Changes in pneumococcal serotypes distribution and penicillin resistance in healthy children five years after generalization of PCV10
Objective: Streptococcus pneumoniae (S. pneumoniae) nasopharyngeal carriage has significantly decreased after the generalization of pneumococcal vaccination worldwide. This study sought to investigate changes in S. pneumoniae carriage rates, serotype distribution and penicillin non-susceptibility fo...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024017729 |
| _version_ | 1797267833813467136 |
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| author | Karima Warda Sara Amari Majda Boureddane Youssef Elkamouni Lamiae Arsalane Said Zouhair Mohammed Bouskraoui |
| author_facet | Karima Warda Sara Amari Majda Boureddane Youssef Elkamouni Lamiae Arsalane Said Zouhair Mohammed Bouskraoui |
| author_sort | Karima Warda |
| collection | DOAJ |
| description | Objective: Streptococcus pneumoniae (S. pneumoniae) nasopharyngeal carriage has significantly decreased after the generalization of pneumococcal vaccination worldwide. This study sought to investigate changes in S. pneumoniae carriage rates, serotype distribution and penicillin non-susceptibility following the generalization of 10-valent pneumococcal conjugate vaccine. Methods: A prospective study was conducted in Marrakesh, Morocco, between 2017 and 2018, among healthy children attending vaccination centers. We collected nasopharyngeal swabs and questionnaire data for each child. Using univariate logistic regression, we analyzed the association between S. pneumoniae carriage and various risk factors. Comparisons of serotype diversity and penicillin resistance between 2017 and 2018 and the period before introduction of vaccination (2008–2009, n = 660) were performed using Simpson index and the chi-squared test, respectively. Results: During 2017–2018, 515 children aged between 6 and 36 months participated. The S. pneumoniae carriage rate was 43.3%. Looking at the distribution serotypes, the rate of PCV10 serotypes rate was only 9.6%. Among non-vaccine serotypes, an increase in serotypes 6C/6D (22; 14%), 19B/19C (17; 10.8%), and 15B/15C (11; 7%) was observed. A particular increase in serotype diversity was also observed after the generalization of PCV10 (p < 0.001). S. pneumoniae non-susceptible to penicillin decreased, reaching a rate of 26.6% in 2017–2018. Conclusion: The significant change in S. pneumoniae carriage, serotype distribution, and penicillin resistance highlights the effectiveness of the pneumococcal conjugate vaccine among children in Marrakesh, Morocco. |
| first_indexed | 2024-03-08T00:49:20Z |
| format | Article |
| id | doaj.art-b29a61e56fd14230b731e8906450e972 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-25T01:22:52Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-b29a61e56fd14230b731e8906450e9722024-03-09T09:26:05ZengElsevierHeliyon2405-84402024-02-01104e25741Changes in pneumococcal serotypes distribution and penicillin resistance in healthy children five years after generalization of PCV10Karima Warda0Sara Amari1Majda Boureddane2Youssef Elkamouni3Lamiae Arsalane4Said Zouhair5Mohammed Bouskraoui6Laboratory of Microbiology and Virology, Cadi Ayad University, Marrakesh, Morocco; Corresponding author.Laboratory of Microbiology and Virology, Cadi Ayad University, Marrakesh, MoroccoLaboratory of Microbiology and Virology, Cadi Ayad University, Marrakesh, MoroccoLaboratory of Microbiology and Virology, Cadi Ayad University, Marrakesh, Morocco; Laboratory of Microbiology-Virology and Molecular Biology, Avicenna Military Hospital, Marrakesh, MoroccoLaboratory of Microbiology and Virology, Cadi Ayad University, Marrakesh, Morocco; Laboratory of Microbiology-Virology and Molecular Biology, Avicenna Military Hospital, Marrakesh, MoroccoLaboratory of Microbiology and Virology, Cadi Ayad University, Marrakesh, Morocco; Laboratory of Microbiology-Virology and Molecular Biology, Avicenna Military Hospital, Marrakesh, MoroccoLaboratory of Microbiology and Virology, Cadi Ayad University, Marrakesh, Morocco; Department of Pediatrics, Mohamed VI University Hospital Center, Marrakesh, MoroccoObjective: Streptococcus pneumoniae (S. pneumoniae) nasopharyngeal carriage has significantly decreased after the generalization of pneumococcal vaccination worldwide. This study sought to investigate changes in S. pneumoniae carriage rates, serotype distribution and penicillin non-susceptibility following the generalization of 10-valent pneumococcal conjugate vaccine. Methods: A prospective study was conducted in Marrakesh, Morocco, between 2017 and 2018, among healthy children attending vaccination centers. We collected nasopharyngeal swabs and questionnaire data for each child. Using univariate logistic regression, we analyzed the association between S. pneumoniae carriage and various risk factors. Comparisons of serotype diversity and penicillin resistance between 2017 and 2018 and the period before introduction of vaccination (2008–2009, n = 660) were performed using Simpson index and the chi-squared test, respectively. Results: During 2017–2018, 515 children aged between 6 and 36 months participated. The S. pneumoniae carriage rate was 43.3%. Looking at the distribution serotypes, the rate of PCV10 serotypes rate was only 9.6%. Among non-vaccine serotypes, an increase in serotypes 6C/6D (22; 14%), 19B/19C (17; 10.8%), and 15B/15C (11; 7%) was observed. A particular increase in serotype diversity was also observed after the generalization of PCV10 (p < 0.001). S. pneumoniae non-susceptible to penicillin decreased, reaching a rate of 26.6% in 2017–2018. Conclusion: The significant change in S. pneumoniae carriage, serotype distribution, and penicillin resistance highlights the effectiveness of the pneumococcal conjugate vaccine among children in Marrakesh, Morocco.http://www.sciencedirect.com/science/article/pii/S2405844024017729NasopharyngealCarriageS. pneumoniaePenicillin resistancePCV10 |
| spellingShingle | Karima Warda Sara Amari Majda Boureddane Youssef Elkamouni Lamiae Arsalane Said Zouhair Mohammed Bouskraoui Changes in pneumococcal serotypes distribution and penicillin resistance in healthy children five years after generalization of PCV10 Heliyon Nasopharyngeal Carriage S. pneumoniae Penicillin resistance PCV10 |
| title | Changes in pneumococcal serotypes distribution and penicillin resistance in healthy children five years after generalization of PCV10 |
| title_full | Changes in pneumococcal serotypes distribution and penicillin resistance in healthy children five years after generalization of PCV10 |
| title_fullStr | Changes in pneumococcal serotypes distribution and penicillin resistance in healthy children five years after generalization of PCV10 |
| title_full_unstemmed | Changes in pneumococcal serotypes distribution and penicillin resistance in healthy children five years after generalization of PCV10 |
| title_short | Changes in pneumococcal serotypes distribution and penicillin resistance in healthy children five years after generalization of PCV10 |
| title_sort | changes in pneumococcal serotypes distribution and penicillin resistance in healthy children five years after generalization of pcv10 |
| topic | Nasopharyngeal Carriage S. pneumoniae Penicillin resistance PCV10 |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024017729 |
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