Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner
Abstract A new prototype spectral photon-counting computed tomography (SPCCT) based on a modified clinical CT system has been developed. SPCCT analysis of the energy composition of the transmitted x-ray spectrum potentially allows simultaneous dual contrast agent imaging, however, this has not yet b...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-04659-9 |
| _version_ | 1830145374158848000 |
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| author | David P. Cormode Salim Si-Mohamed Daniel Bar-Ness Monica Sigovan Pratap C. Naha Joelle Balegamire Franck Lavenne Philippe Coulon Ewald Roessl Matthias Bartels Michal Rokni Ira Blevis Loic Boussel Philippe Douek |
| author_facet | David P. Cormode Salim Si-Mohamed Daniel Bar-Ness Monica Sigovan Pratap C. Naha Joelle Balegamire Franck Lavenne Philippe Coulon Ewald Roessl Matthias Bartels Michal Rokni Ira Blevis Loic Boussel Philippe Douek |
| author_sort | David P. Cormode |
| collection | DOAJ |
| description | Abstract A new prototype spectral photon-counting computed tomography (SPCCT) based on a modified clinical CT system has been developed. SPCCT analysis of the energy composition of the transmitted x-ray spectrum potentially allows simultaneous dual contrast agent imaging, however, this has not yet been demonstrated with such a system. We investigated the feasibility of using this system to distinguish gold nanoparticles (AuNP) and an iodinated contrast agent. The contrast agents and calcium phosphate were imaged in phantoms. Conventional CT, gold K-edge, iodine and water images were produced and demonstrated accurate discrimination and quantification of gold and iodine concentrations in a phantom containing mixtures of the contrast agents. In vivo experiments were performed using New Zealand White rabbits at several times points after injections of AuNP and iodinated contrast agents. We found that the contrast material maps clearly differentiated the distributions of gold and iodine in the tissues allowing quantification of the contrast agents’ concentrations, which matched their expected pharmacokinetics. Furthermore, rapid, repetitive scanning was done, which allowed measurement of contrast agent kinetics with high temporal resolution. In conclusion, a clinical scale, high count rate SPCCT system is able to discriminate gold and iodine contrast media in different organs in vivo. |
| first_indexed | 2024-12-17T10:22:53Z |
| format | Article |
| id | doaj.art-b2ae545bf47442cdb66177ce98cd2d81 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-17T10:22:53Z |
| publishDate | 2017-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-b2ae545bf47442cdb66177ce98cd2d812022-12-21T21:52:45ZengNature PortfolioScientific Reports2045-23222017-07-017111110.1038/s41598-017-04659-9Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scannerDavid P. Cormode0Salim Si-Mohamed1Daniel Bar-Ness2Monica Sigovan3Pratap C. Naha4Joelle Balegamire5Franck Lavenne6Philippe Coulon7Ewald Roessl8Matthias Bartels9Michal Rokni10Ira Blevis11Loic Boussel12Philippe Douek13Department of Radiology, University of PennsylvaniaRadiology Department, Hospices Civils de LyonRadiology Department, Hospices Civils de LyonRadiology Department, Hospices Civils de LyonDepartment of Radiology, University of PennsylvaniaLAGEP Laboratory, University Lyon 1 Claude BernardCERMEPCT Clinical SciencePhilips GmbH Innovative Technologies, Research LaboratoriesPhilips GmbH Innovative Technologies, Research LaboratoriesGlobal Advanced Technologies, CTGlobal Advanced Technologies, CTRadiology Department, Hospices Civils de LyonRadiology Department, Hospices Civils de LyonAbstract A new prototype spectral photon-counting computed tomography (SPCCT) based on a modified clinical CT system has been developed. SPCCT analysis of the energy composition of the transmitted x-ray spectrum potentially allows simultaneous dual contrast agent imaging, however, this has not yet been demonstrated with such a system. We investigated the feasibility of using this system to distinguish gold nanoparticles (AuNP) and an iodinated contrast agent. The contrast agents and calcium phosphate were imaged in phantoms. Conventional CT, gold K-edge, iodine and water images were produced and demonstrated accurate discrimination and quantification of gold and iodine concentrations in a phantom containing mixtures of the contrast agents. In vivo experiments were performed using New Zealand White rabbits at several times points after injections of AuNP and iodinated contrast agents. We found that the contrast material maps clearly differentiated the distributions of gold and iodine in the tissues allowing quantification of the contrast agents’ concentrations, which matched their expected pharmacokinetics. Furthermore, rapid, repetitive scanning was done, which allowed measurement of contrast agent kinetics with high temporal resolution. In conclusion, a clinical scale, high count rate SPCCT system is able to discriminate gold and iodine contrast media in different organs in vivo.https://doi.org/10.1038/s41598-017-04659-9 |
| spellingShingle | David P. Cormode Salim Si-Mohamed Daniel Bar-Ness Monica Sigovan Pratap C. Naha Joelle Balegamire Franck Lavenne Philippe Coulon Ewald Roessl Matthias Bartels Michal Rokni Ira Blevis Loic Boussel Philippe Douek Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner Scientific Reports |
| title | Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner |
| title_full | Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner |
| title_fullStr | Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner |
| title_full_unstemmed | Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner |
| title_short | Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner |
| title_sort | multicolor spectral photon counting computed tomography in vivo dual contrast imaging with a high count rate scanner |
| url | https://doi.org/10.1038/s41598-017-04659-9 |
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