Comparative pharmacoeconomic analysis of ceffaroline fosamil in the treatment of complicated skin and soft tissues infections
The objective was to evaluate the cost-effectiveness and budget impact of ceftaroline fosamil compared with other intravenous antibiotics with anti-MRSA activity in the treatment of complicated skin and soft tissue infections (cSSTI). The source of data on the efficacy and safety were randomized con...
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| Format: | Article |
| Language: | Russian |
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Izdatelstvo OKI
2018-05-01
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| Series: | Качественная клиническая практика |
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| Online Access: | https://www.clinvest.ru/jour/article/view/26 |
| _version_ | 1797262133336997888 |
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| author | S. K. Zyryanov D. Yu. Belousov E. V. Afanasyeva |
| author_facet | S. K. Zyryanov D. Yu. Belousov E. V. Afanasyeva |
| author_sort | S. K. Zyryanov |
| collection | DOAJ |
| description | The objective was to evaluate the cost-effectiveness and budget impact of ceftaroline fosamil compared with other intravenous antibiotics with anti-MRSA activity in the treatment of complicated skin and soft tissue infections (cSSTI). The source of data on the efficacy and safety were randomized controlled trials and meta-analyzes devoted to the study of drugs for the treatment cSSTI. Comparison drugs were daptomycin, tigecycline, vancomycin and linezolid. To “overlap” gram-negative infections for vancomycin, linezolid and daptomycin was taken into account levofloxacin and cefoperazone/sulbactam with the share of each of them at 50%. For the efficacy was taken clinical response at day 7-14 after a course of treatment in ITT-population of patients with cSSTI. We calculated the direct medical and indirect non-medical costs associated with premature mortality. The data obtained are the following types of pharmacoeconomic analysis: cost-effectiveness analysis (CEA), budget impact analysis (BIA) and sensitivity analysis (SA). The results of pharmacoeconomic analyzes have shown that the cost-effectiveness ratio (CER) per patient was lowest in vancomycin - 79.613 rub., further follow: ceftaroline - 94.474 rub., linezolid - 118.049 rub., tigecycline - 122.424 rub. and daptomycin - 127.484 rub. Evaluation of cost-effectiveness threshold demonstrated that CER do not exceed the value of “willingness-to-pay ratio” none of the comparators, i.e., they are subject to state reimbursement under the compulsory health insurance system. Analysis of indirect costs per patient associated with premature mortality and the shortfall in GDP gave the following results: at ceftaroline they accounted for 31.391 rub., daptomycin - 78.458 rub., tigecycline - 105.688 rub., linezolid - 151.880 rub., vancomycin - 187.774 rub. The total costs (direct and indirect) per patient were at least in ceftaroline group - 108.094 rub., further follow: daptomycin - 182.102 rub., tigecycline - 203.493 rub., vancomycin - 251.743 rub. and linezolid - 252.151 rub. BIA shows that the transition from comparators to ceftaroline is costs saving overall of the budget: with linezolid - 144.056 rub., vancomycin - 143.649 rub., tigecycline - 95.399 rub., daptomycin - 74.008 rub. SA confirmed these results. Ceftaroline is the best alternative to daptomycin, tigecycline, vancomycin and linezolid. Active implementation of ceftaroline as a drug for the treatment of cSSTI can contribute both to optimize budget spending at various levels. |
| first_indexed | 2024-04-24T23:52:16Z |
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| issn | 2588-0519 2618-8473 |
| language | Russian |
| last_indexed | 2024-04-24T23:52:16Z |
| publishDate | 2018-05-01 |
| publisher | Izdatelstvo OKI |
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| series | Качественная клиническая практика |
| spelling | doaj.art-b2989bcdb62e4515a356753c3abceadb2024-03-14T18:09:03ZrusIzdatelstvo OKIКачественная клиническая практика2588-05192618-84732018-05-0103435926Comparative pharmacoeconomic analysis of ceffaroline fosamil in the treatment of complicated skin and soft tissues infectionsS. K. Zyryanov0D. Yu. Belousov1E. V. Afanasyeva2ФГАОУ ВО «Российский университет дружбы народов», г. МоскваООО "Центр фармакоэкономических исследований", г. МоскваООО "Центр фармакоэкономических исследований", г. МоскваThe objective was to evaluate the cost-effectiveness and budget impact of ceftaroline fosamil compared with other intravenous antibiotics with anti-MRSA activity in the treatment of complicated skin and soft tissue infections (cSSTI). The source of data on the efficacy and safety were randomized controlled trials and meta-analyzes devoted to the study of drugs for the treatment cSSTI. Comparison drugs were daptomycin, tigecycline, vancomycin and linezolid. To “overlap” gram-negative infections for vancomycin, linezolid and daptomycin was taken into account levofloxacin and cefoperazone/sulbactam with the share of each of them at 50%. For the efficacy was taken clinical response at day 7-14 after a course of treatment in ITT-population of patients with cSSTI. We calculated the direct medical and indirect non-medical costs associated with premature mortality. The data obtained are the following types of pharmacoeconomic analysis: cost-effectiveness analysis (CEA), budget impact analysis (BIA) and sensitivity analysis (SA). The results of pharmacoeconomic analyzes have shown that the cost-effectiveness ratio (CER) per patient was lowest in vancomycin - 79.613 rub., further follow: ceftaroline - 94.474 rub., linezolid - 118.049 rub., tigecycline - 122.424 rub. and daptomycin - 127.484 rub. Evaluation of cost-effectiveness threshold demonstrated that CER do not exceed the value of “willingness-to-pay ratio” none of the comparators, i.e., they are subject to state reimbursement under the compulsory health insurance system. Analysis of indirect costs per patient associated with premature mortality and the shortfall in GDP gave the following results: at ceftaroline they accounted for 31.391 rub., daptomycin - 78.458 rub., tigecycline - 105.688 rub., linezolid - 151.880 rub., vancomycin - 187.774 rub. The total costs (direct and indirect) per patient were at least in ceftaroline group - 108.094 rub., further follow: daptomycin - 182.102 rub., tigecycline - 203.493 rub., vancomycin - 251.743 rub. and linezolid - 252.151 rub. BIA shows that the transition from comparators to ceftaroline is costs saving overall of the budget: with linezolid - 144.056 rub., vancomycin - 143.649 rub., tigecycline - 95.399 rub., daptomycin - 74.008 rub. SA confirmed these results. Ceftaroline is the best alternative to daptomycin, tigecycline, vancomycin and linezolid. Active implementation of ceftaroline as a drug for the treatment of cSSTI can contribute both to optimize budget spending at various levels.https://www.clinvest.ru/jour/article/view/26осложнённые инфекции кожи и мягких тканейфармакоэкономикацефтаролина фосамилдаптомицинтигециклинванкомицинлинезолидматематическое моделированиеанализ эффективности затратанализ влияния на бюджетcomplicated skin and soft tissue infectionspharmacoeconomicsceftaroline fosamildaptomycintigecyclinevancomycinlinezolidmathematical modelingcost-effectiveness analysisbudget impact analysis |
| spellingShingle | S. K. Zyryanov D. Yu. Belousov E. V. Afanasyeva Comparative pharmacoeconomic analysis of ceffaroline fosamil in the treatment of complicated skin and soft tissues infections Качественная клиническая практика осложнённые инфекции кожи и мягких тканей фармакоэкономика цефтаролина фосамил даптомицин тигециклин ванкомицин линезолид математическое моделирование анализ эффективности затрат анализ влияния на бюджет complicated skin and soft tissue infections pharmacoeconomics ceftaroline fosamil daptomycin tigecycline vancomycin linezolid mathematical modeling cost-effectiveness analysis budget impact analysis |
| title | Comparative pharmacoeconomic analysis of ceffaroline fosamil in the treatment of complicated skin and soft tissues infections |
| title_full | Comparative pharmacoeconomic analysis of ceffaroline fosamil in the treatment of complicated skin and soft tissues infections |
| title_fullStr | Comparative pharmacoeconomic analysis of ceffaroline fosamil in the treatment of complicated skin and soft tissues infections |
| title_full_unstemmed | Comparative pharmacoeconomic analysis of ceffaroline fosamil in the treatment of complicated skin and soft tissues infections |
| title_short | Comparative pharmacoeconomic analysis of ceffaroline fosamil in the treatment of complicated skin and soft tissues infections |
| title_sort | comparative pharmacoeconomic analysis of ceffaroline fosamil in the treatment of complicated skin and soft tissues infections |
| topic | осложнённые инфекции кожи и мягких тканей фармакоэкономика цефтаролина фосамил даптомицин тигециклин ванкомицин линезолид математическое моделирование анализ эффективности затрат анализ влияния на бюджет complicated skin and soft tissue infections pharmacoeconomics ceftaroline fosamil daptomycin tigecycline vancomycin linezolid mathematical modeling cost-effectiveness analysis budget impact analysis |
| url | https://www.clinvest.ru/jour/article/view/26 |
| work_keys_str_mv | AT skzyryanov comparativepharmacoeconomicanalysisofceffarolinefosamilinthetreatmentofcomplicatedskinandsofttissuesinfections AT dyubelousov comparativepharmacoeconomicanalysisofceffarolinefosamilinthetreatmentofcomplicatedskinandsofttissuesinfections AT evafanasyeva comparativepharmacoeconomicanalysisofceffarolinefosamilinthetreatmentofcomplicatedskinandsofttissuesinfections |