Changes of photopic negative response of multifocal electroretinogram after treatment with Aflibercept in patients with diabetic macular edema
AIM:To observe the changes of photopic negative response(PhNR)of multifocal electroretinogram(mf-ERG)in patients with diabetic macular edema(DME)before and after treatment with Aflibercept.METHODS: A total of 37 patients(37 eyes)with DME who visited the Aier Eye Hospital of Wuhan University(Wuhan Ai...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2023-11-01
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| Series: | Guoji Yanke Zazhi |
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| Online Access: | http://ies.ijo.cn/cn_publish/2023/11/202311028.pdf |
| _version_ | 1797652609125842944 |
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| author | Chong Xu Chao Feng Jian-Hua Wu |
| author_facet | Chong Xu Chao Feng Jian-Hua Wu |
| author_sort | Chong Xu |
| collection | DOAJ |
| description | AIM:To observe the changes of photopic negative response(PhNR)of multifocal electroretinogram(mf-ERG)in patients with diabetic macular edema(DME)before and after treatment with Aflibercept.METHODS: A total of 37 patients(37 eyes)with DME who visited the Aier Eye Hospital of Wuhan University(Wuhan Aier Eye Hospital)from May 2019 to June 2022, and 0.05 mL of aflibercept was injected per month for consecutive 3mo were included in this retrospective cohort study. Another 20 cases(20 eyes)with normal physical examination to exclude related eye diseases were selected as the control group. The PhNR amplitude of mf-ERG, best-corrected visual acuity(BCVA; LogMAR), central retinal thickness(CRT), capillary plexus in macular area and vessel density(CPVD)of the participants between the two groups were compared before and after treatment.RESULTS: The PhNR amplitude of mf-ERG in DME patients before treatment(201.69±80.92nV)was significantly lower than that in the normal control group(398.87±77.92nV; P<0.01), and the average PhNR amplitude of mf-ERG in DME patients at 6mo after treatment was significantly higher than that before treatment(P=0.036), but it was still significantly lower than the normal control group at 6mo after treatment(P=0.031). In addition, the BCVA(LogMAR)of DME patients increased from 0.64±1.33 to 0.37±1.39(P=0.021)at 6mo after treatment, and CPVD significantly increased compared to that before treatment(P=0.029). Meanwhile, the PhNR amplitude of mf-ERG in DME patients at 6mo after treatment was positively correlated with CPVD at 6mo after treatment(r=0.448, P=0.043), and negatively correlated with BCVA(LogMAR)and CRT(r=-0.647, P=0.011; r=-0.337, P=0.032).CONCLUSION: The PhNR amplitude of mf-ERG in DME patients increased significantly after receiving aflibercept, and it can be used to observe and evaluate the functional changes of retinal ganglion cells in DME patients. |
| first_indexed | 2024-03-11T16:31:27Z |
| format | Article |
| id | doaj.art-b2a01fd84c764bc0a428e8ff2423fcc6 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-03-11T16:31:27Z |
| publishDate | 2023-11-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
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| series | Guoji Yanke Zazhi |
| spelling | doaj.art-b2a01fd84c764bc0a428e8ff2423fcc62023-10-24T02:34:27ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232023-11-0123111911191410.3980/j.issn.1672-5123.2023.11.28202311028Changes of photopic negative response of multifocal electroretinogram after treatment with Aflibercept in patients with diabetic macular edemaChong Xu0Chao Feng1Jian-Hua Wu2Aier Eye Hospital of Wuhan University;Wuhan Aier Eye Hospital, Wuhan 430064, Hubei Province, ChinaAier Eye Hospital of Wuhan University;Wuhan Aier Eye Hospital, Wuhan 430064, Hubei Province, ChinaAier Eye Hospital of Wuhan University;Wuhan Aier Eye Hospital, Wuhan 430064, Hubei Province, ChinaAIM:To observe the changes of photopic negative response(PhNR)of multifocal electroretinogram(mf-ERG)in patients with diabetic macular edema(DME)before and after treatment with Aflibercept.METHODS: A total of 37 patients(37 eyes)with DME who visited the Aier Eye Hospital of Wuhan University(Wuhan Aier Eye Hospital)from May 2019 to June 2022, and 0.05 mL of aflibercept was injected per month for consecutive 3mo were included in this retrospective cohort study. Another 20 cases(20 eyes)with normal physical examination to exclude related eye diseases were selected as the control group. The PhNR amplitude of mf-ERG, best-corrected visual acuity(BCVA; LogMAR), central retinal thickness(CRT), capillary plexus in macular area and vessel density(CPVD)of the participants between the two groups were compared before and after treatment.RESULTS: The PhNR amplitude of mf-ERG in DME patients before treatment(201.69±80.92nV)was significantly lower than that in the normal control group(398.87±77.92nV; P<0.01), and the average PhNR amplitude of mf-ERG in DME patients at 6mo after treatment was significantly higher than that before treatment(P=0.036), but it was still significantly lower than the normal control group at 6mo after treatment(P=0.031). In addition, the BCVA(LogMAR)of DME patients increased from 0.64±1.33 to 0.37±1.39(P=0.021)at 6mo after treatment, and CPVD significantly increased compared to that before treatment(P=0.029). Meanwhile, the PhNR amplitude of mf-ERG in DME patients at 6mo after treatment was positively correlated with CPVD at 6mo after treatment(r=0.448, P=0.043), and negatively correlated with BCVA(LogMAR)and CRT(r=-0.647, P=0.011; r=-0.337, P=0.032).CONCLUSION: The PhNR amplitude of mf-ERG in DME patients increased significantly after receiving aflibercept, and it can be used to observe and evaluate the functional changes of retinal ganglion cells in DME patients.http://ies.ijo.cn/cn_publish/2023/11/202311028.pdfphotopic negative responsemultifocal electroretinogramdiabetic macular edema |
| spellingShingle | Chong Xu Chao Feng Jian-Hua Wu Changes of photopic negative response of multifocal electroretinogram after treatment with Aflibercept in patients with diabetic macular edema Guoji Yanke Zazhi photopic negative response multifocal electroretinogram diabetic macular edema |
| title | Changes of photopic negative response of multifocal electroretinogram after treatment with Aflibercept in patients with diabetic macular edema |
| title_full | Changes of photopic negative response of multifocal electroretinogram after treatment with Aflibercept in patients with diabetic macular edema |
| title_fullStr | Changes of photopic negative response of multifocal electroretinogram after treatment with Aflibercept in patients with diabetic macular edema |
| title_full_unstemmed | Changes of photopic negative response of multifocal electroretinogram after treatment with Aflibercept in patients with diabetic macular edema |
| title_short | Changes of photopic negative response of multifocal electroretinogram after treatment with Aflibercept in patients with diabetic macular edema |
| title_sort | changes of photopic negative response of multifocal electroretinogram after treatment with aflibercept in patients with diabetic macular edema |
| topic | photopic negative response multifocal electroretinogram diabetic macular edema |
| url | http://ies.ijo.cn/cn_publish/2023/11/202311028.pdf |
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