Application of toxicology data reliability assessment method, a toxicological data reliability evaluation tool, in the neurotoxic hazard assessment of glutamate acid and its salts
Objective This paper aims to evaluate data reliability of the neurotoxic hazard assessment of glutamate and its salts and provide recommendations, as well as to improve toxicology data reliability assessment method (TRAM) via trial application. Methods TRAM was used to evaluate the reliability of 60...
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| Format: | Article |
| Language: | zho |
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The Editorial Office of Chinese Journal of Food Hygiene
2020-09-01
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| Series: | Zhongguo shipin weisheng zazhi |
| Subjects: | |
| Online Access: | http://www.zgspws.com/zgspwszzen/article/abstract/20200508 |
| _version_ | 1797769053629054976 |
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| author | Jie LIANG Ping YU Wenjing XIE Zhongming LYU Yonglin ZHOU Qian BIAN |
| author_facet | Jie LIANG Ping YU Wenjing XIE Zhongming LYU Yonglin ZHOU Qian BIAN |
| author_sort | Jie LIANG |
| collection | DOAJ |
| description | Objective This paper aims to evaluate data reliability of the neurotoxic hazard assessment of glutamate and its salts and provide recommendations, as well as to improve toxicology data reliability assessment method (TRAM) via trial application. Methods TRAM was used to evaluate the reliability of 60 articles which were selected by the method of systematic review documentation retrieval. The evaluation was based on types of toxicological data involved in each paper (laboratory animal data or human data) and they were scored by reliability criteria. The quality percentage was obtained via calculations to judge reliability categories and give recommendations. It’s necessary to note that the evaluation of each paper was independently completed by two persons in related fields. Results After three rounds of evaluation, the reliability of 12 articles were evaluated as "high" and recommended for priority use. The reliability of 43 articles was rated as "moderate" and can be used. The reliability of 5 articles was evaluated as "low" and not recommended to use. Conclusion TRAM takes both reporting quality and methodological quality into consideration, especially including human data reliability evaluation method which is absent in the other toxicology data reliability assessment tools. TRAM is more suitable for food safety risk assessment. It provides a better objective and scientific guarantee for hazard identification and risk assessment. |
| first_indexed | 2024-03-12T21:03:17Z |
| format | Article |
| id | doaj.art-b2a3d8c8e1904521a30423f1f6b4d207 |
| institution | Directory Open Access Journal |
| issn | 1004-8456 |
| language | zho |
| last_indexed | 2024-03-12T21:03:17Z |
| publishDate | 2020-09-01 |
| publisher | The Editorial Office of Chinese Journal of Food Hygiene |
| record_format | Article |
| series | Zhongguo shipin weisheng zazhi |
| spelling | doaj.art-b2a3d8c8e1904521a30423f1f6b4d2072023-07-31T02:32:01ZzhoThe Editorial Office of Chinese Journal of Food HygieneZhongguo shipin weisheng zazhi1004-84562020-09-01320550951310.13590/j.cjfh.2020.05.0071004-8456(2020)05-0509-05Application of toxicology data reliability assessment method, a toxicological data reliability evaluation tool, in the neurotoxic hazard assessment of glutamate acid and its saltsJie LIANG0Ping YU1Wenjing XIE2Zhongming LYU3Yonglin ZHOU4Qian BIAN5School of Public Health, Nanjing Medical University, Jiangsu Nanjing 211166, ChinaCenter for Disease Control and Prevention of Jiangsu Province, Jiangsu Nanjing 210009, ChinaSchool of Public Health, Southeast University, Jiangsu Nanjing 210009, ChinaCenter for Disease Control and Prevention of Jiangsu Province, Jiangsu Nanjing 210009, ChinaCenter for Disease Control and Prevention of Jiangsu Province, Jiangsu Nanjing 210009, ChinaSchool of Public Health, Nanjing Medical University, Jiangsu Nanjing 211166, ChinaObjective This paper aims to evaluate data reliability of the neurotoxic hazard assessment of glutamate and its salts and provide recommendations, as well as to improve toxicology data reliability assessment method (TRAM) via trial application. Methods TRAM was used to evaluate the reliability of 60 articles which were selected by the method of systematic review documentation retrieval. The evaluation was based on types of toxicological data involved in each paper (laboratory animal data or human data) and they were scored by reliability criteria. The quality percentage was obtained via calculations to judge reliability categories and give recommendations. It’s necessary to note that the evaluation of each paper was independently completed by two persons in related fields. Results After three rounds of evaluation, the reliability of 12 articles were evaluated as "high" and recommended for priority use. The reliability of 43 articles was rated as "moderate" and can be used. The reliability of 5 articles was evaluated as "low" and not recommended to use. Conclusion TRAM takes both reporting quality and methodological quality into consideration, especially including human data reliability evaluation method which is absent in the other toxicology data reliability assessment tools. TRAM is more suitable for food safety risk assessment. It provides a better objective and scientific guarantee for hazard identification and risk assessment.http://www.zgspws.com/zgspwszzen/article/abstract/20200508toxicological datareliabilitytoxicology data reliability assessment methodglutamatehazard assessment |
| spellingShingle | Jie LIANG Ping YU Wenjing XIE Zhongming LYU Yonglin ZHOU Qian BIAN Application of toxicology data reliability assessment method, a toxicological data reliability evaluation tool, in the neurotoxic hazard assessment of glutamate acid and its salts Zhongguo shipin weisheng zazhi toxicological data reliability toxicology data reliability assessment method glutamate hazard assessment |
| title | Application of toxicology data reliability assessment method, a toxicological data reliability evaluation tool, in the neurotoxic hazard assessment of glutamate acid and its salts |
| title_full | Application of toxicology data reliability assessment method, a toxicological data reliability evaluation tool, in the neurotoxic hazard assessment of glutamate acid and its salts |
| title_fullStr | Application of toxicology data reliability assessment method, a toxicological data reliability evaluation tool, in the neurotoxic hazard assessment of glutamate acid and its salts |
| title_full_unstemmed | Application of toxicology data reliability assessment method, a toxicological data reliability evaluation tool, in the neurotoxic hazard assessment of glutamate acid and its salts |
| title_short | Application of toxicology data reliability assessment method, a toxicological data reliability evaluation tool, in the neurotoxic hazard assessment of glutamate acid and its salts |
| title_sort | application of toxicology data reliability assessment method a toxicological data reliability evaluation tool in the neurotoxic hazard assessment of glutamate acid and its salts |
| topic | toxicological data reliability toxicology data reliability assessment method glutamate hazard assessment |
| url | http://www.zgspws.com/zgspwszzen/article/abstract/20200508 |
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