Unexplained Male infertility: diagnosis and Management
Unexplained male infertility is a diagnosis reserved for men in whom routine semen analyses results are within normal values and physical as well as endocrine abnormalities were ruled out. In addition to erectile problems and coital factors, immunologic causes and sperm dysfunction may contribute to...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Urologia
2012-10-01
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| Series: | International Brazilian Journal of Urology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382012000500002 |
| _version_ | 1811305036029886464 |
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| author | Alaa Hamada Sandro C. Esteves Mark Nizza Ashok Agarwal |
| author_facet | Alaa Hamada Sandro C. Esteves Mark Nizza Ashok Agarwal |
| author_sort | Alaa Hamada |
| collection | DOAJ |
| description | Unexplained male infertility is a diagnosis reserved for men in whom routine semen analyses results are within normal values and physical as well as endocrine abnormalities were ruled out. In addition to erectile problems and coital factors, immunologic causes and sperm dysfunction may contribute to such condition. New etiologies of unexplained male infertility include low level leukocytospermia and mitochondrial DNA polymerase gene polymorphism. Contemporary andrology may reveal cellular and sub-cellular sperm dysfunctions which may explain subfertility in such cases, thus aiding the clinician to direct the further work-up, diagnosis and counseling of the infertile male. The objective of this article is to highlight the concept of unexplained male infertility and focuses on the diagnosis and treatment of this condition in the era of modern andrology and assisted reproductive techniques. Extensive literature review was performed using the search engines: Pubmed, Science-direct, Ovid and Scopus. |
| first_indexed | 2024-04-13T08:19:27Z |
| format | Article |
| id | doaj.art-b2905f589ab8403ab94771cd3ee76bd0 |
| institution | Directory Open Access Journal |
| issn | 1677-5538 1677-6119 |
| language | English |
| last_indexed | 2024-04-13T08:19:27Z |
| publishDate | 2012-10-01 |
| publisher | Sociedade Brasileira de Urologia |
| record_format | Article |
| series | International Brazilian Journal of Urology |
| spelling | doaj.art-b2905f589ab8403ab94771cd3ee76bd02022-12-22T02:54:42ZengSociedade Brasileira de UrologiaInternational Brazilian Journal of Urology1677-55381677-61192012-10-0138557659410.1590/S1677-55382012000500002Unexplained Male infertility: diagnosis and ManagementAlaa HamadaSandro C. EstevesMark NizzaAshok AgarwalUnexplained male infertility is a diagnosis reserved for men in whom routine semen analyses results are within normal values and physical as well as endocrine abnormalities were ruled out. In addition to erectile problems and coital factors, immunologic causes and sperm dysfunction may contribute to such condition. New etiologies of unexplained male infertility include low level leukocytospermia and mitochondrial DNA polymerase gene polymorphism. Contemporary andrology may reveal cellular and sub-cellular sperm dysfunctions which may explain subfertility in such cases, thus aiding the clinician to direct the further work-up, diagnosis and counseling of the infertile male. The objective of this article is to highlight the concept of unexplained male infertility and focuses on the diagnosis and treatment of this condition in the era of modern andrology and assisted reproductive techniques. Extensive literature review was performed using the search engines: Pubmed, Science-direct, Ovid and Scopus.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382012000500002Male infertilityDiagnosis, Semen analysisOxidative stressDNA damageReproductive Techniques, Assisted |
| spellingShingle | Alaa Hamada Sandro C. Esteves Mark Nizza Ashok Agarwal Unexplained Male infertility: diagnosis and Management International Brazilian Journal of Urology Male infertility Diagnosis, Semen analysis Oxidative stress DNA damage Reproductive Techniques, Assisted |
| title | Unexplained Male infertility: diagnosis and Management |
| title_full | Unexplained Male infertility: diagnosis and Management |
| title_fullStr | Unexplained Male infertility: diagnosis and Management |
| title_full_unstemmed | Unexplained Male infertility: diagnosis and Management |
| title_short | Unexplained Male infertility: diagnosis and Management |
| title_sort | unexplained male infertility diagnosis and management |
| topic | Male infertility Diagnosis, Semen analysis Oxidative stress DNA damage Reproductive Techniques, Assisted |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382012000500002 |
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