Alterations of Specific Lymphocytic Subsets with Aging and Age-Related Metabolic and Cardiovascular Diseases
To investigate the association of immunosenescence with aged-related morbidity in the elderly, a clinical study was conducted to analyze and compare the alterations in peripheral blood (PB) T-cell subsets among young healthy (YH) controls, elderly healthy (EH) controls, and age-matched elderly patie...
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MDPI AG
2020-10-01
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| Online Access: | https://www.mdpi.com/2075-1729/10/10/246 |
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| author | Ying Jen Chen Yi Jen Liao Van Thi Ngoc Tram Chung Hao Lin Kuo Chen Liao Chao Lien Liu |
| author_facet | Ying Jen Chen Yi Jen Liao Van Thi Ngoc Tram Chung Hao Lin Kuo Chen Liao Chao Lien Liu |
| author_sort | Ying Jen Chen |
| collection | DOAJ |
| description | To investigate the association of immunosenescence with aged-related morbidity in the elderly, a clinical study was conducted to analyze and compare the alterations in peripheral blood (PB) T-cell subsets among young healthy (YH) controls, elderly healthy (EH) controls, and age-matched elderly patients with metabolic diseases (E-MDs), with cardiovascular diseases (E-CVDs) or with both (E-MDs/E-CVDs). The frequencies of CD3T, CD8T and invariant natural killer T (iNKT) cells were decreased in the EH, E-MD and E-CVD cohorts, indicating a decline in defense function. Although CD4T and regulatory T (Treg) cell frequencies tended to increase with aging, they were lower in patients with E-MDs and E-CVDs. Subset analyses of T-cells consistently showed the accumulation of senescent T-cell in aging and in patients with E-MDs and E-CVDs, compared with YH volunteers. These accumulated senescent T-cells were undergoing apoptosis upon stimulation due to the replicative senescence stage of T-cells. In addition, serum levels of cytokines, including interferon (IF)-γ, transforming growth factor (TGF)-β and growth differentiation factor (GDF)-15, consistently reflected alterations in T-cell subsets. This study demonstrated that T-cell subset changes with paralleled alterations in cytokines were associated with aging and age-related pathogenesis. These altered T-cell subsets and/or cytokines can potentially serve as biomarkers for the prevention, diagnosis and treatment of age-related morbidities. |
| first_indexed | 2024-03-10T15:32:46Z |
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| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T15:32:46Z |
| publishDate | 2020-10-01 |
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| series | Life |
| spelling | doaj.art-b29382beddaa4fe1ad73a19a38b98bff2023-11-20T17:28:46ZengMDPI AGLife2075-17292020-10-01101024610.3390/life10100246Alterations of Specific Lymphocytic Subsets with Aging and Age-Related Metabolic and Cardiovascular DiseasesYing Jen Chen0Yi Jen Liao1Van Thi Ngoc Tram2Chung Hao Lin3Kuo Chen Liao4Chao Lien Liu5Division of General Internal Medicine and Geriatrics, Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan 33305, TaiwanSchool of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, TaiwanSchool of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, TaiwanDivision of General Internal Medicine and Geriatrics, Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan 33305, TaiwanDivision of General Internal Medicine and Geriatrics, Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan 33305, TaiwanSchool of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, TaiwanTo investigate the association of immunosenescence with aged-related morbidity in the elderly, a clinical study was conducted to analyze and compare the alterations in peripheral blood (PB) T-cell subsets among young healthy (YH) controls, elderly healthy (EH) controls, and age-matched elderly patients with metabolic diseases (E-MDs), with cardiovascular diseases (E-CVDs) or with both (E-MDs/E-CVDs). The frequencies of CD3T, CD8T and invariant natural killer T (iNKT) cells were decreased in the EH, E-MD and E-CVD cohorts, indicating a decline in defense function. Although CD4T and regulatory T (Treg) cell frequencies tended to increase with aging, they were lower in patients with E-MDs and E-CVDs. Subset analyses of T-cells consistently showed the accumulation of senescent T-cell in aging and in patients with E-MDs and E-CVDs, compared with YH volunteers. These accumulated senescent T-cells were undergoing apoptosis upon stimulation due to the replicative senescence stage of T-cells. In addition, serum levels of cytokines, including interferon (IF)-γ, transforming growth factor (TGF)-β and growth differentiation factor (GDF)-15, consistently reflected alterations in T-cell subsets. This study demonstrated that T-cell subset changes with paralleled alterations in cytokines were associated with aging and age-related pathogenesis. These altered T-cell subsets and/or cytokines can potentially serve as biomarkers for the prevention, diagnosis and treatment of age-related morbidities.https://www.mdpi.com/2075-1729/10/10/246agingE-MDsE-CVDsimmunosenescenceT<sub>EM</sub>T<sub>EMRA</sub> |
| spellingShingle | Ying Jen Chen Yi Jen Liao Van Thi Ngoc Tram Chung Hao Lin Kuo Chen Liao Chao Lien Liu Alterations of Specific Lymphocytic Subsets with Aging and Age-Related Metabolic and Cardiovascular Diseases Life aging E-MDs E-CVDs immunosenescence T<sub>EM</sub> T<sub>EMRA</sub> |
| title | Alterations of Specific Lymphocytic Subsets with Aging and Age-Related Metabolic and Cardiovascular Diseases |
| title_full | Alterations of Specific Lymphocytic Subsets with Aging and Age-Related Metabolic and Cardiovascular Diseases |
| title_fullStr | Alterations of Specific Lymphocytic Subsets with Aging and Age-Related Metabolic and Cardiovascular Diseases |
| title_full_unstemmed | Alterations of Specific Lymphocytic Subsets with Aging and Age-Related Metabolic and Cardiovascular Diseases |
| title_short | Alterations of Specific Lymphocytic Subsets with Aging and Age-Related Metabolic and Cardiovascular Diseases |
| title_sort | alterations of specific lymphocytic subsets with aging and age related metabolic and cardiovascular diseases |
| topic | aging E-MDs E-CVDs immunosenescence T<sub>EM</sub> T<sub>EMRA</sub> |
| url | https://www.mdpi.com/2075-1729/10/10/246 |
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