Potential of Cyanine Derived Dyes in Photodynamic Therapy
Photodynamic therapy (PDT) is a method of cancer treatment that leads to the disintegration of cancer cells and has developed significantly in recent years. The clinically used photosensitizers are primarily porphyrin, which absorbs light in the red spectrum and their absorbance maxima are relativel...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/6/818 |
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| author | Natalia Lange Wojciech Szlasa Jolanta Saczko Agnieszka Chwiłkowska |
| author_facet | Natalia Lange Wojciech Szlasa Jolanta Saczko Agnieszka Chwiłkowska |
| author_sort | Natalia Lange |
| collection | DOAJ |
| description | Photodynamic therapy (PDT) is a method of cancer treatment that leads to the disintegration of cancer cells and has developed significantly in recent years. The clinically used photosensitizers are primarily porphyrin, which absorbs light in the red spectrum and their absorbance maxima are relatively short. This review presents group of compounds and their derivatives that are considered to be potential photosensitizers in PDT. Cyanine dyes are compounds that typically absorb light in the visible to near-infrared-I (NIR-I) spectrum range (750–900 nm). This meta-analysis comprises the current studies on cyanine dye derivatives, such as indocyanine green (so far used solely as a diagnostic agent), heptamethine and pentamethine dyes, squaraine dyes, merocyanines and phthalocyanines. The wide array of the cyanine derivatives arises from their structural modifications (e.g., halogenation, incorporation of metal atoms or organic structures, or synthesis of lactosomes, emulsions or conjugation). All the following modifications aim to increase solubility in aqueous media, enhance phototoxicity, and decrease photobleaching. In addition, the changes introduce new features like pH-sensitivity. The cyanine dyes involved in photodynamic reactions could be incorporated into sets of PDT agents. |
| first_indexed | 2024-03-10T10:51:57Z |
| format | Article |
| id | doaj.art-b2a6e8dabd6641a880332a36a24958c4 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T10:51:57Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-b2a6e8dabd6641a880332a36a24958c42023-11-21T22:11:24ZengMDPI AGPharmaceutics1999-49232021-05-0113681810.3390/pharmaceutics13060818Potential of Cyanine Derived Dyes in Photodynamic TherapyNatalia Lange0Wojciech Szlasa1Jolanta Saczko2Agnieszka Chwiłkowska3Faculty of Medicine, Wroclaw Medical University, Mikulicza-Radeckiego 5, 50-345 Wroclaw, PolandFaculty of Medicine, Wroclaw Medical University, Mikulicza-Radeckiego 5, 50-345 Wroclaw, PolandDepartment of Molecular and Cellular Biology, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, PolandDepartment of Molecular and Cellular Biology, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, PolandPhotodynamic therapy (PDT) is a method of cancer treatment that leads to the disintegration of cancer cells and has developed significantly in recent years. The clinically used photosensitizers are primarily porphyrin, which absorbs light in the red spectrum and their absorbance maxima are relatively short. This review presents group of compounds and their derivatives that are considered to be potential photosensitizers in PDT. Cyanine dyes are compounds that typically absorb light in the visible to near-infrared-I (NIR-I) spectrum range (750–900 nm). This meta-analysis comprises the current studies on cyanine dye derivatives, such as indocyanine green (so far used solely as a diagnostic agent), heptamethine and pentamethine dyes, squaraine dyes, merocyanines and phthalocyanines. The wide array of the cyanine derivatives arises from their structural modifications (e.g., halogenation, incorporation of metal atoms or organic structures, or synthesis of lactosomes, emulsions or conjugation). All the following modifications aim to increase solubility in aqueous media, enhance phototoxicity, and decrease photobleaching. In addition, the changes introduce new features like pH-sensitivity. The cyanine dyes involved in photodynamic reactions could be incorporated into sets of PDT agents.https://www.mdpi.com/1999-4923/13/6/818cyanine dyesphotodynamic therapycancer therapyirradiation |
| spellingShingle | Natalia Lange Wojciech Szlasa Jolanta Saczko Agnieszka Chwiłkowska Potential of Cyanine Derived Dyes in Photodynamic Therapy Pharmaceutics cyanine dyes photodynamic therapy cancer therapy irradiation |
| title | Potential of Cyanine Derived Dyes in Photodynamic Therapy |
| title_full | Potential of Cyanine Derived Dyes in Photodynamic Therapy |
| title_fullStr | Potential of Cyanine Derived Dyes in Photodynamic Therapy |
| title_full_unstemmed | Potential of Cyanine Derived Dyes in Photodynamic Therapy |
| title_short | Potential of Cyanine Derived Dyes in Photodynamic Therapy |
| title_sort | potential of cyanine derived dyes in photodynamic therapy |
| topic | cyanine dyes photodynamic therapy cancer therapy irradiation |
| url | https://www.mdpi.com/1999-4923/13/6/818 |
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