Vitiligo—Thyroid Disease Association: When, in Whom, and Why Should It Be Suspected? A Systematic Review
In most dermatological pathologies, the phenomena observed on the skin are a reflection of internal disorders. In patients with associated acral involvement on the dorsal sides of the hands, this “vitiligo phenotype” may lead to the investigation of certain associated pathologies that sometimes have...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/12/2048 |
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| author | Ana Maria Chivu Elena Bălășescu Larisa Diana Pandia Roxana Ioana Nedelcu Alice Brînzea Gabriela Turcu Mihaela Antohe Daniela Adriana Ion |
| author_facet | Ana Maria Chivu Elena Bălășescu Larisa Diana Pandia Roxana Ioana Nedelcu Alice Brînzea Gabriela Turcu Mihaela Antohe Daniela Adriana Ion |
| author_sort | Ana Maria Chivu |
| collection | DOAJ |
| description | In most dermatological pathologies, the phenomena observed on the skin are a reflection of internal disorders. In patients with associated acral involvement on the dorsal sides of the hands, this “vitiligo phenotype” may lead to the investigation of certain associated pathologies that sometimes have no obvious clinical impact. To assess the link between skin depigmentation and autoimmune pathologies, we conducted a systematic review involving article selection from the PubMed database. Patients with coexisting thyroid pathologies were found to have a predisposition for developing acral vitiligo and depigmentation of the wrists, and autoimmune thyroid pathologies appeared to be the only coexisting autoimmune or inflammatory diseases in vitiligo patients to show a pattern of distribution. The association of concomitant thyroid dysfunction with depigmentation of the hands was found to be so strong that the absence of depigmented macules on the hands may exclude the coexistence of an autoimmune thyroid pathology. Although the frequency of acral involvement in patients with vitiligo and autoimmune pathologies is higher, the mechanism by which thyroid dysfunction influences this distribution pattern remains incompletely elucidated and requires future studies. |
| first_indexed | 2024-03-09T16:13:09Z |
| format | Article |
| id | doaj.art-b2975d2a11b6420e8a812f62f2fdc43a |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T16:13:09Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-b2975d2a11b6420e8a812f62f2fdc43a2023-11-24T16:02:43ZengMDPI AGJournal of Personalized Medicine2075-44262022-12-011212204810.3390/jpm12122048Vitiligo—Thyroid Disease Association: When, in Whom, and Why Should It Be Suspected? A Systematic ReviewAna Maria Chivu0Elena Bălășescu1Larisa Diana Pandia2Roxana Ioana Nedelcu3Alice Brînzea4Gabriela Turcu5Mihaela Antohe6Daniela Adriana Ion72nd Pathophysiology Department, Laboratory of Experimental Medicine and Fundamental Research, Carol Davila University of Medicine and Pharmacy, 37 Dionisie Lupu Street, District 2, 020021 Bucharest, Romania2nd Pathophysiology Department, Laboratory of Experimental Medicine and Fundamental Research, Carol Davila University of Medicine and Pharmacy, 37 Dionisie Lupu Street, District 2, 020021 Bucharest, RomaniaAstera Diamed Diabetes & Nutrition and Endocrinology Clinic, 010161 Bucharest, Romania2nd Pathophysiology Department, Laboratory of Experimental Medicine and Fundamental Research, Carol Davila University of Medicine and Pharmacy, 37 Dionisie Lupu Street, District 2, 020021 Bucharest, Romania2nd Pathophysiology Department, Laboratory of Experimental Medicine and Fundamental Research, Carol Davila University of Medicine and Pharmacy, 37 Dionisie Lupu Street, District 2, 020021 Bucharest, Romania2nd Pathophysiology Department, Laboratory of Experimental Medicine and Fundamental Research, Carol Davila University of Medicine and Pharmacy, 37 Dionisie Lupu Street, District 2, 020021 Bucharest, Romania2nd Pathophysiology Department, Laboratory of Experimental Medicine and Fundamental Research, Carol Davila University of Medicine and Pharmacy, 37 Dionisie Lupu Street, District 2, 020021 Bucharest, Romania2nd Pathophysiology Department, Laboratory of Experimental Medicine and Fundamental Research, Carol Davila University of Medicine and Pharmacy, 37 Dionisie Lupu Street, District 2, 020021 Bucharest, RomaniaIn most dermatological pathologies, the phenomena observed on the skin are a reflection of internal disorders. In patients with associated acral involvement on the dorsal sides of the hands, this “vitiligo phenotype” may lead to the investigation of certain associated pathologies that sometimes have no obvious clinical impact. To assess the link between skin depigmentation and autoimmune pathologies, we conducted a systematic review involving article selection from the PubMed database. Patients with coexisting thyroid pathologies were found to have a predisposition for developing acral vitiligo and depigmentation of the wrists, and autoimmune thyroid pathologies appeared to be the only coexisting autoimmune or inflammatory diseases in vitiligo patients to show a pattern of distribution. The association of concomitant thyroid dysfunction with depigmentation of the hands was found to be so strong that the absence of depigmented macules on the hands may exclude the coexistence of an autoimmune thyroid pathology. Although the frequency of acral involvement in patients with vitiligo and autoimmune pathologies is higher, the mechanism by which thyroid dysfunction influences this distribution pattern remains incompletely elucidated and requires future studies.https://www.mdpi.com/2075-4426/12/12/2048vitiligothyroid pathologyautoimmune pathologiespathophysiology |
| spellingShingle | Ana Maria Chivu Elena Bălășescu Larisa Diana Pandia Roxana Ioana Nedelcu Alice Brînzea Gabriela Turcu Mihaela Antohe Daniela Adriana Ion Vitiligo—Thyroid Disease Association: When, in Whom, and Why Should It Be Suspected? A Systematic Review Journal of Personalized Medicine vitiligo thyroid pathology autoimmune pathologies pathophysiology |
| title | Vitiligo—Thyroid Disease Association: When, in Whom, and Why Should It Be Suspected? A Systematic Review |
| title_full | Vitiligo—Thyroid Disease Association: When, in Whom, and Why Should It Be Suspected? A Systematic Review |
| title_fullStr | Vitiligo—Thyroid Disease Association: When, in Whom, and Why Should It Be Suspected? A Systematic Review |
| title_full_unstemmed | Vitiligo—Thyroid Disease Association: When, in Whom, and Why Should It Be Suspected? A Systematic Review |
| title_short | Vitiligo—Thyroid Disease Association: When, in Whom, and Why Should It Be Suspected? A Systematic Review |
| title_sort | vitiligo thyroid disease association when in whom and why should it be suspected a systematic review |
| topic | vitiligo thyroid pathology autoimmune pathologies pathophysiology |
| url | https://www.mdpi.com/2075-4426/12/12/2048 |
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