cervical lymph nodes was observed in nine cases (36.0%). The clinicopathological factors associated with late cervical lymph node metastasis were the mode of invasion (MOI, p = 0.032), depth of invasion (DOI, p = 0.004), and perineural invasion (PNI, p = 0.040). A multivariate analysis revealed that only the DOI was an independent predictor of late cervical lymph node metastasis. The combination of the DOI and MOI or the PNI and MOI was significantly correlated with late cervical lymph node metastasis (p = 0.004 and p = 0.012, respectively). Our findings suggest that combinations of the MOI, DOI, and PNI could be used as an index for predicting late cervical lymph node metastasis in early TSCC.https://doi.org/10.1186/s13000-023-01371-3Tongue squamous cell carcinomaLate cervical lymph node metastasisMode of invasionDepth of invasionPerineural invasion |
| spellingShingle | Koroku Kato Hiroki Miyazawa Hisano Kobayashi Yoshiaki Kishikawa Hayato Funaki Natsuyo Noguchi Kazuhiro Ooi Shuichi Kawashiri The pattern and spread of invasion can predict late cervical lymph node metastasis in early tongue squamous cell carcinoma Diagnostic Pathology Tongue squamous cell carcinoma Late cervical lymph node metastasis Mode of invasion Depth of invasion Perineural invasion |
| title | The pattern and spread of invasion can predict late cervical lymph node metastasis in early tongue squamous cell carcinoma |
| title_full | The pattern and spread of invasion can predict late cervical lymph node metastasis in early tongue squamous cell carcinoma |
| title_fullStr | The pattern and spread of invasion can predict late cervical lymph node metastasis in early tongue squamous cell carcinoma |
| title_full_unstemmed | The pattern and spread of invasion can predict late cervical lymph node metastasis in early tongue squamous cell carcinoma |
| title_short | The pattern and spread of invasion can predict late cervical lymph node metastasis in early tongue squamous cell carcinoma |
| title_sort | pattern and spread of invasion can predict late cervical lymph node metastasis in early tongue squamous cell carcinoma |
| topic | Tongue squamous cell carcinoma Late cervical lymph node metastasis Mode of invasion Depth of invasion Perineural invasion |
| url | https://doi.org/10.1186/s13000-023-01371-3 |
| work_keys_str_mv | AT korokukato thepatternandspreadofinvasioncanpredictlatecervicallymphnodemetastasisinearlytonguesquamouscellcarcinoma AT hirokimiyazawa thepatternandspreadofinvasioncanpredictlatecervicallymphnodemetastasisinearlytonguesquamouscellcarcinoma AT hisanokobayashi thepatternandspreadofinvasioncanpredictlatecervicallymphnodemetastasisinearlytonguesquamouscellcarcinoma AT yoshiakikishikawa thepatternandspreadofinvasioncanpredictlatecervicallymphnodemetastasisinearlytonguesquamouscellcarcinoma AT hayatofunaki thepatternandspreadofinvasioncanpredictlatecervicallymphnodemetastasisinearlytonguesquamouscellcarcinoma AT natsuyonoguchi thepatternandspreadofinvasioncanpredictlatecervicallymphnodemetastasisinearlytonguesquamouscellcarcinoma AT kazuhiroooi thepatternandspreadofinvasioncanpredictlatecervicallymphnodemetastasisinearlytonguesquamouscellcarcinoma AT shuichikawashiri thepatternandspreadofinvasioncanpredictlatecervicallymphnodemetastasisinearlytonguesquamouscellcarcinoma AT korokukato patternandspreadofinvasioncanpredictlatecervicallymphnodemetastasisinearlytonguesquamouscellcarcinoma AT hirokimiyazawa patternandspreadofinvasioncanpredictlatecervicallymphnodemetastasisinearlytonguesquamouscellcarcinoma AT hisanokobayashi patternandspreadofinvasioncanpredictlatecervicallymphnodemetastasisinearlytonguesquamouscellcarcinoma AT yoshiakikishikawa patternandspreadofinvasioncanpredictlatecervicallymphnodemetastasisinearlytonguesquamouscellcarcinoma AT hayatofunaki patternandspreadofinvasioncanpredictlatecervicallymphnodemetastasisinearlytonguesquamouscellcarcinoma AT natsuyonoguchi patternandspreadofinvasioncanpredictlatecervicallymphnodemetastasisinearlytonguesquamouscellcarcinoma AT kazuhiroooi patternandspreadofinvasioncanpredictlatecervicallymphnodemetastasisinearlytonguesquamouscellcarcinoma AT shuichikawashiri patternandspreadofinvasioncanpredictlatecervicallymphnodemetastasisinearlytonguesquamouscellcarcinoma |