Developmental Changes in HCN Channel Modulation of Neocortical Layer 1 Interneurons
Layer 1 (L1) interneurons (INs) play a key role in modulating the integration of inputs to pyramidal neurons (PNs) and controlling cortical network activity. Hyperpolarization-activated, cyclic nucleotide-gated, non-specific cation (HCN) channels are known to alter the intrinsic and synaptic excitab...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-01-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fncel.2018.00020/full |
| _version_ | 1817992316243148800 |
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| author | Andrew S. Bohannon John J. Hablitz |
| author_facet | Andrew S. Bohannon John J. Hablitz |
| author_sort | Andrew S. Bohannon |
| collection | DOAJ |
| description | Layer 1 (L1) interneurons (INs) play a key role in modulating the integration of inputs to pyramidal neurons (PNs) and controlling cortical network activity. Hyperpolarization-activated, cyclic nucleotide-gated, non-specific cation (HCN) channels are known to alter the intrinsic and synaptic excitability of principal components (PCs) as well as select populations of GABAergic INs. However, the developmental profile and functional role of HCN channels in diverse L1 IN populations is not completely understood. In the present study, we used electrophysiological characterization, in conjunction with unbiased hierarchical cluster analysis, to examine developmental modulation of L1 INs by HCN channels in the rat medial agranular cortex (AGm). We identified three physiologically discrete IN populations which were classified as regular spiking (RS), burst accommodating (BA) and non-accommodating (NA). A distinct developmental pattern of excitability modulation by HCN channels was observed for each group. RS and NA cells displayed distinct morphologies with modulation of EPSPs increasing in RS cells and decreasing in NA cells across development. The results indicate a possible role of HCN channels in the formation and maintenance of cortical circuits through alteration of the excitability of distinct AGm L1 INs. |
| first_indexed | 2024-04-14T01:24:45Z |
| format | Article |
| id | doaj.art-b28d74d489a846c7b917a23f98faf0af |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-04-14T01:24:45Z |
| publishDate | 2018-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-b28d74d489a846c7b917a23f98faf0af2022-12-22T02:20:30ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022018-01-011210.3389/fncel.2018.00020295939Developmental Changes in HCN Channel Modulation of Neocortical Layer 1 InterneuronsAndrew S. Bohannon0John J. Hablitz1epartment of Neurobiology, University of Alabama at Birmingham, Birmingham, AL, United Statesepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, AL, United StatesLayer 1 (L1) interneurons (INs) play a key role in modulating the integration of inputs to pyramidal neurons (PNs) and controlling cortical network activity. Hyperpolarization-activated, cyclic nucleotide-gated, non-specific cation (HCN) channels are known to alter the intrinsic and synaptic excitability of principal components (PCs) as well as select populations of GABAergic INs. However, the developmental profile and functional role of HCN channels in diverse L1 IN populations is not completely understood. In the present study, we used electrophysiological characterization, in conjunction with unbiased hierarchical cluster analysis, to examine developmental modulation of L1 INs by HCN channels in the rat medial agranular cortex (AGm). We identified three physiologically discrete IN populations which were classified as regular spiking (RS), burst accommodating (BA) and non-accommodating (NA). A distinct developmental pattern of excitability modulation by HCN channels was observed for each group. RS and NA cells displayed distinct morphologies with modulation of EPSPs increasing in RS cells and decreasing in NA cells across development. The results indicate a possible role of HCN channels in the formation and maintenance of cortical circuits through alteration of the excitability of distinct AGm L1 INs.http://journal.frontiersin.org/article/10.3389/fncel.2018.00020/fullHCN channelsinterneuron developmentlayer 1medial agranular cortexsynaptic integration |
| spellingShingle | Andrew S. Bohannon John J. Hablitz Developmental Changes in HCN Channel Modulation of Neocortical Layer 1 Interneurons Frontiers in Cellular Neuroscience HCN channels interneuron development layer 1 medial agranular cortex synaptic integration |
| title | Developmental Changes in HCN Channel Modulation of Neocortical Layer 1 Interneurons |
| title_full | Developmental Changes in HCN Channel Modulation of Neocortical Layer 1 Interneurons |
| title_fullStr | Developmental Changes in HCN Channel Modulation of Neocortical Layer 1 Interneurons |
| title_full_unstemmed | Developmental Changes in HCN Channel Modulation of Neocortical Layer 1 Interneurons |
| title_short | Developmental Changes in HCN Channel Modulation of Neocortical Layer 1 Interneurons |
| title_sort | developmental changes in hcn channel modulation of neocortical layer 1 interneurons |
| topic | HCN channels interneuron development layer 1 medial agranular cortex synaptic integration |
| url | http://journal.frontiersin.org/article/10.3389/fncel.2018.00020/full |
| work_keys_str_mv | AT andrewsbohannon developmentalchangesinhcnchannelmodulationofneocorticallayer1interneurons AT johnjhablitz developmentalchangesinhcnchannelmodulationofneocorticallayer1interneurons |