Sertindole in the Management of Schizophrenia
Nowadays, new schizophrenia treatments are more ambitious than ever, aiming not only to improve psychotic symptoms, but also quality of life and social reinsertion. Our objective is to briefly but critically review the diagnosis of schizophrenia, the atypical antipsychotics sertindole's pharmac...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2011-01-01
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| Series: | Journal of Central Nervous System Disease |
| Online Access: | https://doi.org/10.4137/JCNSD.S5729 |
| _version_ | 1818033903244410880 |
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| author | Mario F. Juruena Eduardo Ponde00C9; De Sena Irismar Reis De Oliveira |
| author_facet | Mario F. Juruena Eduardo Ponde00C9; De Sena Irismar Reis De Oliveira |
| author_sort | Mario F. Juruena |
| collection | DOAJ |
| description | Nowadays, new schizophrenia treatments are more ambitious than ever, aiming not only to improve psychotic symptoms, but also quality of life and social reinsertion. Our objective is to briefly but critically review the diagnosis of schizophrenia, the atypical antipsychotics sertindole's pharmacology, safety and status, and mainly evaluate the effects of sertindole compared with other second generation antipsychotics for people with schizophrenia and schizophrenia-like psychosis. In vitro studies showed that sertindole exerts a potent antagonism at serotonin 5-HT 2A , 5-HT 2C , dopamine D 2 , and α l adrenergic receptors. Sertindole offers an alternative treatment option for refractory patients given its good EPS profile, favorable metabolic profile, and comparable efficacy to risperidone. Due to cardiovascular safety concerns, sertindole is available as a second-line choice for patients intolerant to other antipsychotic agents. Further clinical studies, mainly comparisons with other second-generation antipsychotic agents, are needed to define the role of sertindole in the treatment of schizophrenia. |
| first_indexed | 2024-12-10T06:30:39Z |
| format | Article |
| id | doaj.art-b28290417d0c47b7b0bdb6db3f9646c6 |
| institution | Directory Open Access Journal |
| issn | 1179-5735 |
| language | English |
| last_indexed | 2024-12-10T06:30:39Z |
| publishDate | 2011-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Central Nervous System Disease |
| spelling | doaj.art-b28290417d0c47b7b0bdb6db3f9646c62022-12-22T01:59:04ZengSAGE PublishingJournal of Central Nervous System Disease1179-57352011-01-01310.4137/JCNSD.S5729Sertindole in the Management of SchizophreniaMario F. Juruena0Eduardo Ponde00C9; De Sena1Irismar Reis De Oliveira2 Stress and Affective Disorders Programme, Department of Neuroscience and Behaviour, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil. Department of Pharmacology, Institute of Health Sciences, Federal University of Bahia, Salvador, Brazil. Department of Neurosciences and Mental Health, School of Medicine, Federal University of Bahia, Salvador, Brazil.Nowadays, new schizophrenia treatments are more ambitious than ever, aiming not only to improve psychotic symptoms, but also quality of life and social reinsertion. Our objective is to briefly but critically review the diagnosis of schizophrenia, the atypical antipsychotics sertindole's pharmacology, safety and status, and mainly evaluate the effects of sertindole compared with other second generation antipsychotics for people with schizophrenia and schizophrenia-like psychosis. In vitro studies showed that sertindole exerts a potent antagonism at serotonin 5-HT 2A , 5-HT 2C , dopamine D 2 , and α l adrenergic receptors. Sertindole offers an alternative treatment option for refractory patients given its good EPS profile, favorable metabolic profile, and comparable efficacy to risperidone. Due to cardiovascular safety concerns, sertindole is available as a second-line choice for patients intolerant to other antipsychotic agents. Further clinical studies, mainly comparisons with other second-generation antipsychotic agents, are needed to define the role of sertindole in the treatment of schizophrenia.https://doi.org/10.4137/JCNSD.S5729 |
| spellingShingle | Mario F. Juruena Eduardo Ponde00C9; De Sena Irismar Reis De Oliveira Sertindole in the Management of Schizophrenia Journal of Central Nervous System Disease |
| title | Sertindole in the Management of Schizophrenia |
| title_full | Sertindole in the Management of Schizophrenia |
| title_fullStr | Sertindole in the Management of Schizophrenia |
| title_full_unstemmed | Sertindole in the Management of Schizophrenia |
| title_short | Sertindole in the Management of Schizophrenia |
| title_sort | sertindole in the management of schizophrenia |
| url | https://doi.org/10.4137/JCNSD.S5729 |
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