Association of small intestinal bacterial overgrowth with nonalcoholic fatty liver disease in children: A meta-analysis.
It has been suggested that small intestinal bacterial overgrowth (SIBO) could cause nonalcoholic fatty liver disease (NAFLD), but this association was not examined in children by meta-analysis. This meta-analysis aimed to determine the association between SIBO and NAFLD in children. The electronic d...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0260479 |
| _version_ | 1818750352961306624 |
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| author | Linghan Kuang Wei Zhou Yongmei Jiang |
| author_facet | Linghan Kuang Wei Zhou Yongmei Jiang |
| author_sort | Linghan Kuang |
| collection | DOAJ |
| description | It has been suggested that small intestinal bacterial overgrowth (SIBO) could cause nonalcoholic fatty liver disease (NAFLD), but this association was not examined in children by meta-analysis. This meta-analysis aimed to determine the association between SIBO and NAFLD in children. The electronic databases PubMed, Embase, and Cochrane Library were searched for studies published before April 22, 2021. The outcome was the association between SIBO and NAFLD. Three studies and 205 children were included. All three studies reported the association between SIBO and NAFLD. Children with SIBO were more likely to have NAFLD (odds ratio = 5.27, 95% confidence interval (CI): 1.66-16.68, P<0.001; I2 = 63.5%, Pheterogeneity = 0.065). When directly pooling the reported relative risks (RR) from two studies, children with NAFLD had an over 2-fold increased relative risk of developing SIBO (RR = 2.17, 05%CI: 1.66-2.82, P<0.001; I2 = 0.0%, Pheterogeneity = 0.837). This meta-analysis reports a possible association between SIBO and NAFLD in children. |
| first_indexed | 2024-12-18T04:18:19Z |
| format | Article |
| id | doaj.art-b2ab4d04f07e4cd4bc3aaa983171a7da |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-18T04:18:19Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b2ab4d04f07e4cd4bc3aaa983171a7da2022-12-21T21:21:18ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-011612e026047910.1371/journal.pone.0260479Association of small intestinal bacterial overgrowth with nonalcoholic fatty liver disease in children: A meta-analysis.Linghan KuangWei ZhouYongmei JiangIt has been suggested that small intestinal bacterial overgrowth (SIBO) could cause nonalcoholic fatty liver disease (NAFLD), but this association was not examined in children by meta-analysis. This meta-analysis aimed to determine the association between SIBO and NAFLD in children. The electronic databases PubMed, Embase, and Cochrane Library were searched for studies published before April 22, 2021. The outcome was the association between SIBO and NAFLD. Three studies and 205 children were included. All three studies reported the association between SIBO and NAFLD. Children with SIBO were more likely to have NAFLD (odds ratio = 5.27, 95% confidence interval (CI): 1.66-16.68, P<0.001; I2 = 63.5%, Pheterogeneity = 0.065). When directly pooling the reported relative risks (RR) from two studies, children with NAFLD had an over 2-fold increased relative risk of developing SIBO (RR = 2.17, 05%CI: 1.66-2.82, P<0.001; I2 = 0.0%, Pheterogeneity = 0.837). This meta-analysis reports a possible association between SIBO and NAFLD in children.https://doi.org/10.1371/journal.pone.0260479 |
| spellingShingle | Linghan Kuang Wei Zhou Yongmei Jiang Association of small intestinal bacterial overgrowth with nonalcoholic fatty liver disease in children: A meta-analysis. PLoS ONE |
| title | Association of small intestinal bacterial overgrowth with nonalcoholic fatty liver disease in children: A meta-analysis. |
| title_full | Association of small intestinal bacterial overgrowth with nonalcoholic fatty liver disease in children: A meta-analysis. |
| title_fullStr | Association of small intestinal bacterial overgrowth with nonalcoholic fatty liver disease in children: A meta-analysis. |
| title_full_unstemmed | Association of small intestinal bacterial overgrowth with nonalcoholic fatty liver disease in children: A meta-analysis. |
| title_short | Association of small intestinal bacterial overgrowth with nonalcoholic fatty liver disease in children: A meta-analysis. |
| title_sort | association of small intestinal bacterial overgrowth with nonalcoholic fatty liver disease in children a meta analysis |
| url | https://doi.org/10.1371/journal.pone.0260479 |
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