The Histone Acetyltransferase GCN5 and the Associated Coactivators ADA2: From Evolution of the SAGA Complex to the Biological Roles in Plants
Transcription of protein-encoding genes starts with forming a pre-initiation complex comprised of RNA polymerase II and several general transcription factors. To activate gene expression, transcription factors must overcome repressive chromatin structure, which is accomplished with multiprotein comp...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-02-01
|
| Series: | Plants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2223-7747/10/2/308 |
| _version_ | 1797414062253932544 |
|---|---|
| author | Konstantinos Vlachonasios Stylianos Poulios Niki Mougiou |
| author_facet | Konstantinos Vlachonasios Stylianos Poulios Niki Mougiou |
| author_sort | Konstantinos Vlachonasios |
| collection | DOAJ |
| description | Transcription of protein-encoding genes starts with forming a pre-initiation complex comprised of RNA polymerase II and several general transcription factors. To activate gene expression, transcription factors must overcome repressive chromatin structure, which is accomplished with multiprotein complexes. One such complex, SAGA, modifies the nucleosomal histones through acetylation and other histone modifications. A prototypical histone acetyltransferase (HAT) known as general control non-repressed protein 5 (GCN5), was defined biochemically as the first transcription-linked HAT with specificity for histone H3 lysine 14. In this review, we analyze the components of the putative plant SAGA complex during plant evolution, and current knowledge on the biological role of the key components of the HAT module, GCN5 and ADA2b in plants, will be summarized. |
| first_indexed | 2024-03-09T05:26:34Z |
| format | Article |
| id | doaj.art-b2a18960e3e045a583d237c412b32709 |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-09T05:26:34Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-b2a18960e3e045a583d237c412b327092023-12-03T12:36:17ZengMDPI AGPlants2223-77472021-02-0110230810.3390/plants10020308The Histone Acetyltransferase GCN5 and the Associated Coactivators ADA2: From Evolution of the SAGA Complex to the Biological Roles in PlantsKonstantinos Vlachonasios0Stylianos Poulios1Niki Mougiou2Department of Botany, School of Biology, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceDepartment of Botany, School of Biology, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceDepartment of Botany, School of Biology, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceTranscription of protein-encoding genes starts with forming a pre-initiation complex comprised of RNA polymerase II and several general transcription factors. To activate gene expression, transcription factors must overcome repressive chromatin structure, which is accomplished with multiprotein complexes. One such complex, SAGA, modifies the nucleosomal histones through acetylation and other histone modifications. A prototypical histone acetyltransferase (HAT) known as general control non-repressed protein 5 (GCN5), was defined biochemically as the first transcription-linked HAT with specificity for histone H3 lysine 14. In this review, we analyze the components of the putative plant SAGA complex during plant evolution, and current knowledge on the biological role of the key components of the HAT module, GCN5 and ADA2b in plants, will be summarized.https://www.mdpi.com/2223-7747/10/2/308<i>Arabidopsis thaliana</i>ViridiplantaeGCN5ADA2bSGF29ADA3 |
| spellingShingle | Konstantinos Vlachonasios Stylianos Poulios Niki Mougiou The Histone Acetyltransferase GCN5 and the Associated Coactivators ADA2: From Evolution of the SAGA Complex to the Biological Roles in Plants Plants <i>Arabidopsis thaliana</i> Viridiplantae GCN5 ADA2b SGF29 ADA3 |
| title | The Histone Acetyltransferase GCN5 and the Associated Coactivators ADA2: From Evolution of the SAGA Complex to the Biological Roles in Plants |
| title_full | The Histone Acetyltransferase GCN5 and the Associated Coactivators ADA2: From Evolution of the SAGA Complex to the Biological Roles in Plants |
| title_fullStr | The Histone Acetyltransferase GCN5 and the Associated Coactivators ADA2: From Evolution of the SAGA Complex to the Biological Roles in Plants |
| title_full_unstemmed | The Histone Acetyltransferase GCN5 and the Associated Coactivators ADA2: From Evolution of the SAGA Complex to the Biological Roles in Plants |
| title_short | The Histone Acetyltransferase GCN5 and the Associated Coactivators ADA2: From Evolution of the SAGA Complex to the Biological Roles in Plants |
| title_sort | histone acetyltransferase gcn5 and the associated coactivators ada2 from evolution of the saga complex to the biological roles in plants |
| topic | <i>Arabidopsis thaliana</i> Viridiplantae GCN5 ADA2b SGF29 ADA3 |
| url | https://www.mdpi.com/2223-7747/10/2/308 |
| work_keys_str_mv | AT konstantinosvlachonasios thehistoneacetyltransferasegcn5andtheassociatedcoactivatorsada2fromevolutionofthesagacomplextothebiologicalrolesinplants AT stylianospoulios thehistoneacetyltransferasegcn5andtheassociatedcoactivatorsada2fromevolutionofthesagacomplextothebiologicalrolesinplants AT nikimougiou thehistoneacetyltransferasegcn5andtheassociatedcoactivatorsada2fromevolutionofthesagacomplextothebiologicalrolesinplants AT konstantinosvlachonasios histoneacetyltransferasegcn5andtheassociatedcoactivatorsada2fromevolutionofthesagacomplextothebiologicalrolesinplants AT stylianospoulios histoneacetyltransferasegcn5andtheassociatedcoactivatorsada2fromevolutionofthesagacomplextothebiologicalrolesinplants AT nikimougiou histoneacetyltransferasegcn5andtheassociatedcoactivatorsada2fromevolutionofthesagacomplextothebiologicalrolesinplants |