Determinants of tumor necrosis and its impact on outcome in patients with Localized osteosarcoma uniformly treated with a response adapted regimen without high dose Methotrexate– A retrospective institutional analysis

Determinants of tumor necrosis and its impact on outcome in patients with Localized osteosarcoma uniformly treated with a response adapted regimen without high dose Methotrexate– A retrospective institutional analysis

Purpose: Response to neoadjuvant chemotherapy in form of tumor necrosis predicts outcome in osteosarcoma; although response-adapted treatment escalation failed to improve outcome among patients treated with high-dose methotrexate-based (HDMTx) chemotherapy. This study aimed to identify factors predi...

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Bibliographic Details
Main Authors: Prabhat Gautam Roy, Shuvadeep Ganguly, Archana Sasi, Vivek Kumar, Adarsh Barwad, Asit Ranjan Mridha, Shah Alam Khan, Venkatesan Sampath Kumar, Love Kapoor, Deepam Pushpam, Sameer Bakhshi
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Journal of Bone Oncology
Subjects:
Osteosarcoma
Tumour Necrosis
Non-High Dose Methotrexate regimen
Prognosis
Neoadjuvant Chemotherapy
Response adapted Adjuvant chemotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2212137424001313

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http://www.sciencedirect.com/science/article/pii/S2212137424001313

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