Anaemia in the first week may be associated with long-term mortality among critically ill patients: propensity score-based analyses
Abstract Background Anaemia is highly prevalent in critically ill patients; however, the long-term effect on mortality remains unclear. Methods We retrospectively included patients admitted to the medical intensive care units (ICUs) during 2015–2020 at the Taichung Veterans General Hospital. The pri...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | BMC Emergency Medicine |
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| Online Access: | https://doi.org/10.1186/s12873-023-00806-w |
| _version_ | 1797860043627954176 |
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| author | I-Hung Lin Pei-Ya Liao Li-Ting Wong Ming-Cheng Chan Chieh-Liang Wu Wen-Cheng Chao |
| author_facet | I-Hung Lin Pei-Ya Liao Li-Ting Wong Ming-Cheng Chan Chieh-Liang Wu Wen-Cheng Chao |
| author_sort | I-Hung Lin |
| collection | DOAJ |
| description | Abstract Background Anaemia is highly prevalent in critically ill patients; however, the long-term effect on mortality remains unclear. Methods We retrospectively included patients admitted to the medical intensive care units (ICUs) during 2015–2020 at the Taichung Veterans General Hospital. The primary outcome of interest was one-year mortality, and hazard ratios (HRs) with 95% confidence intervals (CIs) were determined to assess the association. We used propensity score matching (PSM) and propensity score matching methods, including inverse probability of treatment weighting (IPTW) as well as covariate balancing propensity score (CBPS), in the present study. Results A total of 7,089 patients were eligible for analyses, and 45.0% (3,189/7,089) of them had anaemia, defined by mean levels of haemoglobin being less than 10 g/dL. The standardised difference of covariates in this study were lower than 0.20 after matching and weighting. The application of CBPS further reduced the imbalance among covariates. We demonstrated a similar association, and adjusted HRs in original, PSM, IPTW and CBPS populations were 1.345 (95% CI 1.227–1.474), 1.265 (95% CI 1.145–1.397), 1.276 (95% CI 1.142–1.427) and 1.260 (95% CI 1.125–1.411), respectively. Conclusions We used propensity score-based analyses to identify that anaemia within the first week was associated with increased one-year mortality in critically ill patients. |
| first_indexed | 2024-04-09T21:39:21Z |
| format | Article |
| id | doaj.art-b29324dc656b43feba719919420759a8 |
| institution | Directory Open Access Journal |
| issn | 1471-227X |
| language | English |
| last_indexed | 2024-04-09T21:39:21Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Emergency Medicine |
| spelling | doaj.art-b29324dc656b43feba719919420759a82023-03-26T11:07:33ZengBMCBMC Emergency Medicine1471-227X2023-03-012311910.1186/s12873-023-00806-wAnaemia in the first week may be associated with long-term mortality among critically ill patients: propensity score-based analysesI-Hung Lin0Pei-Ya Liao1Li-Ting Wong2Ming-Cheng Chan3Chieh-Liang Wu4Wen-Cheng Chao5Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General HospitalDivision of Chest Medicine, Department of Internal Medicine, Taichung Veterans General HospitalDepartment of Medical Research, Taichung Veterans General HospitalDivision of Critical Care and Respiratory Therapy, Department of Internal Medicine, Taichung Veterans General HospitalDepartment of Critical Care Medicine, Taichung Veterans General HospitalDepartment of Critical Care Medicine, Taichung Veterans General HospitalAbstract Background Anaemia is highly prevalent in critically ill patients; however, the long-term effect on mortality remains unclear. Methods We retrospectively included patients admitted to the medical intensive care units (ICUs) during 2015–2020 at the Taichung Veterans General Hospital. The primary outcome of interest was one-year mortality, and hazard ratios (HRs) with 95% confidence intervals (CIs) were determined to assess the association. We used propensity score matching (PSM) and propensity score matching methods, including inverse probability of treatment weighting (IPTW) as well as covariate balancing propensity score (CBPS), in the present study. Results A total of 7,089 patients were eligible for analyses, and 45.0% (3,189/7,089) of them had anaemia, defined by mean levels of haemoglobin being less than 10 g/dL. The standardised difference of covariates in this study were lower than 0.20 after matching and weighting. The application of CBPS further reduced the imbalance among covariates. We demonstrated a similar association, and adjusted HRs in original, PSM, IPTW and CBPS populations were 1.345 (95% CI 1.227–1.474), 1.265 (95% CI 1.145–1.397), 1.276 (95% CI 1.142–1.427) and 1.260 (95% CI 1.125–1.411), respectively. Conclusions We used propensity score-based analyses to identify that anaemia within the first week was associated with increased one-year mortality in critically ill patients.https://doi.org/10.1186/s12873-023-00806-wAnaemiaLong-term outcomeCritical illnessPropensity score |
| spellingShingle | I-Hung Lin Pei-Ya Liao Li-Ting Wong Ming-Cheng Chan Chieh-Liang Wu Wen-Cheng Chao Anaemia in the first week may be associated with long-term mortality among critically ill patients: propensity score-based analyses BMC Emergency Medicine Anaemia Long-term outcome Critical illness Propensity score |
| title | Anaemia in the first week may be associated with long-term mortality among critically ill patients: propensity score-based analyses |
| title_full | Anaemia in the first week may be associated with long-term mortality among critically ill patients: propensity score-based analyses |
| title_fullStr | Anaemia in the first week may be associated with long-term mortality among critically ill patients: propensity score-based analyses |
| title_full_unstemmed | Anaemia in the first week may be associated with long-term mortality among critically ill patients: propensity score-based analyses |
| title_short | Anaemia in the first week may be associated with long-term mortality among critically ill patients: propensity score-based analyses |
| title_sort | anaemia in the first week may be associated with long term mortality among critically ill patients propensity score based analyses |
| topic | Anaemia Long-term outcome Critical illness Propensity score |
| url | https://doi.org/10.1186/s12873-023-00806-w |
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