Advancing Diabetic Retinopathy Research: Analysis of the Neurovascular Unit in Zebrafish
Diabetic retinopathy is one of the most important microvascular complications associated with diabetes mellitus, and a leading cause of vision loss or blindness worldwide. Hyperglycaemic conditions disrupt microvascular integrity at the level of the neurovascular unit. In recent years, zebrafish <...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/6/1313 |
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| author | Chiara Simone Middel Hans-Peter Hammes Jens Kroll |
| author_facet | Chiara Simone Middel Hans-Peter Hammes Jens Kroll |
| author_sort | Chiara Simone Middel |
| collection | DOAJ |
| description | Diabetic retinopathy is one of the most important microvascular complications associated with diabetes mellitus, and a leading cause of vision loss or blindness worldwide. Hyperglycaemic conditions disrupt microvascular integrity at the level of the neurovascular unit. In recent years, zebrafish <i>(Danio rerio)</i> have come into focus as a model organism for various metabolic diseases such as diabetes. In both mammals and vertebrates, the anatomy and the function of the retina and the neurovascular unit have been highly conserved. In this review, we focus on the advances that have been made through studying pathologies associated with retinopathy in zebrafish models of diabetes. We discuss the different cell types that form the neurovascular unit, their role in diabetic retinopathy and how to study them in zebrafish. We then present new insights gained through zebrafish studies. The advantages of using zebrafish for diabetic retinopathy are summarised, including the fact that the zebrafish has, so far, provided the only animal model in which hyperglycaemia-induced retinal angiogenesis can be observed. Based on currently available data, we propose potential investigations that could advance the field further. |
| first_indexed | 2024-03-10T11:04:42Z |
| format | Article |
| id | doaj.art-b2a08480de73400882caec53b261b0f4 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T11:04:42Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-b2a08480de73400882caec53b261b0f42023-11-21T21:17:06ZengMDPI AGCells2073-44092021-05-01106131310.3390/cells10061313Advancing Diabetic Retinopathy Research: Analysis of the Neurovascular Unit in ZebrafishChiara Simone Middel0Hans-Peter Hammes1Jens Kroll2Department of Vascular Biology and Tumor Angiogenesis, European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, GermanyFifth Medical Department and European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, GermanyDepartment of Vascular Biology and Tumor Angiogenesis, European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, GermanyDiabetic retinopathy is one of the most important microvascular complications associated with diabetes mellitus, and a leading cause of vision loss or blindness worldwide. Hyperglycaemic conditions disrupt microvascular integrity at the level of the neurovascular unit. In recent years, zebrafish <i>(Danio rerio)</i> have come into focus as a model organism for various metabolic diseases such as diabetes. In both mammals and vertebrates, the anatomy and the function of the retina and the neurovascular unit have been highly conserved. In this review, we focus on the advances that have been made through studying pathologies associated with retinopathy in zebrafish models of diabetes. We discuss the different cell types that form the neurovascular unit, their role in diabetic retinopathy and how to study them in zebrafish. We then present new insights gained through zebrafish studies. The advantages of using zebrafish for diabetic retinopathy are summarised, including the fact that the zebrafish has, so far, provided the only animal model in which hyperglycaemia-induced retinal angiogenesis can be observed. Based on currently available data, we propose potential investigations that could advance the field further.https://www.mdpi.com/2073-4409/10/6/1313diabetic retinopathyzebrafishneurovascular unitmicrovascular complications and dysfunctionmetabolism |
| spellingShingle | Chiara Simone Middel Hans-Peter Hammes Jens Kroll Advancing Diabetic Retinopathy Research: Analysis of the Neurovascular Unit in Zebrafish Cells diabetic retinopathy zebrafish neurovascular unit microvascular complications and dysfunction metabolism |
| title | Advancing Diabetic Retinopathy Research: Analysis of the Neurovascular Unit in Zebrafish |
| title_full | Advancing Diabetic Retinopathy Research: Analysis of the Neurovascular Unit in Zebrafish |
| title_fullStr | Advancing Diabetic Retinopathy Research: Analysis of the Neurovascular Unit in Zebrafish |
| title_full_unstemmed | Advancing Diabetic Retinopathy Research: Analysis of the Neurovascular Unit in Zebrafish |
| title_short | Advancing Diabetic Retinopathy Research: Analysis of the Neurovascular Unit in Zebrafish |
| title_sort | advancing diabetic retinopathy research analysis of the neurovascular unit in zebrafish |
| topic | diabetic retinopathy zebrafish neurovascular unit microvascular complications and dysfunction metabolism |
| url | https://www.mdpi.com/2073-4409/10/6/1313 |
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