Knocking down GALNT6 promotes pyroptosis of pancreatic ductal adenocarcinoma cells through NF-κB/NLRP3/GSDMD and GSDME signaling pathway

Knocking down GALNT6 promotes pyroptosis of pancreatic ductal adenocarcinoma cells through NF-κB/NLRP3/GSDMD and GSDME signaling pathway

BackgroundPancreatic ductal adenocarcinoma (PDAC), the most prevalent type of pancreatic cancer, is a highly lethal malignancy with poor prognosis. Polypeptide N-acetylgalactosaminyltransferase-6 (GALNT6) is frequently overexpressed in PDAC. However, the role of GALNT6 in the PDAC remains unclear.Me...

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Bibliographic Details
Main Authors: Mengyang Ding, Jingyu Liu, Honghui Lv, Yanlin Zhu, Yumiao Chen, Hui Peng, Sairong Fan, Xiaoming Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Oncology
Subjects:
pancreatic ductal adenocarcinoma
GALNT6
pyroptosis
NF-κB
GSDME
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1097772/full

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