The role of brain derived neurotrophic factor in central nervous system
Brain derived neurotrophic factor (BDNF) has multiple biological functions which are mediated by the activation of two receptors, tropomyosin receptor kinase B (TrkB) receptor and the p75 neurotrophin receptor, involving in physiological and pathological processes throughout life. The diverse presen...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.986443/full |
| _version_ | 1798002098012422144 |
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| author | Yiyi Li Yiyi Li Fang Li Fang Li Dongdong Qin Dongdong Qin Hongyu Chen Hongyu Chen Jianhao Wang Jianhao Wang Jiabei Wang Jiabei Wang Shafei Song Shafei Song Chao Wang Chao Wang Yamei Wang Yamei Wang Songyan Liu Songyan Liu Dandan Gao Dandan Gao Zhi-Hao Wang Zhi-Hao Wang |
| author_facet | Yiyi Li Yiyi Li Fang Li Fang Li Dongdong Qin Dongdong Qin Hongyu Chen Hongyu Chen Jianhao Wang Jianhao Wang Jiabei Wang Jiabei Wang Shafei Song Shafei Song Chao Wang Chao Wang Yamei Wang Yamei Wang Songyan Liu Songyan Liu Dandan Gao Dandan Gao Zhi-Hao Wang Zhi-Hao Wang |
| author_sort | Yiyi Li |
| collection | DOAJ |
| description | Brain derived neurotrophic factor (BDNF) has multiple biological functions which are mediated by the activation of two receptors, tropomyosin receptor kinase B (TrkB) receptor and the p75 neurotrophin receptor, involving in physiological and pathological processes throughout life. The diverse presence and activity of BDNF indicate its potential role in the pathogenesis, progression and treatment of both neurological and psychiatric disorders. This review is to provide a comprehensive assessment of the current knowledge and future directions in BDNF-associated research in the central nervous system (CNS), with an emphasis on the physiological and pathological functions of BDNF as well as its potential treatment effects in CNS diseases, including depression, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, multiple sclerosis, and cerebral ischemic stroke. |
| first_indexed | 2024-04-11T11:46:55Z |
| format | Article |
| id | doaj.art-b285ff62b0a74adcb6a51163437bce22 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-11T11:46:55Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-b285ff62b0a74adcb6a51163437bce222022-12-22T04:25:32ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-09-011410.3389/fnagi.2022.986443986443The role of brain derived neurotrophic factor in central nervous systemYiyi Li0Yiyi Li1Fang Li2Fang Li3Dongdong Qin4Dongdong Qin5Hongyu Chen6Hongyu Chen7Jianhao Wang8Jianhao Wang9Jiabei Wang10Jiabei Wang11Shafei Song12Shafei Song13Chao Wang14Chao Wang15Yamei Wang16Yamei Wang17Songyan Liu18Songyan Liu19Dandan Gao20Dandan Gao21Zhi-Hao Wang22Zhi-Hao Wang23Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, ChinaCenter for Neurodegenerative Disease Research, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan, ChinaCenter for Neurodegenerative Disease Research, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan, ChinaCenter for Neurodegenerative Disease Research, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan, ChinaCenter for Neurodegenerative Disease Research, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan, ChinaCenter for Neurodegenerative Disease Research, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan, ChinaCenter for Neurodegenerative Disease Research, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan, ChinaCenter for Neurodegenerative Disease Research, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan, ChinaCenter for Neurodegenerative Disease Research, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan, ChinaCenter for Neurodegenerative Disease Research, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan, ChinaCenter for Neurodegenerative Disease Research, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan, ChinaCenter for Neurodegenerative Disease Research, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan, ChinaCenter for Neurodegenerative Disease Research, Renmin Hospital of Wuhan University, Wuhan, ChinaBrain derived neurotrophic factor (BDNF) has multiple biological functions which are mediated by the activation of two receptors, tropomyosin receptor kinase B (TrkB) receptor and the p75 neurotrophin receptor, involving in physiological and pathological processes throughout life. The diverse presence and activity of BDNF indicate its potential role in the pathogenesis, progression and treatment of both neurological and psychiatric disorders. This review is to provide a comprehensive assessment of the current knowledge and future directions in BDNF-associated research in the central nervous system (CNS), with an emphasis on the physiological and pathological functions of BDNF as well as its potential treatment effects in CNS diseases, including depression, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, multiple sclerosis, and cerebral ischemic stroke.https://www.frontiersin.org/articles/10.3389/fnagi.2022.986443/fullbrain derived neurotrophic factorphysiologicalpathologicaltreatmentcentral nervous system |
| spellingShingle | Yiyi Li Yiyi Li Fang Li Fang Li Dongdong Qin Dongdong Qin Hongyu Chen Hongyu Chen Jianhao Wang Jianhao Wang Jiabei Wang Jiabei Wang Shafei Song Shafei Song Chao Wang Chao Wang Yamei Wang Yamei Wang Songyan Liu Songyan Liu Dandan Gao Dandan Gao Zhi-Hao Wang Zhi-Hao Wang The role of brain derived neurotrophic factor in central nervous system Frontiers in Aging Neuroscience brain derived neurotrophic factor physiological pathological treatment central nervous system |
| title | The role of brain derived neurotrophic factor in central nervous system |
| title_full | The role of brain derived neurotrophic factor in central nervous system |
| title_fullStr | The role of brain derived neurotrophic factor in central nervous system |
| title_full_unstemmed | The role of brain derived neurotrophic factor in central nervous system |
| title_short | The role of brain derived neurotrophic factor in central nervous system |
| title_sort | role of brain derived neurotrophic factor in central nervous system |
| topic | brain derived neurotrophic factor physiological pathological treatment central nervous system |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.986443/full |
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