Discrete Survival Model Analysis of <i>Plasmodium falciparum</i> Response to Artemisinin-Based Combination Therapies among Children in Regions of Varying Malaria Transmission in Cameroon
The need to monitor changes in parasite clearance following treatment with artemisinin-based combination therapies (ACTs) is important in the containment of drug resistance. This study aimed to model <i>Plasmodium falciparum</i> response to ACTs among children in two different transmissi...
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| Format: | Article |
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MDPI AG
2021-08-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/10/9/1106 |
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| author | Akindeh M. Nji Innocent M. Ali Peter Thelma Ngwa Niba Evehe Marie-Solange Christian Heumann Guenter Froeschl Wilfred F. Mbacham |
| author_facet | Akindeh M. Nji Innocent M. Ali Peter Thelma Ngwa Niba Evehe Marie-Solange Christian Heumann Guenter Froeschl Wilfred F. Mbacham |
| author_sort | Akindeh M. Nji |
| collection | DOAJ |
| description | The need to monitor changes in parasite clearance following treatment with artemisinin-based combination therapies (ACTs) is important in the containment of drug resistance. This study aimed to model <i>Plasmodium falciparum</i> response to ACTs among children in two different transmission settings (Mutengene and Garoua) in Cameroon. Using the step function, a discrete-time survival model was fitted with all the covariates included that might play a role in parasite clearance. The probability of clearing parasites within 24 h following treatment was 21.6% and 70.3% for younger children aged 6 to 59 months and 29.3% and 59.8% for older children aged 60 to 120 months in Mutengene and Garoua, respectively. After two days of treatment, the conditional probability of clearing parasites given that they were not cleared on day 1 was 76.7% and 96.6% for children aged 6–59 months and 83.1% and 93.5% for children aged 60–120 months in Mutengene and Garoua, respectively. The model demonstrated that the ecological setting, age group and pretreatment serum levels of creatinine and alanine aminotransferase were the main factors that significantly influenced parasite clearance in vivo after administration of ACTs (<i>p</i> < 0.05). The findings highlight the need for further investigations on host differential response to ACTs in current practice. |
| first_indexed | 2024-03-10T07:19:32Z |
| format | Article |
| id | doaj.art-b29366f4538c48329be3a77b9850b945 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T07:19:32Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-b29366f4538c48329be3a77b9850b9452023-11-22T14:41:49ZengMDPI AGPathogens2076-08172021-08-01109110610.3390/pathogens10091106Discrete Survival Model Analysis of <i>Plasmodium falciparum</i> Response to Artemisinin-Based Combination Therapies among Children in Regions of Varying Malaria Transmission in CameroonAkindeh M. Nji0Innocent M. Ali1Peter Thelma Ngwa Niba2Evehe Marie-Solange3Christian Heumann4Guenter Froeschl5Wilfred F. Mbacham6The Biotechnology Center, University of Yaoundé I, Yaoundé BP 8094, CameroonThe Biotechnology Center, University of Yaoundé I, Yaoundé BP 8094, CameroonThe Biotechnology Center, University of Yaoundé I, Yaoundé BP 8094, CameroonThe Biotechnology Center, University of Yaoundé I, Yaoundé BP 8094, CameroonDepartment of Statistics, Ludwig Maximilian University of Munich, 80802 Munich, GermanyCenter for International Health, Ludwig Maximilian University of Munich, 80802 Munich, GermanyThe Biotechnology Center, University of Yaoundé I, Yaoundé BP 8094, CameroonThe need to monitor changes in parasite clearance following treatment with artemisinin-based combination therapies (ACTs) is important in the containment of drug resistance. This study aimed to model <i>Plasmodium falciparum</i> response to ACTs among children in two different transmission settings (Mutengene and Garoua) in Cameroon. Using the step function, a discrete-time survival model was fitted with all the covariates included that might play a role in parasite clearance. The probability of clearing parasites within 24 h following treatment was 21.6% and 70.3% for younger children aged 6 to 59 months and 29.3% and 59.8% for older children aged 60 to 120 months in Mutengene and Garoua, respectively. After two days of treatment, the conditional probability of clearing parasites given that they were not cleared on day 1 was 76.7% and 96.6% for children aged 6–59 months and 83.1% and 93.5% for children aged 60–120 months in Mutengene and Garoua, respectively. The model demonstrated that the ecological setting, age group and pretreatment serum levels of creatinine and alanine aminotransferase were the main factors that significantly influenced parasite clearance in vivo after administration of ACTs (<i>p</i> < 0.05). The findings highlight the need for further investigations on host differential response to ACTs in current practice.https://www.mdpi.com/2076-0817/10/9/1106<i>Plasmodium</i> <i>falciparum</i>parasite clearancechildrenACTdiscrete timesurvival model |
| spellingShingle | Akindeh M. Nji Innocent M. Ali Peter Thelma Ngwa Niba Evehe Marie-Solange Christian Heumann Guenter Froeschl Wilfred F. Mbacham Discrete Survival Model Analysis of <i>Plasmodium falciparum</i> Response to Artemisinin-Based Combination Therapies among Children in Regions of Varying Malaria Transmission in Cameroon Pathogens <i>Plasmodium</i> <i>falciparum</i> parasite clearance children ACT discrete time survival model |
| title | Discrete Survival Model Analysis of <i>Plasmodium falciparum</i> Response to Artemisinin-Based Combination Therapies among Children in Regions of Varying Malaria Transmission in Cameroon |
| title_full | Discrete Survival Model Analysis of <i>Plasmodium falciparum</i> Response to Artemisinin-Based Combination Therapies among Children in Regions of Varying Malaria Transmission in Cameroon |
| title_fullStr | Discrete Survival Model Analysis of <i>Plasmodium falciparum</i> Response to Artemisinin-Based Combination Therapies among Children in Regions of Varying Malaria Transmission in Cameroon |
| title_full_unstemmed | Discrete Survival Model Analysis of <i>Plasmodium falciparum</i> Response to Artemisinin-Based Combination Therapies among Children in Regions of Varying Malaria Transmission in Cameroon |
| title_short | Discrete Survival Model Analysis of <i>Plasmodium falciparum</i> Response to Artemisinin-Based Combination Therapies among Children in Regions of Varying Malaria Transmission in Cameroon |
| title_sort | discrete survival model analysis of i plasmodium falciparum i response to artemisinin based combination therapies among children in regions of varying malaria transmission in cameroon |
| topic | <i>Plasmodium</i> <i>falciparum</i> parasite clearance children ACT discrete time survival model |
| url | https://www.mdpi.com/2076-0817/10/9/1106 |
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