HIV, HTLV, and Hepatitis B and C Infection in Blood Donors in Bahia, Brazil from 2008 to 2017
Although blood transfusion is an important therapeutic resource, transfusion-transmitted infections (TTIs) are still a cause for concern. Measures to mitigate this risk involve improvement of donor screening criteria and improvements in laboratory tests, especially the use of nucleic acid test (NAT)...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/11/2323 |
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| author | Estela Luz Marinho Marques Eduardo Martins Netto Luisa Meireles Campos Sávio Amaral Iraildes Santana Eduardo Luz Marques Carlos Brites |
| author_facet | Estela Luz Marinho Marques Eduardo Martins Netto Luisa Meireles Campos Sávio Amaral Iraildes Santana Eduardo Luz Marques Carlos Brites |
| author_sort | Estela Luz |
| collection | DOAJ |
| description | Although blood transfusion is an important therapeutic resource, transfusion-transmitted infections (TTIs) are still a cause for concern. Measures to mitigate this risk involve improvement of donor screening criteria and improvements in laboratory tests, especially the use of nucleic acid test (NAT). In this retrospective study we evaluated HIV, HTLV, HCV and HBV infection rates in blood donors of the Hematology and Hemotherapy Foundation of Bahia (Hemoba), Brazil, through serological and NAT results and the characteristics of donors. From February/2008 to December/2017, 777,446 blood donations were made. Most donors were male, aged 25–44 years, black and mixed race, and single or divorced. The density-type incidence (DTI; per 100,000) for each virus was 91.1 for HBV; 66.5 for HCV; 54.3 for HIV; and 33.9 for HTLV, with a decreasing trend observed over the period studied, except in the last biennium. NAT detected only 1 donor in immunological window for HIV (0.46/100,000 donations) and 3 donors in immunological window for HBV (1.8/100,000 donations). Serological positivity for all viruses studied was higher in the metropolitan region of Salvador, the state capital. Conclusion: DTI rates show a decreasing trend over the years studied, with a predominance of HBV infection. NAT allowed the detection of donors in immunological window periods, having an important role in improving transfusion safety. |
| first_indexed | 2024-03-09T18:34:34Z |
| format | Article |
| id | doaj.art-b2987c1428734482bed29e2107ba5cdb |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T18:34:34Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-b2987c1428734482bed29e2107ba5cdb2023-11-24T07:15:24ZengMDPI AGViruses1999-49152022-10-011411232310.3390/v14112323HIV, HTLV, and Hepatitis B and C Infection in Blood Donors in Bahia, Brazil from 2008 to 2017Estela Luz0Marinho Marques1Eduardo Martins Netto2Luisa Meireles Campos3Sávio Amaral4Iraildes Santana5Eduardo Luz Marques6Carlos Brites7Programa de Pós-Graduação em Medicina e Saúde, Universidade Federal da Bahia, Salvador 40110-060, BA, BrazilFundação de Hematologia e Hemoterapia da Bahia, Salvador 40286-240, BA, BrazilPrograma de Pós-Graduação em Medicina e Saúde, Universidade Federal da Bahia, Salvador 40110-060, BA, BrazilEscola Bahiana de Medicina e Saúde Pública, Salvador 40290-000, BA, BrazilPrograma de Pós-Graduação em Medicina e Saúde, Universidade Federal da Bahia, Salvador 40110-060, BA, BrazilFundação de Hematologia e Hemoterapia da Bahia, Salvador 40286-240, BA, BrazilEscola Bahiana de Medicina e Saúde Pública, Salvador 40290-000, BA, BrazilPrograma de Pós-Graduação em Medicina e Saúde, Universidade Federal da Bahia, Salvador 40110-060, BA, BrazilAlthough blood transfusion is an important therapeutic resource, transfusion-transmitted infections (TTIs) are still a cause for concern. Measures to mitigate this risk involve improvement of donor screening criteria and improvements in laboratory tests, especially the use of nucleic acid test (NAT). In this retrospective study we evaluated HIV, HTLV, HCV and HBV infection rates in blood donors of the Hematology and Hemotherapy Foundation of Bahia (Hemoba), Brazil, through serological and NAT results and the characteristics of donors. From February/2008 to December/2017, 777,446 blood donations were made. Most donors were male, aged 25–44 years, black and mixed race, and single or divorced. The density-type incidence (DTI; per 100,000) for each virus was 91.1 for HBV; 66.5 for HCV; 54.3 for HIV; and 33.9 for HTLV, with a decreasing trend observed over the period studied, except in the last biennium. NAT detected only 1 donor in immunological window for HIV (0.46/100,000 donations) and 3 donors in immunological window for HBV (1.8/100,000 donations). Serological positivity for all viruses studied was higher in the metropolitan region of Salvador, the state capital. Conclusion: DTI rates show a decreasing trend over the years studied, with a predominance of HBV infection. NAT allowed the detection of donors in immunological window periods, having an important role in improving transfusion safety.https://www.mdpi.com/1999-4915/14/11/2323HIVHTLVHCVHBVblood donorstransfusion-transmitted infections |
| spellingShingle | Estela Luz Marinho Marques Eduardo Martins Netto Luisa Meireles Campos Sávio Amaral Iraildes Santana Eduardo Luz Marques Carlos Brites HIV, HTLV, and Hepatitis B and C Infection in Blood Donors in Bahia, Brazil from 2008 to 2017 Viruses HIV HTLV HCV HBV blood donors transfusion-transmitted infections |
| title | HIV, HTLV, and Hepatitis B and C Infection in Blood Donors in Bahia, Brazil from 2008 to 2017 |
| title_full | HIV, HTLV, and Hepatitis B and C Infection in Blood Donors in Bahia, Brazil from 2008 to 2017 |
| title_fullStr | HIV, HTLV, and Hepatitis B and C Infection in Blood Donors in Bahia, Brazil from 2008 to 2017 |
| title_full_unstemmed | HIV, HTLV, and Hepatitis B and C Infection in Blood Donors in Bahia, Brazil from 2008 to 2017 |
| title_short | HIV, HTLV, and Hepatitis B and C Infection in Blood Donors in Bahia, Brazil from 2008 to 2017 |
| title_sort | hiv htlv and hepatitis b and c infection in blood donors in bahia brazil from 2008 to 2017 |
| topic | HIV HTLV HCV HBV blood donors transfusion-transmitted infections |
| url | https://www.mdpi.com/1999-4915/14/11/2323 |
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