Rosiglitazone increases endothelial cell migration and vascular permeability through Akt phosphorylation

Rosiglitazone increases endothelial cell migration and vascular permeability through Akt phosphorylation

Abstract Background Thiazolidinediones (TZDs), peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists, exhibit anti-inflammatory and antioxidant properties and inhibit endothelial inflammation and dysfunction, which is anti-atherogenic. However, fluid retention, which may lead to congestive...

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Bibliographic Details
Main Authors: Yun Hyi Ku, Bong-Jun Cho, Min Joo Kim, Soo Lim, Young Joo Park, Hak C. Jang, Sung Hee Choi
Format: Article
Language:English
Published: BMC 2017-08-01
Series:BMC Pharmacology and Toxicology
Subjects:
Thiazolidinediones
Rosiglitazone
Endothelial cells
Vascular permeability
Edema
Akt
Online Access:http://link.springer.com/article/10.1186/s40360-017-0169-y

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