Immune Modulation in Critically Ill Septic Patients
Sepsis is triggered by infection-induced immune alteration and may be theoretically improved by pharmacological and extracorporeal immune modulating therapies. Pharmacological immune modulation may have long lasting clinical effects, that may even worsen patient-related outcomes. On the other hand,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/6/552 |
| _version_ | 1797531939312238592 |
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| author | Salvatore Lucio Cutuli Simone Carelli Domenico Luca Grieco Gennaro De Pascale |
| author_facet | Salvatore Lucio Cutuli Simone Carelli Domenico Luca Grieco Gennaro De Pascale |
| author_sort | Salvatore Lucio Cutuli |
| collection | DOAJ |
| description | Sepsis is triggered by infection-induced immune alteration and may be theoretically improved by pharmacological and extracorporeal immune modulating therapies. Pharmacological immune modulation may have long lasting clinical effects, that may even worsen patient-related outcomes. On the other hand, extracorporeal immune modulation allows short-term removal of inflammatory mediators from the bloodstream. Although such therapies have been widely used in clinical practice, the role of immune modulation in critically ill septic patients remains unclear and little evidence supports the role of immune modulation in this clinical context. Accordingly, further research should be carried out by an evidence-based and personalized approach in order to improve the management of critically ill septic patients. |
| first_indexed | 2024-03-10T10:51:57Z |
| format | Article |
| id | doaj.art-b294765273bd465cbda043144c4dfdec |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T10:51:57Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-b294765273bd465cbda043144c4dfdec2023-11-21T22:10:03ZengMDPI AGMedicina1010-660X1648-91442021-05-0157655210.3390/medicina57060552Immune Modulation in Critically Ill Septic PatientsSalvatore Lucio Cutuli0Simone Carelli1Domenico Luca Grieco2Gennaro De Pascale3Dipartimento di Scienze dell’ Emergenza, Anestesiologiche e della Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyDipartimento di Scienze dell’ Emergenza, Anestesiologiche e della Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyDipartimento di Scienze dell’ Emergenza, Anestesiologiche e della Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyDipartimento di Scienze dell’ Emergenza, Anestesiologiche e della Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalySepsis is triggered by infection-induced immune alteration and may be theoretically improved by pharmacological and extracorporeal immune modulating therapies. Pharmacological immune modulation may have long lasting clinical effects, that may even worsen patient-related outcomes. On the other hand, extracorporeal immune modulation allows short-term removal of inflammatory mediators from the bloodstream. Although such therapies have been widely used in clinical practice, the role of immune modulation in critically ill septic patients remains unclear and little evidence supports the role of immune modulation in this clinical context. Accordingly, further research should be carried out by an evidence-based and personalized approach in order to improve the management of critically ill septic patients.https://www.mdpi.com/1648-9144/57/6/552sepsisseptic shockinfectionextracorporeal immune modulationblood purificationrenal replacement therapy |
| spellingShingle | Salvatore Lucio Cutuli Simone Carelli Domenico Luca Grieco Gennaro De Pascale Immune Modulation in Critically Ill Septic Patients Medicina sepsis septic shock infection extracorporeal immune modulation blood purification renal replacement therapy |
| title | Immune Modulation in Critically Ill Septic Patients |
| title_full | Immune Modulation in Critically Ill Septic Patients |
| title_fullStr | Immune Modulation in Critically Ill Septic Patients |
| title_full_unstemmed | Immune Modulation in Critically Ill Septic Patients |
| title_short | Immune Modulation in Critically Ill Septic Patients |
| title_sort | immune modulation in critically ill septic patients |
| topic | sepsis septic shock infection extracorporeal immune modulation blood purification renal replacement therapy |
| url | https://www.mdpi.com/1648-9144/57/6/552 |
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