Polycyclic Aromatic Hydrocarbons Affect Rheumatoid Arthritis Pathogenesis via Aryl Hydrocarbon Receptor
Rheumatoid arthritis (RA), the most common autoimmune disease, is characterized by symmetrical synovial inflammation of multiple joints with the infiltration of pro-inflammatory immune cells and increased cytokines (CKs) levels. In the past few years, numerous studies have indicated that several fac...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.797815/full |
| _version_ | 1828875328310738944 |
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| author | Xiaoyu Xi Xiaoyu Xi Qinbin Ye Qinbin Ye Danping Fan Danping Fan Xiaoxue Cao Xiaoxue Cao Qiong Wang Qiong Wang Xing Wang Xing Wang Mengxiao Zhang Yuan Xu Cheng Xiao Cheng Xiao |
| author_facet | Xiaoyu Xi Xiaoyu Xi Qinbin Ye Qinbin Ye Danping Fan Danping Fan Xiaoxue Cao Xiaoxue Cao Qiong Wang Qiong Wang Xing Wang Xing Wang Mengxiao Zhang Yuan Xu Cheng Xiao Cheng Xiao |
| author_sort | Xiaoyu Xi |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA), the most common autoimmune disease, is characterized by symmetrical synovial inflammation of multiple joints with the infiltration of pro-inflammatory immune cells and increased cytokines (CKs) levels. In the past few years, numerous studies have indicated that several factors could affect RA, such as mutations in susceptibility genes, epigenetic modifications, age, and race. Recently, environmental factors, particularly polycyclic aromatic hydrocarbons (PAHs), have attracted increasing attention in RA pathogenesis. Therefore, exploring the specific mechanisms of PAHs in RA is vitally critical. In this review, we summarize the recent progress in understanding the mechanisms of PAHs and aryl hydrocarbon receptors (AHRs) in RA. Additionally, the development of therapeutic drugs that target AHR is also reviewed. Finally, we discuss the challenges and perspectives on AHR application in the future. |
| first_indexed | 2024-12-13T07:57:00Z |
| format | Article |
| id | doaj.art-b2a4c78936704b6cbfcf1f23bd0d06d1 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-13T07:57:00Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b2a4c78936704b6cbfcf1f23bd0d06d12022-12-21T23:54:31ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-03-011310.3389/fimmu.2022.797815797815Polycyclic Aromatic Hydrocarbons Affect Rheumatoid Arthritis Pathogenesis via Aryl Hydrocarbon ReceptorXiaoyu Xi0Xiaoyu Xi1Qinbin Ye2Qinbin Ye3Danping Fan4Danping Fan5Xiaoxue Cao6Xiaoxue Cao7Qiong Wang8Qiong Wang9Xing Wang10Xing Wang11Mengxiao Zhang12Yuan Xu13Cheng Xiao14Cheng Xiao15School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaInstitute of Clinical Medicine, China-Japan Friendship Hospital, Beijing, ChinaSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaInstitute of Clinical Medicine, China-Japan Friendship Hospital, Beijing, ChinaInstitute of Clinical Medicine, China-Japan Friendship Hospital, Beijing, ChinaGraduate School of Peking Union Medical College, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, ChinaInstitute of Clinical Medicine, China-Japan Friendship Hospital, Beijing, ChinaGraduate School of Peking Union Medical College, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, ChinaSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaInstitute of Clinical Medicine, China-Japan Friendship Hospital, Beijing, ChinaSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaInstitute of Clinical Medicine, China-Japan Friendship Hospital, Beijing, ChinaInstitute of Clinical Medicine, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Traditional Chinese Medicine (TCM) Rheumatology, China-Japan Friendship Hospital, Beijing, ChinaInstitute of Clinical Medicine, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Emergency, China-Japan Friendship Hospital, Beijing, ChinaRheumatoid arthritis (RA), the most common autoimmune disease, is characterized by symmetrical synovial inflammation of multiple joints with the infiltration of pro-inflammatory immune cells and increased cytokines (CKs) levels. In the past few years, numerous studies have indicated that several factors could affect RA, such as mutations in susceptibility genes, epigenetic modifications, age, and race. Recently, environmental factors, particularly polycyclic aromatic hydrocarbons (PAHs), have attracted increasing attention in RA pathogenesis. Therefore, exploring the specific mechanisms of PAHs in RA is vitally critical. In this review, we summarize the recent progress in understanding the mechanisms of PAHs and aryl hydrocarbon receptors (AHRs) in RA. Additionally, the development of therapeutic drugs that target AHR is also reviewed. Finally, we discuss the challenges and perspectives on AHR application in the future.https://www.frontiersin.org/articles/10.3389/fimmu.2022.797815/fullrheumatoid arthritispolycyclic aromatic hydrocarbonsparticulate matteraryl hydrocarbon receptoraryl hydrocarbon receptor repressor |
| spellingShingle | Xiaoyu Xi Xiaoyu Xi Qinbin Ye Qinbin Ye Danping Fan Danping Fan Xiaoxue Cao Xiaoxue Cao Qiong Wang Qiong Wang Xing Wang Xing Wang Mengxiao Zhang Yuan Xu Cheng Xiao Cheng Xiao Polycyclic Aromatic Hydrocarbons Affect Rheumatoid Arthritis Pathogenesis via Aryl Hydrocarbon Receptor Frontiers in Immunology rheumatoid arthritis polycyclic aromatic hydrocarbons particulate matter aryl hydrocarbon receptor aryl hydrocarbon receptor repressor |
| title | Polycyclic Aromatic Hydrocarbons Affect Rheumatoid Arthritis Pathogenesis via Aryl Hydrocarbon Receptor |
| title_full | Polycyclic Aromatic Hydrocarbons Affect Rheumatoid Arthritis Pathogenesis via Aryl Hydrocarbon Receptor |
| title_fullStr | Polycyclic Aromatic Hydrocarbons Affect Rheumatoid Arthritis Pathogenesis via Aryl Hydrocarbon Receptor |
| title_full_unstemmed | Polycyclic Aromatic Hydrocarbons Affect Rheumatoid Arthritis Pathogenesis via Aryl Hydrocarbon Receptor |
| title_short | Polycyclic Aromatic Hydrocarbons Affect Rheumatoid Arthritis Pathogenesis via Aryl Hydrocarbon Receptor |
| title_sort | polycyclic aromatic hydrocarbons affect rheumatoid arthritis pathogenesis via aryl hydrocarbon receptor |
| topic | rheumatoid arthritis polycyclic aromatic hydrocarbons particulate matter aryl hydrocarbon receptor aryl hydrocarbon receptor repressor |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.797815/full |
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