Lipid metabolism and tumor immunotherapy
In recent years, the relationship between lipid metabolism and tumour immunotherapy has been thoroughly investigated. An increasing number of studies have shown that abnormal gene expression and ectopic levels of metabolites related to fatty acid synthesis or fatty acid oxidation affect tumour metas...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1187989/full |
| _version_ | 1797344439896637440 |
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| author | Yue Wang Yue Wang Yue Wang Zongjin Guo Adamu Danbala Isah Shuangwei Chen Yongfei Ren Huazhong Cai Huazhong Cai |
| author_facet | Yue Wang Yue Wang Yue Wang Zongjin Guo Adamu Danbala Isah Shuangwei Chen Yongfei Ren Huazhong Cai Huazhong Cai |
| author_sort | Yue Wang |
| collection | DOAJ |
| description | In recent years, the relationship between lipid metabolism and tumour immunotherapy has been thoroughly investigated. An increasing number of studies have shown that abnormal gene expression and ectopic levels of metabolites related to fatty acid synthesis or fatty acid oxidation affect tumour metastasis, recurrence, and drug resistance. Tumour immunotherapy that aims to promote an antitumour immune response has greatly improved the outcomes for tumour patients. However, lipid metabolism reprogramming in tumour cells or tumour microenvironment-infiltrating immune cells can influence the antitumour response of immune cells and induce tumor cell immune evasion. The recent increase in the prevalence of obesity-related cancers has drawn attention to the fact that obesity increases fatty acid oxidation in cancer cells and suppresses the activation of immune cells, thereby weakening antitumour immunity. This article reviews the changes in lipid metabolism in cells in the tumour microenvironment and describes the relationship between lipid metabolism reprogramming in multiple cell types and tumour immunotherapy. |
| first_indexed | 2024-03-08T11:02:28Z |
| format | Article |
| id | doaj.art-b2a88f2082564ac09e4692c1fd0c3052 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-03-08T11:02:28Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-b2a88f2082564ac09e4692c1fd0c30522024-01-26T15:45:47ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-05-011110.3389/fcell.2023.11879891187989Lipid metabolism and tumor immunotherapyYue Wang0Yue Wang1Yue Wang2Zongjin Guo3Adamu Danbala Isah4Shuangwei Chen5Yongfei Ren6Huazhong Cai7Huazhong Cai8School of Medicine, Jiangsu University, Zhenjiang, ChinaCancer Institute of Jiangsu University, Affiliated Hospital of Jiangsu University, Zhenjiang, ChinaDepartment of Emergency, Affiliated Hospital of Jiangsu University, Zhenjiang, ChinaDepartment of Interventional Radiology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, ChinaSchool of Medicine, Jiangsu University, Zhenjiang, ChinaSchool of Medicine, Jiangsu University, Zhenjiang, ChinaSchool of Medicine, Jiangsu University, Zhenjiang, ChinaCancer Institute of Jiangsu University, Affiliated Hospital of Jiangsu University, Zhenjiang, ChinaDepartment of Emergency, Affiliated Hospital of Jiangsu University, Zhenjiang, ChinaIn recent years, the relationship between lipid metabolism and tumour immunotherapy has been thoroughly investigated. An increasing number of studies have shown that abnormal gene expression and ectopic levels of metabolites related to fatty acid synthesis or fatty acid oxidation affect tumour metastasis, recurrence, and drug resistance. Tumour immunotherapy that aims to promote an antitumour immune response has greatly improved the outcomes for tumour patients. However, lipid metabolism reprogramming in tumour cells or tumour microenvironment-infiltrating immune cells can influence the antitumour response of immune cells and induce tumor cell immune evasion. The recent increase in the prevalence of obesity-related cancers has drawn attention to the fact that obesity increases fatty acid oxidation in cancer cells and suppresses the activation of immune cells, thereby weakening antitumour immunity. This article reviews the changes in lipid metabolism in cells in the tumour microenvironment and describes the relationship between lipid metabolism reprogramming in multiple cell types and tumour immunotherapy.https://www.frontiersin.org/articles/10.3389/fcell.2023.1187989/fulllipid metabolismtumor microenvironmentimmunotherapycombination therapyimmune cells |
| spellingShingle | Yue Wang Yue Wang Yue Wang Zongjin Guo Adamu Danbala Isah Shuangwei Chen Yongfei Ren Huazhong Cai Huazhong Cai Lipid metabolism and tumor immunotherapy Frontiers in Cell and Developmental Biology lipid metabolism tumor microenvironment immunotherapy combination therapy immune cells |
| title | Lipid metabolism and tumor immunotherapy |
| title_full | Lipid metabolism and tumor immunotherapy |
| title_fullStr | Lipid metabolism and tumor immunotherapy |
| title_full_unstemmed | Lipid metabolism and tumor immunotherapy |
| title_short | Lipid metabolism and tumor immunotherapy |
| title_sort | lipid metabolism and tumor immunotherapy |
| topic | lipid metabolism tumor microenvironment immunotherapy combination therapy immune cells |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1187989/full |
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