Computational Nanotoxicology Models for Environmental Risk Assessment of Engineered Nanomaterials
Although engineered nanomaterials (ENMs) have tremendous potential to generate technological benefits in numerous sectors, uncertainty on the risks of ENMs for human health and the environment may impede the advancement of novel materials. Traditionally, the risks of ENMs can be evaluated by experim...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/14/2/155 |
| _version_ | 1797342883793076224 |
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| author | Weihao Tang Xuejiao Zhang Huixiao Hong Jingwen Chen Qing Zhao Fengchang Wu |
| author_facet | Weihao Tang Xuejiao Zhang Huixiao Hong Jingwen Chen Qing Zhao Fengchang Wu |
| author_sort | Weihao Tang |
| collection | DOAJ |
| description | Although engineered nanomaterials (ENMs) have tremendous potential to generate technological benefits in numerous sectors, uncertainty on the risks of ENMs for human health and the environment may impede the advancement of novel materials. Traditionally, the risks of ENMs can be evaluated by experimental methods such as environmental field monitoring and animal-based toxicity testing. However, it is time-consuming, expensive, and impractical to evaluate the risk of the increasingly large number of ENMs with the experimental methods. On the contrary, with the advancement of artificial intelligence and machine learning, in silico methods have recently received more attention in the risk assessment of ENMs. This review discusses the key progress of computational nanotoxicology models for assessing the risks of ENMs, including material flow analysis models, multimedia environmental models, physiologically based toxicokinetics models, quantitative nanostructure–activity relationships, and meta-analysis. Several challenges are identified and a perspective is provided regarding how the challenges can be addressed. |
| first_indexed | 2024-03-08T10:39:38Z |
| format | Article |
| id | doaj.art-b2a196bf1ad942ee8dbf258ae0976c08 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-08T10:39:38Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-b2a196bf1ad942ee8dbf258ae0976c082024-01-26T17:58:17ZengMDPI AGNanomaterials2079-49912024-01-0114215510.3390/nano14020155Computational Nanotoxicology Models for Environmental Risk Assessment of Engineered NanomaterialsWeihao Tang0Xuejiao Zhang1Huixiao Hong2Jingwen Chen3Qing Zhao4Fengchang Wu5National-Regional Joint Engineering Research Center for Soil Pollution Control and Remediation in South China, Guangdong Key Laboratory of Integrated Agro-Environmental Pollution Control and Management, Institute of Eco-Environmental and Soil Sciences, Guangdong Academy of Sciences, Guangzhou 510650, ChinaNational-Regional Joint Engineering Research Center for Soil Pollution Control and Remediation in South China, Guangdong Key Laboratory of Integrated Agro-Environmental Pollution Control and Management, Institute of Eco-Environmental and Soil Sciences, Guangdong Academy of Sciences, Guangzhou 510650, ChinaNational Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079, USAKey Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), Dalian Key Laboratory on Chemicals Risk Control and Pollution Prevention Technology, School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, ChinaNational-Regional Joint Engineering Research Center for Soil Pollution Control and Remediation in South China, Guangdong Key Laboratory of Integrated Agro-Environmental Pollution Control and Management, Institute of Eco-Environmental and Soil Sciences, Guangdong Academy of Sciences, Guangzhou 510650, ChinaState Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, ChinaAlthough engineered nanomaterials (ENMs) have tremendous potential to generate technological benefits in numerous sectors, uncertainty on the risks of ENMs for human health and the environment may impede the advancement of novel materials. Traditionally, the risks of ENMs can be evaluated by experimental methods such as environmental field monitoring and animal-based toxicity testing. However, it is time-consuming, expensive, and impractical to evaluate the risk of the increasingly large number of ENMs with the experimental methods. On the contrary, with the advancement of artificial intelligence and machine learning, in silico methods have recently received more attention in the risk assessment of ENMs. This review discusses the key progress of computational nanotoxicology models for assessing the risks of ENMs, including material flow analysis models, multimedia environmental models, physiologically based toxicokinetics models, quantitative nanostructure–activity relationships, and meta-analysis. Several challenges are identified and a perspective is provided regarding how the challenges can be addressed.https://www.mdpi.com/2079-4991/14/2/155engineered nanomaterialscomputational nanotoxicologyexposure modelshazard models |
| spellingShingle | Weihao Tang Xuejiao Zhang Huixiao Hong Jingwen Chen Qing Zhao Fengchang Wu Computational Nanotoxicology Models for Environmental Risk Assessment of Engineered Nanomaterials Nanomaterials engineered nanomaterials computational nanotoxicology exposure models hazard models |
| title | Computational Nanotoxicology Models for Environmental Risk Assessment of Engineered Nanomaterials |
| title_full | Computational Nanotoxicology Models for Environmental Risk Assessment of Engineered Nanomaterials |
| title_fullStr | Computational Nanotoxicology Models for Environmental Risk Assessment of Engineered Nanomaterials |
| title_full_unstemmed | Computational Nanotoxicology Models for Environmental Risk Assessment of Engineered Nanomaterials |
| title_short | Computational Nanotoxicology Models for Environmental Risk Assessment of Engineered Nanomaterials |
| title_sort | computational nanotoxicology models for environmental risk assessment of engineered nanomaterials |
| topic | engineered nanomaterials computational nanotoxicology exposure models hazard models |
| url | https://www.mdpi.com/2079-4991/14/2/155 |
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