Impact of previous infection and body mass index on interferon-gamma and immunoglobulin G level generated against three types of vaccines available in Iraq
Background: Due to increased vaccination rates and the continued spread of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) virus, many people are developing “hybrid immunity” to the virus. On the other hand, a high body mass index (BMI) has been associated with a reduced immune resp...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Biomedical and Biotechnology Research Journal |
| Subjects: | |
| Online Access: | http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2022;volume=6;issue=4;spage=576;epage=581;aulast=Hassan |
| _version_ | 1797955085669498880 |
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| author | Rawaq Taleb Hassan Suhad Hadi Mohammed |
| author_facet | Rawaq Taleb Hassan Suhad Hadi Mohammed |
| author_sort | Rawaq Taleb Hassan |
| collection | DOAJ |
| description | Background: Due to increased vaccination rates and the continued spread of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) virus, many people are developing “hybrid immunity” to the virus. On the other hand, a high body mass index (BMI) has been associated with a reduced immune response to vaccination.the aims of this study was to measuring the level of immunoglobulin G (IgG) and interferon-gamma (IFN-γ) generated against different types of vaccines in vaccinated individuals with and without previous infection and with BMI. a cross-sectional study was conducted between November 2021 and April 2022. Methods: A blood sample was obtained from 174 vaccinated persons. SARS-CoV-2 IgG levels and IFN-γ were detected using SARS-CoV-2 IgG II quant and ELISAtechniques, respectively. statistical Analysis Used IBM SPSS version 24 software was used. Quantitative results are indicated as mean ± standard deviation. The statistical significance level was set at P < 0.05. Results: There was no statistically significant difference in IgG and IFN-γ mean levels between the vaccinated individual with and without confirmed previous infection. However, there was a significant difference in the case of the AstraZeneca vaccine regarding IgG levels only. The mean antibody concentration of patients with normal weight who received the Pfizer vaccine showed a slightly significant difference. Regarding the IFN-γ level, there was a significant difference among the three types of vaccines in obese individuals. Conclusion: Previous infection with coronavirus disease-2019 seems to have no effect on IgG and IFN-γ levels after vaccination. In addition, normal-weight individuals might possibly respond better to the vaccine and produce more antibody levels. |
| first_indexed | 2024-04-10T23:28:46Z |
| format | Article |
| id | doaj.art-b296312f552e46b09d978eb7b18c11cc |
| institution | Directory Open Access Journal |
| issn | 2588-9834 2588-9842 |
| language | English |
| last_indexed | 2024-04-10T23:28:46Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Biomedical and Biotechnology Research Journal |
| spelling | doaj.art-b296312f552e46b09d978eb7b18c11cc2023-01-12T11:21:07ZengWolters Kluwer Medknow PublicationsBiomedical and Biotechnology Research Journal2588-98342588-98422022-01-016457658110.4103/bbrj.bbrj_291_22Impact of previous infection and body mass index on interferon-gamma and immunoglobulin G level generated against three types of vaccines available in IraqRawaq Taleb HassanSuhad Hadi MohammedBackground: Due to increased vaccination rates and the continued spread of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) virus, many people are developing “hybrid immunity” to the virus. On the other hand, a high body mass index (BMI) has been associated with a reduced immune response to vaccination.the aims of this study was to measuring the level of immunoglobulin G (IgG) and interferon-gamma (IFN-γ) generated against different types of vaccines in vaccinated individuals with and without previous infection and with BMI. a cross-sectional study was conducted between November 2021 and April 2022. Methods: A blood sample was obtained from 174 vaccinated persons. SARS-CoV-2 IgG levels and IFN-γ were detected using SARS-CoV-2 IgG II quant and ELISAtechniques, respectively. statistical Analysis Used IBM SPSS version 24 software was used. Quantitative results are indicated as mean ± standard deviation. The statistical significance level was set at P < 0.05. Results: There was no statistically significant difference in IgG and IFN-γ mean levels between the vaccinated individual with and without confirmed previous infection. However, there was a significant difference in the case of the AstraZeneca vaccine regarding IgG levels only. The mean antibody concentration of patients with normal weight who received the Pfizer vaccine showed a slightly significant difference. Regarding the IFN-γ level, there was a significant difference among the three types of vaccines in obese individuals. Conclusion: Previous infection with coronavirus disease-2019 seems to have no effect on IgG and IFN-γ levels after vaccination. In addition, normal-weight individuals might possibly respond better to the vaccine and produce more antibody levels.http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2022;volume=6;issue=4;spage=576;epage=581;aulast=Hassanastrazenecacoronavirus disease-2019interferon-gammaimmunoglobulin gpfizersinopharm |
| spellingShingle | Rawaq Taleb Hassan Suhad Hadi Mohammed Impact of previous infection and body mass index on interferon-gamma and immunoglobulin G level generated against three types of vaccines available in Iraq Biomedical and Biotechnology Research Journal astrazeneca coronavirus disease-2019 interferon-gamma immunoglobulin g pfizer sinopharm |
| title | Impact of previous infection and body mass index on interferon-gamma and immunoglobulin G level generated against three types of vaccines available in Iraq |
| title_full | Impact of previous infection and body mass index on interferon-gamma and immunoglobulin G level generated against three types of vaccines available in Iraq |
| title_fullStr | Impact of previous infection and body mass index on interferon-gamma and immunoglobulin G level generated against three types of vaccines available in Iraq |
| title_full_unstemmed | Impact of previous infection and body mass index on interferon-gamma and immunoglobulin G level generated against three types of vaccines available in Iraq |
| title_short | Impact of previous infection and body mass index on interferon-gamma and immunoglobulin G level generated against three types of vaccines available in Iraq |
| title_sort | impact of previous infection and body mass index on interferon gamma and immunoglobulin g level generated against three types of vaccines available in iraq |
| topic | astrazeneca coronavirus disease-2019 interferon-gamma immunoglobulin g pfizer sinopharm |
| url | http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2022;volume=6;issue=4;spage=576;epage=581;aulast=Hassan |
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