PTTG and p21 as prognostic biomarker in radiotherapy for non-functional pituitary adenomas
Objective To evaluate the predictive value of pituitary tumor transforming gene (PTTG) and cycle-dependent kinase inhibitor 1A (p21) in the prognosis of pituitary adenomas underwent radiotherapy. Methods A total of 89 postoperative patients with non-functional pituitary adenomas(NFPAs) treate...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2021-09-01
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| Series: | Jichu yixue yu linchuang |
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| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a201284.pdf |
| _version_ | 1827390542372143104 |
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| author | LI Yang-fang, HU Hui-min |
| author_facet | LI Yang-fang, HU Hui-min |
| author_sort | LI Yang-fang, HU Hui-min |
| collection | DOAJ |
| description | Objective To evaluate the predictive value of pituitary tumor transforming gene (PTTG) and cycle-dependent kinase inhibitor 1A (p21) in the prognosis of pituitary adenomas underwent radiotherapy. Methods A total of 89 postoperative patients with non-functional pituitary adenomas(NFPAs) treated by gamma knife radiosurgery (GKRS) from 2003 to 2013 were collected.The cases were divided into research and validation cohorts based on the radiosurgery operation time. According to the follow-up MRI, a decrease of tumor more than 20% was defined as radiosensitive; Expression of sixteen protein markers in pituitary adenomas was determined using a tissue microarray. Results Univariate analysis revealed that nucleus positive PTTG(HR:1.355; P＜0.05 or HR:1.637; P＜0.01) and cytoplasm high expression of p21(HR:1.174; P＜0.01 or HR:1.378; P＜0.01) were significantly correlated with radiation resistance in both research and validation group. In the research group, Kaplan Meyer (KM) curve analysis showed patients with nucleus negative PTTG (P＜0.01) and cytoplasm low expression of p21(P＜0.01) had a higher radiosensitivity, the same results were obtained in the validation group(PTTG,P＜0.05; p21,P＜0.01). Conclusions Patients with nucleus positive PTTG and cytoplasm high expression of p21 tend to be resistant to radiotherapy in pituitary adenomas; PTTG and p21 are prognostic protein markers associated with radiation resistance. |
| first_indexed | 2024-03-08T16:54:10Z |
| format | Article |
| id | doaj.art-b284f80cf8304a33bef4fa0b9e2a3d89 |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-08T16:54:10Z |
| publishDate | 2021-09-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-b284f80cf8304a33bef4fa0b9e2a3d892024-01-05T03:07:03ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252021-09-0141912531259PTTG and p21 as prognostic biomarker in radiotherapy for non-functional pituitary adenomasLI Yang-fang, HU Hui-min01. Beijing Neurosurgical Institute, Beijing 100070;;2. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, ChinaObjective To evaluate the predictive value of pituitary tumor transforming gene (PTTG) and cycle-dependent kinase inhibitor 1A (p21) in the prognosis of pituitary adenomas underwent radiotherapy. Methods A total of 89 postoperative patients with non-functional pituitary adenomas(NFPAs) treated by gamma knife radiosurgery (GKRS) from 2003 to 2013 were collected.The cases were divided into research and validation cohorts based on the radiosurgery operation time. According to the follow-up MRI, a decrease of tumor more than 20% was defined as radiosensitive; Expression of sixteen protein markers in pituitary adenomas was determined using a tissue microarray. Results Univariate analysis revealed that nucleus positive PTTG(HR:1.355; P＜0.05 or HR:1.637; P＜0.01) and cytoplasm high expression of p21(HR:1.174; P＜0.01 or HR:1.378; P＜0.01) were significantly correlated with radiation resistance in both research and validation group. In the research group, Kaplan Meyer (KM) curve analysis showed patients with nucleus negative PTTG (P＜0.01) and cytoplasm low expression of p21(P＜0.01) had a higher radiosensitivity, the same results were obtained in the validation group(PTTG,P＜0.05; p21,P＜0.01). Conclusions Patients with nucleus positive PTTG and cytoplasm high expression of p21 tend to be resistant to radiotherapy in pituitary adenomas; PTTG and p21 are prognostic protein markers associated with radiation resistance.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a201284.pdfpituitary tumor transforming gene(pttg)|cycle-dependent kinase inhibitor 1a(p21)|tissue microarray| radiation resistance |
| spellingShingle | LI Yang-fang, HU Hui-min PTTG and p21 as prognostic biomarker in radiotherapy for non-functional pituitary adenomas Jichu yixue yu linchuang pituitary tumor transforming gene(pttg)|cycle-dependent kinase inhibitor 1a(p21)|tissue microarray| radiation resistance |
| title | PTTG and p21 as prognostic biomarker in radiotherapy for non-functional pituitary adenomas |
| title_full | PTTG and p21 as prognostic biomarker in radiotherapy for non-functional pituitary adenomas |
| title_fullStr | PTTG and p21 as prognostic biomarker in radiotherapy for non-functional pituitary adenomas |
| title_full_unstemmed | PTTG and p21 as prognostic biomarker in radiotherapy for non-functional pituitary adenomas |
| title_short | PTTG and p21 as prognostic biomarker in radiotherapy for non-functional pituitary adenomas |
| title_sort | pttg and p21 as prognostic biomarker in radiotherapy for non functional pituitary adenomas |
| topic | pituitary tumor transforming gene(pttg)|cycle-dependent kinase inhibitor 1a(p21)|tissue microarray| radiation resistance |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a201284.pdf |
| work_keys_str_mv | AT liyangfanghuhuimin pttgandp21asprognosticbiomarkerinradiotherapyfornonfunctionalpituitaryadenomas |