Immunogenicity and Potential for Intraocular Inflammation of Intravitreal Anti-VEGF Drugs
Background: Concerns of intraocular inflammation associated with intravitreal administration of anti-VEGF drugs have been risen and the exact mechanism is not yet elucidated. Objective: To explore the relationship between immunogenicity and intraocular inflammation in intravitreal anti-VEGF drugs. M...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Current Therapeutic Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0011393X24000122 |
| _version_ | 1797220285717413888 |
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| author | Hyeong Min Kim, MD, MSc Se Joon Woo, MD, PhD |
| author_facet | Hyeong Min Kim, MD, MSc Se Joon Woo, MD, PhD |
| author_sort | Hyeong Min Kim, MD, MSc |
| collection | DOAJ |
| description | Background: Concerns of intraocular inflammation associated with intravitreal administration of anti-VEGF drugs have been risen and the exact mechanism is not yet elucidated. Objective: To explore the relationship between immunogenicity and intraocular inflammation in intravitreal anti-VEGF drugs. Methods: This review examines the immunogenicity of individual intravitreal anti-VEGF drugs and their potential link to intraocular inflammation. Results: We suggest that the main cause of intraocular inflammation is the presence of pre-existing and treatment-induced antidrug antibodies, along with considerations related to the molecular structure, which includes the drug's format and size. Conclusions: Researchers and clinicians involved in the advancement of new anti-VEGF drugs should take into consideration the factors related to intraocular inflammation that have been discussed. |
| first_indexed | 2024-04-24T12:47:07Z |
| format | Article |
| id | doaj.art-b2883d08985040318075574eb813b88b |
| institution | Directory Open Access Journal |
| issn | 0011-393X |
| language | English |
| last_indexed | 2024-04-24T12:47:07Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Therapeutic Research |
| spelling | doaj.art-b2883d08985040318075574eb813b88b2024-04-07T04:35:09ZengElsevierCurrent Therapeutic Research0011-393X2024-01-01100100742Immunogenicity and Potential for Intraocular Inflammation of Intravitreal Anti-VEGF DrugsHyeong Min Kim, MD, MSc0Se Joon Woo, MD, PhD1Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea; Department of Ophthalmology, Konkuk University School of Medicine, Seoul, Republic of KoreaDepartment of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea; Address correspondence to: Se Joon Woo, MD, PhD, Department of Ophthalmology, Seoul National University Bundang Hospital, 173-82 Gumi-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, Republic of Korea.Background: Concerns of intraocular inflammation associated with intravitreal administration of anti-VEGF drugs have been risen and the exact mechanism is not yet elucidated. Objective: To explore the relationship between immunogenicity and intraocular inflammation in intravitreal anti-VEGF drugs. Methods: This review examines the immunogenicity of individual intravitreal anti-VEGF drugs and their potential link to intraocular inflammation. Results: We suggest that the main cause of intraocular inflammation is the presence of pre-existing and treatment-induced antidrug antibodies, along with considerations related to the molecular structure, which includes the drug's format and size. Conclusions: Researchers and clinicians involved in the advancement of new anti-VEGF drugs should take into consideration the factors related to intraocular inflammation that have been discussed.http://www.sciencedirect.com/science/article/pii/S0011393X24000122Anti-VEGFImmunogenicityIntraocular inflammation |
| spellingShingle | Hyeong Min Kim, MD, MSc Se Joon Woo, MD, PhD Immunogenicity and Potential for Intraocular Inflammation of Intravitreal Anti-VEGF Drugs Current Therapeutic Research Anti-VEGF Immunogenicity Intraocular inflammation |
| title | Immunogenicity and Potential for Intraocular Inflammation of Intravitreal Anti-VEGF Drugs |
| title_full | Immunogenicity and Potential for Intraocular Inflammation of Intravitreal Anti-VEGF Drugs |
| title_fullStr | Immunogenicity and Potential for Intraocular Inflammation of Intravitreal Anti-VEGF Drugs |
| title_full_unstemmed | Immunogenicity and Potential for Intraocular Inflammation of Intravitreal Anti-VEGF Drugs |
| title_short | Immunogenicity and Potential for Intraocular Inflammation of Intravitreal Anti-VEGF Drugs |
| title_sort | immunogenicity and potential for intraocular inflammation of intravitreal anti vegf drugs |
| topic | Anti-VEGF Immunogenicity Intraocular inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S0011393X24000122 |
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