Cas12a Base Editors Induce Efficient and Specific Editing with Low DNA Damage Response

Cas12a Base Editors Induce Efficient and Specific Editing with Low DNA Damage Response

Summary: The advent of base editors (BEs) holds great potential for correcting pathogenic-related point mutations to treat relevant diseases. However, Cas9 nickase (nCas9)-derived BEs lead to DNA double-strand breaks, which can trigger unwanted DNA damage response (DDR). Here, we show that the origi...

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Bibliographic Details
Main Authors: Xiao Wang, Chengfeng Ding, Wenxia Yu, Ying Wang, Siting He, Bei Yang, Yi-Chun Xiong, Jia Wei, Jifang Li, Jiayi Liang, Zongyang Lu, Wei Zhu, Jing Wu, Zhi Zhou, Xingxu Huang, Zhen Liu, Li Yang, Jia Chen
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720307002

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