Effect of pulmonary hypertension on outcome of pulmonary tuberculosis
Background: This study performed at the National Research Institute of Tuberculosis and Lung Disease, Tehran, Iran, aimed to evaluate the effect of concomitant pulmonary hypertension on the outcome of pulmonary tuberculosis. Methods: New cases of pulmonary tuberculosis were recruited for the study....
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2014-09-01
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| Series: | Brazilian Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1413867014000713 |
| _version_ | 1818477191961247744 |
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| author | Majid Marjani Parvaneh Baghaei Majid Malekmohammad Payam Tabarsi Babak Sharif-Kashani Neda Behzadnia Davood Mansouri Mohammad Reza Masjedi Ali Akbar Velayati |
| author_facet | Majid Marjani Parvaneh Baghaei Majid Malekmohammad Payam Tabarsi Babak Sharif-Kashani Neda Behzadnia Davood Mansouri Mohammad Reza Masjedi Ali Akbar Velayati |
| author_sort | Majid Marjani |
| collection | DOAJ |
| description | Background: This study performed at the National Research Institute of Tuberculosis and Lung Disease, Tehran, Iran, aimed to evaluate the effect of concomitant pulmonary hypertension on the outcome of pulmonary tuberculosis. Methods: New cases of pulmonary tuberculosis were recruited for the study. Pulmonary hypertension was defined as systolic pulmonary arterial pressure ≥35 mm Hg estimated by transthoracic Doppler echocardiography. We assessed the relationship between pulmonary hypertension and mortality during the six-month treatment of tuberculosis. Results: Of 777 new cases of pulmonary tuberculosis, 74 (9.5%) had systolic pulmonary arterial pressure ≥35 mm Hg. Ten of them (13.5%) died during treatment compared to 5% of cases with pulmonary arterial pressure less than 35 mm Hg (p = 0.007). Logistic regression analysis showed that pulmonary hypertension and drug abuse remained independently associated with mortality (OR = 3.1; 95% CI: 1.44–6.75 and OR = 4.4; 95% CI: 2.35–8.17, respectively). Conclusion: A significant association was found between mortality and presence of pulmonary hypertension and drug abuse among new cases of pulmonary tuberculosis. Keywords: Tuberculosis, Pulmonary hypertension, Echocardiography, Survival |
| first_indexed | 2024-12-10T09:35:00Z |
| format | Article |
| id | doaj.art-b2a4d3891b2a4839a19b7b931c2a89e9 |
| institution | Directory Open Access Journal |
| issn | 1413-8670 |
| language | English |
| last_indexed | 2024-12-10T09:35:00Z |
| publishDate | 2014-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-b2a4d3891b2a4839a19b7b931c2a89e92022-12-22T01:54:12ZengElsevierBrazilian Journal of Infectious Diseases1413-86702014-09-01185487490S1413-86702014000500487Effect of pulmonary hypertension on outcome of pulmonary tuberculosisMajid Marjani0Parvaneh Baghaei1Majid Malekmohammad2Payam Tabarsi3Babak Sharif-Kashani4Neda Behzadnia5Davood Mansouri6Mohammad Reza Masjedi7Ali Akbar Velayati8Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranClinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran; Corresponding author.Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranMycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTobacco Prevention and Control Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranLung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranClinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTelemedicine Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranClinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranBackground: This study performed at the National Research Institute of Tuberculosis and Lung Disease, Tehran, Iran, aimed to evaluate the effect of concomitant pulmonary hypertension on the outcome of pulmonary tuberculosis. Methods: New cases of pulmonary tuberculosis were recruited for the study. Pulmonary hypertension was defined as systolic pulmonary arterial pressure ≥35 mm Hg estimated by transthoracic Doppler echocardiography. We assessed the relationship between pulmonary hypertension and mortality during the six-month treatment of tuberculosis. Results: Of 777 new cases of pulmonary tuberculosis, 74 (9.5%) had systolic pulmonary arterial pressure ≥35 mm Hg. Ten of them (13.5%) died during treatment compared to 5% of cases with pulmonary arterial pressure less than 35 mm Hg (p = 0.007). Logistic regression analysis showed that pulmonary hypertension and drug abuse remained independently associated with mortality (OR = 3.1; 95% CI: 1.44–6.75 and OR = 4.4; 95% CI: 2.35–8.17, respectively). Conclusion: A significant association was found between mortality and presence of pulmonary hypertension and drug abuse among new cases of pulmonary tuberculosis. Keywords: Tuberculosis, Pulmonary hypertension, Echocardiography, Survivalhttp://www.sciencedirect.com/science/article/pii/S1413867014000713 |
| spellingShingle | Majid Marjani Parvaneh Baghaei Majid Malekmohammad Payam Tabarsi Babak Sharif-Kashani Neda Behzadnia Davood Mansouri Mohammad Reza Masjedi Ali Akbar Velayati Effect of pulmonary hypertension on outcome of pulmonary tuberculosis Brazilian Journal of Infectious Diseases |
| title | Effect of pulmonary hypertension on outcome of pulmonary tuberculosis |
| title_full | Effect of pulmonary hypertension on outcome of pulmonary tuberculosis |
| title_fullStr | Effect of pulmonary hypertension on outcome of pulmonary tuberculosis |
| title_full_unstemmed | Effect of pulmonary hypertension on outcome of pulmonary tuberculosis |
| title_short | Effect of pulmonary hypertension on outcome of pulmonary tuberculosis |
| title_sort | effect of pulmonary hypertension on outcome of pulmonary tuberculosis |
| url | http://www.sciencedirect.com/science/article/pii/S1413867014000713 |
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