Effect of donor graft quality on clinical outcomes after penetrating keratoplasty for keratoconus
Purpose: To evaluate the effect of donor and eye bank characteristics on graft rating and clinical outcomes after penetrating keratoplasty (PK) for keratoconus. Methods: This retrospective interventional case series included 252 keratoconic eyes which underwent PK. Donor data included age and sex, c...
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| Format: | Article |
| Language: | English |
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Knowledge E
2015-01-01
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| Series: | Journal of Ophthalmic & Vision Research |
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| Online Access: | http://www.jovr.org/article.asp?issn=2008-322X;year=2015;volume=10;issue=4;spage=364;epage=369;aulast=Feizi |
| _version_ | 1811192935835762688 |
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| author | Sepehr Feizi Mohammad Ali Javadi Hassan Ghasemi Fatemeh Javadi |
| author_facet | Sepehr Feizi Mohammad Ali Javadi Hassan Ghasemi Fatemeh Javadi |
| author_sort | Sepehr Feizi |
| collection | DOAJ |
| description | Purpose: To evaluate the effect of donor and eye bank characteristics on graft rating and clinical outcomes after penetrating keratoplasty (PK) for keratoconus.
Methods: This retrospective interventional case series included 252 keratoconic eyes which underwent PK. Donor data included age and sex, cause of death, death-to-preservation time, preservation-to-surgery time, epithelial and stromal status, endothelial cell density (ECD) and morphology, and graft rating. Postoperative outcomes included visual acuity, refractive error, epithelial problems, suture-related complications, graft rejection, and graft transparency. Multivariate regression analysis assessed correlations between donor and eye bank characteristics and graft quality, and postoperative outcomes.
Results: Mean recipient and donor age was 29.7 ± 10.0 and 26.2 ± 8.8 years, respectively and mean follow-up period was 66.7 ± 38.5 months. Death-to-preservation time was significantly associated with the presence of graft epithelial sloughing (P = 0.005) and stromal cloudiness (P < 0.001). Donor age significantly influenced ECD (P = 0.02), mean cell area (P = 0.04), and hexagonality (P = 0.01). The presence of epithelial defects on postoperative day 1 correlated significantly with death-to-preservation time (P = 0.004). Graft stromal edema on postoperative day 1 was significantly associated with graft epithelial sloughing (P < 0.001). Postoperative visual and refractive outcomes, complications, and graft survival were not correlated with any donor or eye bank factors.
Conclusion: Donor and eye bank variables affected the quality of donor corneas and early postoperative course. However, their long term effect on clinical outcomes, complications, and graft survival were insignificant. |
| first_indexed | 2024-04-11T23:59:25Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2008-322X |
| language | English |
| last_indexed | 2024-04-11T23:59:25Z |
| publishDate | 2015-01-01 |
| publisher | Knowledge E |
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| series | Journal of Ophthalmic & Vision Research |
| spelling | doaj.art-b2984bcb4bc84ed9aac65408b0149f852022-12-22T03:56:16ZengKnowledge EJournal of Ophthalmic & Vision Research2008-322X2015-01-0110436436910.4103/2008-322X.176912Effect of donor graft quality on clinical outcomes after penetrating keratoplasty for keratoconusSepehr FeiziMohammad Ali JavadiHassan GhasemiFatemeh JavadiPurpose: To evaluate the effect of donor and eye bank characteristics on graft rating and clinical outcomes after penetrating keratoplasty (PK) for keratoconus. Methods: This retrospective interventional case series included 252 keratoconic eyes which underwent PK. Donor data included age and sex, cause of death, death-to-preservation time, preservation-to-surgery time, epithelial and stromal status, endothelial cell density (ECD) and morphology, and graft rating. Postoperative outcomes included visual acuity, refractive error, epithelial problems, suture-related complications, graft rejection, and graft transparency. Multivariate regression analysis assessed correlations between donor and eye bank characteristics and graft quality, and postoperative outcomes. Results: Mean recipient and donor age was 29.7 ± 10.0 and 26.2 ± 8.8 years, respectively and mean follow-up period was 66.7 ± 38.5 months. Death-to-preservation time was significantly associated with the presence of graft epithelial sloughing (P = 0.005) and stromal cloudiness (P < 0.001). Donor age significantly influenced ECD (P = 0.02), mean cell area (P = 0.04), and hexagonality (P = 0.01). The presence of epithelial defects on postoperative day 1 correlated significantly with death-to-preservation time (P = 0.004). Graft stromal edema on postoperative day 1 was significantly associated with graft epithelial sloughing (P < 0.001). Postoperative visual and refractive outcomes, complications, and graft survival were not correlated with any donor or eye bank factors. Conclusion: Donor and eye bank variables affected the quality of donor corneas and early postoperative course. However, their long term effect on clinical outcomes, complications, and graft survival were insignificant.http://www.jovr.org/article.asp?issn=2008-322X;year=2015;volume=10;issue=4;spage=364;epage=369;aulast=FeiziDonor Quality; Keratoconus; Penetrating Keratoplasty; Postoperative Outcomes |
| spellingShingle | Sepehr Feizi Mohammad Ali Javadi Hassan Ghasemi Fatemeh Javadi Effect of donor graft quality on clinical outcomes after penetrating keratoplasty for keratoconus Journal of Ophthalmic & Vision Research Donor Quality; Keratoconus; Penetrating Keratoplasty; Postoperative Outcomes |
| title | Effect of donor graft quality on clinical outcomes after penetrating keratoplasty for keratoconus |
| title_full | Effect of donor graft quality on clinical outcomes after penetrating keratoplasty for keratoconus |
| title_fullStr | Effect of donor graft quality on clinical outcomes after penetrating keratoplasty for keratoconus |
| title_full_unstemmed | Effect of donor graft quality on clinical outcomes after penetrating keratoplasty for keratoconus |
| title_short | Effect of donor graft quality on clinical outcomes after penetrating keratoplasty for keratoconus |
| title_sort | effect of donor graft quality on clinical outcomes after penetrating keratoplasty for keratoconus |
| topic | Donor Quality; Keratoconus; Penetrating Keratoplasty; Postoperative Outcomes |
| url | http://www.jovr.org/article.asp?issn=2008-322X;year=2015;volume=10;issue=4;spage=364;epage=369;aulast=Feizi |
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