An investigation of Plk1 PBD inhibitor KBJK557 as a tumor growth suppressor in non-small cell lung cancer

An investigation of Plk1 PBD inhibitor KBJK557 as a tumor growth suppressor in non-small cell lung cancer

Abstract Lung cancer is the second most commonly reported type of cancer worldwide. Approximately 80–85% of lung cancer occurrences are accounted by non-small cell lung cancer (NSCLC). Polo-like kinase-1 (Plk1) plays multiple roles in cell cycle progression and its overexpression is observed in majo...

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Bibliographic Details
Main Authors: Pethaiah Gunasekaran, Gong-Hyeon Lee, Yeon Sil Hwang, Bon-Chul Koo, Eun Hee Han, Guel Bang, Yeo Kyung La, Sunghyun Park, Hak Nam Kim, Mi-Hyun Kim, Jeong Kyu Bang, Eun Kyoung Ryu
Format: Article
Language:English
Published: SpringerOpen 2022-10-01
Series:Journal of Analytical Science and Technology
Subjects:
Lung cancer
Polo-like kinase-1
Polo box domain
KBJK557
Inhibitor
Online Access:https://doi.org/10.1186/s40543-022-00345-2

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