Levels of oxidative stress in patients with neoadjuvant chemotherapy for gastric cancer: correlation with treatment response
ObjectiveThe intent of this study was to investigate the relationship between oxidative stress and treatment response in gastric cancer patients undergoing neoadjuvant chemotherapy.MethodsBlood samples from 108 patients and 108 healthy subjects were collected, and all patients were enrolled in SOX c...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1192192/full |
| _version_ | 1827944703359713280 |
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| author | Jiatong Lu Shaoyu Guan Jiajun Luo Jiajun Luo Jingwen Yuan Junfeng Yan Chen Yang Qiang Tong |
| author_facet | Jiatong Lu Shaoyu Guan Jiajun Luo Jiajun Luo Jingwen Yuan Junfeng Yan Chen Yang Qiang Tong |
| author_sort | Jiatong Lu |
| collection | DOAJ |
| description | ObjectiveThe intent of this study was to investigate the relationship between oxidative stress and treatment response in gastric cancer patients undergoing neoadjuvant chemotherapy.MethodsBlood samples from 108 patients and 108 healthy subjects were collected, and all patients were enrolled in SOX chemotherapy. The patients received four cycles of neoadjuvant chemotherapy. Blood samples were collected to determine oxidative stress levels at baseline prior to beginning chemotherapy, and at the end of cycles 2 and 4. The patients receiving neoadjuvant chemotherapy were followed up for several months to years. A survival curve was created according to the follow-up information from the patients. In addition, the correlation between oxidative stress level and treatment effect was evaluated and ROC curves were plotted according to the final collected data.ResultsCompared with the normal group, the levels of the antioxidant index decreased while the peroxide index increased in the patients. Conversely, when patients were compared before and after chemotherapy, the antioxidant index increased but the peroxide index decreased. Furthermore, the antioxidant index increased in the response group while the peroxide index decreased in the non-response group.ConclusionPatients with an increased antioxidant index after chemotherapy have good treatment responsiveness. These indicators can also be used as predictors to judge the patients’ response to chemotherapy. |
| first_indexed | 2024-03-13T10:34:17Z |
| format | Article |
| id | doaj.art-b29c1449176849c4b7cdef1f42d74ef4 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-13T10:34:17Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-b29c1449176849c4b7cdef1f42d74ef42023-05-18T08:05:08ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-05-011310.3389/fonc.2023.11921921192192Levels of oxidative stress in patients with neoadjuvant chemotherapy for gastric cancer: correlation with treatment responseJiatong Lu0Shaoyu Guan1Jiajun Luo2Jiajun Luo3Jingwen Yuan4Junfeng Yan5Chen Yang6Qiang Tong7Department of Gastrointestinal Surgery I Section, Renmin Hospital of Wuhan University, Wuhan, China93868 Troop of the Chinese People's Liberation Army (PLA), Yinchuan, ChinaDepartment of Gastrointestinal Surgery I Section, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Gastrointestinal Surgery, The Sixth Hospital of Wuhan, The Affiliated Hospital of Jianghan University, Wuhan, ChinaDepartment of Gastrointestinal Surgery I Section, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Gastrointestinal Surgery I Section, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Gastrointestinal Surgery I Section, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Gastrointestinal Surgery I Section, Renmin Hospital of Wuhan University, Wuhan, ChinaObjectiveThe intent of this study was to investigate the relationship between oxidative stress and treatment response in gastric cancer patients undergoing neoadjuvant chemotherapy.MethodsBlood samples from 108 patients and 108 healthy subjects were collected, and all patients were enrolled in SOX chemotherapy. The patients received four cycles of neoadjuvant chemotherapy. Blood samples were collected to determine oxidative stress levels at baseline prior to beginning chemotherapy, and at the end of cycles 2 and 4. The patients receiving neoadjuvant chemotherapy were followed up for several months to years. A survival curve was created according to the follow-up information from the patients. In addition, the correlation between oxidative stress level and treatment effect was evaluated and ROC curves were plotted according to the final collected data.ResultsCompared with the normal group, the levels of the antioxidant index decreased while the peroxide index increased in the patients. Conversely, when patients were compared before and after chemotherapy, the antioxidant index increased but the peroxide index decreased. Furthermore, the antioxidant index increased in the response group while the peroxide index decreased in the non-response group.ConclusionPatients with an increased antioxidant index after chemotherapy have good treatment responsiveness. These indicators can also be used as predictors to judge the patients’ response to chemotherapy.https://www.frontiersin.org/articles/10.3389/fonc.2023.1192192/fullgastric canceroxidative stressneoadjuvant chemotherapychemotherapy responsivenesspredictors |
| spellingShingle | Jiatong Lu Shaoyu Guan Jiajun Luo Jiajun Luo Jingwen Yuan Junfeng Yan Chen Yang Qiang Tong Levels of oxidative stress in patients with neoadjuvant chemotherapy for gastric cancer: correlation with treatment response Frontiers in Oncology gastric cancer oxidative stress neoadjuvant chemotherapy chemotherapy responsiveness predictors |
| title | Levels of oxidative stress in patients with neoadjuvant chemotherapy for gastric cancer: correlation with treatment response |
| title_full | Levels of oxidative stress in patients with neoadjuvant chemotherapy for gastric cancer: correlation with treatment response |
| title_fullStr | Levels of oxidative stress in patients with neoadjuvant chemotherapy for gastric cancer: correlation with treatment response |
| title_full_unstemmed | Levels of oxidative stress in patients with neoadjuvant chemotherapy for gastric cancer: correlation with treatment response |
| title_short | Levels of oxidative stress in patients with neoadjuvant chemotherapy for gastric cancer: correlation with treatment response |
| title_sort | levels of oxidative stress in patients with neoadjuvant chemotherapy for gastric cancer correlation with treatment response |
| topic | gastric cancer oxidative stress neoadjuvant chemotherapy chemotherapy responsiveness predictors |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1192192/full |
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