Preconceptional, Gestational, and Lactational Exposure to an Unconventional Oil and Gas Chemical Mixture Alters Energy Expenditure in Adult Female Mice
Previous studies conducted in our laboratory have found altered adult health outcomes in animals with prenatal exposure to environmentally relevant levels of unconventional oil and gas (UOG) chemicals with endocrine-disrupting activity. This study aimed to examine potential metabolic health outcomes...
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Frontiers Media S.A.
2019-05-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2019.00323/full |
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| author | Victoria D. Balise Victoria D. Balise Jennifer N. Cornelius-Green Christopher D. Kassotis R. Scott Rector R. Scott Rector R. Scott Rector John P. Thyfault John P. Thyfault Susan C. Nagel Susan C. Nagel |
| author_facet | Victoria D. Balise Victoria D. Balise Jennifer N. Cornelius-Green Christopher D. Kassotis R. Scott Rector R. Scott Rector R. Scott Rector John P. Thyfault John P. Thyfault Susan C. Nagel Susan C. Nagel |
| author_sort | Victoria D. Balise |
| collection | DOAJ |
| description | Previous studies conducted in our laboratory have found altered adult health outcomes in animals with prenatal exposure to environmentally relevant levels of unconventional oil and gas (UOG) chemicals with endocrine-disrupting activity. This study aimed to examine potential metabolic health outcomes following a preconception, prenatal and postnatal exposure to a mixture of 23 UOG chemicals. Prior to mating and from gestation day 1 to postnatal day 21, C57BL/6J mice were developmentally exposed to a laboratory-created mixture of 23 UOG chemicals in maternal drinking water. Body composition, spontaneous activity, energy expenditure, and glucose tolerance were evaluated in 7-month-old female offspring. Neither body weight nor body composition differed in 7-month female mice. However, females exposed to 1.5 and 150 μg/kg/day UOG mix had lower total and resting energy expenditure within the dark cycle. In the light cycle, the 1,500 μg//kg/day group had lower total energy expenditure and the 1.5 μg/kg/day group had lower resting energy expenditure. Females exposed to the 150 μg/kg/day group had lower spontaneous activity in the dark cycle, and females exposed to the 1,500 μg/kg/day group had lower activity in the light cycle. This study reports for the first time that developmental exposure to a mixture of 23 UOG chemicals alters energy expenditure and spontaneous activity in adult female mice. |
| first_indexed | 2024-12-14T00:56:45Z |
| format | Article |
| id | doaj.art-b28e755a20e24746993f2e5c4301af73 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-14T00:56:45Z |
| publishDate | 2019-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-b28e755a20e24746993f2e5c4301af732022-12-21T23:23:30ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922019-05-011010.3389/fendo.2019.00323427815Preconceptional, Gestational, and Lactational Exposure to an Unconventional Oil and Gas Chemical Mixture Alters Energy Expenditure in Adult Female MiceVictoria D. Balise0Victoria D. Balise1Jennifer N. Cornelius-Green2Christopher D. Kassotis3R. Scott Rector4R. Scott Rector5R. Scott Rector6John P. Thyfault7John P. Thyfault8Susan C. Nagel9Susan C. Nagel10Department of Obstetrics, Gynecology and Women's Health, University of Missouri, Columbia, MO, United StatesDepartment of Biological Sciences, University of Missouri, Columbia, MO, United StatesDepartment of Obstetrics, Gynecology and Women's Health, University of Missouri, Columbia, MO, United StatesNicholas School of the Environment, Duke University, Durham, NC, United StatesDepartment of Nutrition and Health Exercise Physiology, University of Missouri, Columbia, MO, United StatesMedicine-Division of Gastroenterology and Hepatology, University of Missouri, Columbia, MO, United StatesResearch Service, Harry S Truman Memorial Veterans Medical Center, Columbia, MO, United StatesDepartment of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, United StatesKansas City VA Medical Center, Research Service, Kansas City, MO, United StatesDepartment of Obstetrics, Gynecology and Women's Health, University of Missouri, Columbia, MO, United StatesDepartment of Biological Sciences, University of Missouri, Columbia, MO, United StatesPrevious studies conducted in our laboratory have found altered adult health outcomes in animals with prenatal exposure to environmentally relevant levels of unconventional oil and gas (UOG) chemicals with endocrine-disrupting activity. This study aimed to examine potential metabolic health outcomes following a preconception, prenatal and postnatal exposure to a mixture of 23 UOG chemicals. Prior to mating and from gestation day 1 to postnatal day 21, C57BL/6J mice were developmentally exposed to a laboratory-created mixture of 23 UOG chemicals in maternal drinking water. Body composition, spontaneous activity, energy expenditure, and glucose tolerance were evaluated in 7-month-old female offspring. Neither body weight nor body composition differed in 7-month female mice. However, females exposed to 1.5 and 150 μg/kg/day UOG mix had lower total and resting energy expenditure within the dark cycle. In the light cycle, the 1,500 μg//kg/day group had lower total energy expenditure and the 1.5 μg/kg/day group had lower resting energy expenditure. Females exposed to the 150 μg/kg/day group had lower spontaneous activity in the dark cycle, and females exposed to the 1,500 μg/kg/day group had lower activity in the light cycle. This study reports for the first time that developmental exposure to a mixture of 23 UOG chemicals alters energy expenditure and spontaneous activity in adult female mice.https://www.frontiersin.org/article/10.3389/fendo.2019.00323/fullunconventional oil and gasenergy expenditureendocrine disrupting chemicalsdevelopmental origins of health and diseasehydraulic fracturingmetabolism |
| spellingShingle | Victoria D. Balise Victoria D. Balise Jennifer N. Cornelius-Green Christopher D. Kassotis R. Scott Rector R. Scott Rector R. Scott Rector John P. Thyfault John P. Thyfault Susan C. Nagel Susan C. Nagel Preconceptional, Gestational, and Lactational Exposure to an Unconventional Oil and Gas Chemical Mixture Alters Energy Expenditure in Adult Female Mice Frontiers in Endocrinology unconventional oil and gas energy expenditure endocrine disrupting chemicals developmental origins of health and disease hydraulic fracturing metabolism |
| title | Preconceptional, Gestational, and Lactational Exposure to an Unconventional Oil and Gas Chemical Mixture Alters Energy Expenditure in Adult Female Mice |
| title_full | Preconceptional, Gestational, and Lactational Exposure to an Unconventional Oil and Gas Chemical Mixture Alters Energy Expenditure in Adult Female Mice |
| title_fullStr | Preconceptional, Gestational, and Lactational Exposure to an Unconventional Oil and Gas Chemical Mixture Alters Energy Expenditure in Adult Female Mice |
| title_full_unstemmed | Preconceptional, Gestational, and Lactational Exposure to an Unconventional Oil and Gas Chemical Mixture Alters Energy Expenditure in Adult Female Mice |
| title_short | Preconceptional, Gestational, and Lactational Exposure to an Unconventional Oil and Gas Chemical Mixture Alters Energy Expenditure in Adult Female Mice |
| title_sort | preconceptional gestational and lactational exposure to an unconventional oil and gas chemical mixture alters energy expenditure in adult female mice |
| topic | unconventional oil and gas energy expenditure endocrine disrupting chemicals developmental origins of health and disease hydraulic fracturing metabolism |
| url | https://www.frontiersin.org/article/10.3389/fendo.2019.00323/full |
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