Chronic respiratory disease and coronavirus disease 2019 in developing countries: A systematic review
The proportion of coronavirus disease 2019 (COVID-19) patients having a chronic respiratory disease (CRD), and its impact on COVID-19 related patient outcomes, is unclear. We conducted this systematic review to evaluate the proportion of patients with asthma or chronic obstructive pulmonary disease...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | International Journal of Noncommunicable Diseases |
| Subjects: | |
| Online Access: | http://www.ijncd.org/article.asp?issn=2468-8827;year=2022;volume=7;issue=1;spage=3;epage=12;aulast=Aggarwal |
| _version_ | 1811290098968297472 |
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| author | Ashutosh Nath Aggarwal Ritesh Agarwal Sahajal Dhooria Kuruswamy Thurai Prasad Inderpaul Singh Sehgal Valliappan Muthu |
| author_facet | Ashutosh Nath Aggarwal Ritesh Agarwal Sahajal Dhooria Kuruswamy Thurai Prasad Inderpaul Singh Sehgal Valliappan Muthu |
| author_sort | Ashutosh Nath Aggarwal |
| collection | DOAJ |
| description | The proportion of coronavirus disease 2019 (COVID-19) patients having a chronic respiratory disease (CRD), and its impact on COVID-19 related patient outcomes, is unclear. We conducted this systematic review to evaluate the proportion of patients with asthma or chronic obstructive pulmonary disease (COPD) among COVID-19 patients, and to assess if comorbid CRD worsens COVID-19 outcomes, in developing countries. We queried PubMed database for studies conducted in developing countries and provided data on the proportion of COVID-19 patients with CRD, or severe disease or mortality among COVID-19 patients with and without CRD. We calculated proportion of CRD patients and relative risk (RR) for each reported outcome of interest. We used random-effects models to summarize our data. We retrieved 1947 citations and included 22 studies from developing countries in our review. The pooled estimate for proportion of asthma and COPD was 2.32% (95% confidence interval [CI] 1.86%–2.83%) and 3.52% (95% CI 2.14%–5.20%), respectively. COVID-19 patients with asthma had a higher risk of severe COVID-19 (summary RR 1.21, 95% CI 1.17–1.25), but not of mortality (summary RR 1.01, 95% CI 0.80–1.28), as compared to COVID-19 patients without asthma. COVID-19 patients with COPD had a higher risk of severe COVID-19 (summary RR 1.48, 95% CI 1.30–1.69) and mortality (summary RR 2.69, 95% CI 1.57–4.61), as compared to COVID-19 patients without COPD. Patients with asthma (but not COPD) in developing countries may be less likely to acquire COVID-19. Both diseases may increase the risk of severe COVID-19, and COPD may increase risk of COVID-19-related mortality. |
| first_indexed | 2024-04-13T04:06:51Z |
| format | Article |
| id | doaj.art-b2a95f1176e24b59a55c36c8353b3725 |
| institution | Directory Open Access Journal |
| issn | 2468-8827 2468-8835 |
| language | English |
| last_indexed | 2024-04-13T04:06:51Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Noncommunicable Diseases |
| spelling | doaj.art-b2a95f1176e24b59a55c36c8353b37252022-12-22T03:03:14ZengWolters Kluwer Medknow PublicationsInternational Journal of Noncommunicable Diseases2468-88272468-88352022-01-017131210.4103/jncd.jncd_5_22Chronic respiratory disease and coronavirus disease 2019 in developing countries: A systematic reviewAshutosh Nath AggarwalRitesh AgarwalSahajal DhooriaKuruswamy Thurai PrasadInderpaul Singh SehgalValliappan MuthuThe proportion of coronavirus disease 2019 (COVID-19) patients having a chronic respiratory disease (CRD), and its impact on COVID-19 related patient outcomes, is unclear. We conducted this systematic review to evaluate the proportion of patients with asthma or chronic obstructive pulmonary disease (COPD) among COVID-19 patients, and to assess if comorbid CRD worsens COVID-19 outcomes, in developing countries. We queried PubMed database for studies conducted in developing countries and provided data on the proportion of COVID-19 patients with CRD, or severe disease or mortality among COVID-19 patients with and without CRD. We calculated proportion of CRD patients and relative risk (RR) for each reported outcome of interest. We used random-effects models to summarize our data. We retrieved 1947 citations and included 22 studies from developing countries in our review. The pooled estimate for proportion of asthma and COPD was 2.32% (95% confidence interval [CI] 1.86%–2.83%) and 3.52% (95% CI 2.14%–5.20%), respectively. COVID-19 patients with asthma had a higher risk of severe COVID-19 (summary RR 1.21, 95% CI 1.17–1.25), but not of mortality (summary RR 1.01, 95% CI 0.80–1.28), as compared to COVID-19 patients without asthma. COVID-19 patients with COPD had a higher risk of severe COVID-19 (summary RR 1.48, 95% CI 1.30–1.69) and mortality (summary RR 2.69, 95% CI 1.57–4.61), as compared to COVID-19 patients without COPD. Patients with asthma (but not COPD) in developing countries may be less likely to acquire COVID-19. Both diseases may increase the risk of severe COVID-19, and COPD may increase risk of COVID-19-related mortality.http://www.ijncd.org/article.asp?issn=2468-8827;year=2022;volume=7;issue=1;spage=3;epage=12;aulast=Aggarwalasthmachronic obstructive pulmonary diseasecoronavirus disease 2019outcomessystematic review |
| spellingShingle | Ashutosh Nath Aggarwal Ritesh Agarwal Sahajal Dhooria Kuruswamy Thurai Prasad Inderpaul Singh Sehgal Valliappan Muthu Chronic respiratory disease and coronavirus disease 2019 in developing countries: A systematic review International Journal of Noncommunicable Diseases asthma chronic obstructive pulmonary disease coronavirus disease 2019 outcomes systematic review |
| title | Chronic respiratory disease and coronavirus disease 2019 in developing countries: A systematic review |
| title_full | Chronic respiratory disease and coronavirus disease 2019 in developing countries: A systematic review |
| title_fullStr | Chronic respiratory disease and coronavirus disease 2019 in developing countries: A systematic review |
| title_full_unstemmed | Chronic respiratory disease and coronavirus disease 2019 in developing countries: A systematic review |
| title_short | Chronic respiratory disease and coronavirus disease 2019 in developing countries: A systematic review |
| title_sort | chronic respiratory disease and coronavirus disease 2019 in developing countries a systematic review |
| topic | asthma chronic obstructive pulmonary disease coronavirus disease 2019 outcomes systematic review |
| url | http://www.ijncd.org/article.asp?issn=2468-8827;year=2022;volume=7;issue=1;spage=3;epage=12;aulast=Aggarwal |
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