‘Messy’ Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency

‘Messy’ Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency

Integrated venomics techniques have shown that variable processing of conotoxins from Conus marmoreus resulted in a dramatic expansion in the number of expressed conotoxins. One conotoxin from C. marmoreus, the χ-conotoxin MrIA, is a selective inhibitor of human norepinephrine transporters (...

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Bibliographic Details
Main Authors: Rebekah Ziegman, Andreas Brust, Prerna Jha, Fernanda C. Cardoso, Richard J. Lewis, Paul F. Alewood
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Marine Drugs
Subjects:
conotoxin
MrIA
peptides
Norepinephrine Transporter Inhibitor (NET)
bioactivity
Online Access:http://www.mdpi.com/1660-3397/17/3/165

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