In vivo CRISPR screens reveal potent driver mutations in head and neck cancers
We have recently tested the transforming potential of 484 ‘long-tail’ genes, which are recurrently albeit infrequently mutated in head and neck cancers (HNSCC). We identified 15 novel tumor suppressors and our top hits converge on regulating the NOTCH signaling pathway. Therapeutic approaches activa...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-07-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2020.1758541 |
| _version_ | 1827809362429607936 |
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| author | Sampath Kumar Loganathan Daniel Schramek |
| author_facet | Sampath Kumar Loganathan Daniel Schramek |
| author_sort | Sampath Kumar Loganathan |
| collection | DOAJ |
| description | We have recently tested the transforming potential of 484 ‘long-tail’ genes, which are recurrently albeit infrequently mutated in head and neck cancers (HNSCC). We identified 15 novel tumor suppressors and our top hits converge on regulating the NOTCH signaling pathway. Therapeutic approaches activating NOTCH signaling could be a promising strategy to treat two-thirds of human HNSCC patients. |
| first_indexed | 2024-03-11T22:40:08Z |
| format | Article |
| id | doaj.art-b29cc4ae3ca947e785db706d7fbc28b3 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:08Z |
| publishDate | 2020-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-b29cc4ae3ca947e785db706d7fbc28b32023-09-22T09:11:02ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562020-07-017410.1080/23723556.2020.17585411758541In vivo CRISPR screens reveal potent driver mutations in head and neck cancersSampath Kumar Loganathan0Daniel Schramek1Lunenfeld-Tanenbaum Research Institute, Mount Sinai HospitalLunenfeld-Tanenbaum Research Institute, Mount Sinai HospitalWe have recently tested the transforming potential of 484 ‘long-tail’ genes, which are recurrently albeit infrequently mutated in head and neck cancers (HNSCC). We identified 15 novel tumor suppressors and our top hits converge on regulating the NOTCH signaling pathway. Therapeutic approaches activating NOTCH signaling could be a promising strategy to treat two-thirds of human HNSCC patients.http://dx.doi.org/10.1080/23723556.2020.1758541hnsccnotchmouse models of cancerlong-tail genesin vivo crispr |
| spellingShingle | Sampath Kumar Loganathan Daniel Schramek In vivo CRISPR screens reveal potent driver mutations in head and neck cancers Molecular & Cellular Oncology hnscc notch mouse models of cancer long-tail genes in vivo crispr |
| title | In vivo CRISPR screens reveal potent driver mutations in head and neck cancers |
| title_full | In vivo CRISPR screens reveal potent driver mutations in head and neck cancers |
| title_fullStr | In vivo CRISPR screens reveal potent driver mutations in head and neck cancers |
| title_full_unstemmed | In vivo CRISPR screens reveal potent driver mutations in head and neck cancers |
| title_short | In vivo CRISPR screens reveal potent driver mutations in head and neck cancers |
| title_sort | in vivo crispr screens reveal potent driver mutations in head and neck cancers |
| topic | hnscc notch mouse models of cancer long-tail genes in vivo crispr |
| url | http://dx.doi.org/10.1080/23723556.2020.1758541 |
| work_keys_str_mv | AT sampathkumarloganathan invivocrisprscreensrevealpotentdrivermutationsinheadandneckcancers AT danielschramek invivocrisprscreensrevealpotentdrivermutationsinheadandneckcancers |