| Summary: | We studied the influence of rosuvastatin adding to lisinopril/amlodipine or lisinopril/ hydrochlorothiazide fixed combinations on blood pressure (BP) and arterial stiffness dynamics in hypertensive patients of high or very high cardiovascular risk.
Methods: 60 patients (36 men and 24 women aged 52.1 ± 7.3) with uncontrolled high or very high cardiovascular risk hypertension (HTN) were randomized into two groups. Group 1 (n = 30) received a fixed combination of lisinopril/amlodipine 10/5 mg/day. Group 2 consisted of 30 patients who received a fixed combination of lisinopril/hydrochlorothiazide 10-20/12.5 mg/day. The rosuvastatin 20mg/day was added in the both groups. The office BP, central (aortic) BP, augmentation index (AIx), carotid-femoral and carotid-radial pulse wave velocity (PWV) dynamics was evaluated during 24-week follow-up period.
Results: Baseline clinical characteristics did not differ in the groups. The office BP decreased in both groups from 173.3 ± 20.2/104.4 ± 14.0 to 131.2 ± 10.4/83.5 ± 7.8 mmHg (p < 0.001) in the 1-st group and from 168.6 ± 23.6/103.6 ± 15.6 to 135.6 ± 15.1/87.3 ± 11.5 mmHg (p < 0.001) in the 2nd one. The extent of office BP did not differ. Howeverthe degree of central systolic BP reduction was more prominent in the 2nd group (10.5 ± 6,8 and 6.5 ± 7.8 mmHg, respectively). The extent of AIx decline did not differ. Carotid-femoral PWV equally decreased in both groups (from 9.5 ± 1.7 to 8.8 ± 1.8; р = 0.043 and from 8.9 ± 1.2 to 8.1 ± 1.4 m/s; р = 0.001, respectively). Carotid-radial PWV reliably declined only in the 1st group (from 9.5 ± 1.8 to 8.8 ± 1.1 m/s; р = 0.034).
Conclusion: Addition of rosuvastatin to a fixed lisinopril/amlodipine combination has proved to be more effective than lisinopril/hydrochlorothiazide plus rosuvastatin combination in terms of impact on central aortic systolic BP and carotid-radial PWV.
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