Multiple Sclerosis: Enzymatic Cross Site-Specific Hydrolysis of H1 Histone by IgGs against H1, H2A, H2B, H3, H4 Histones, and Myelin Basic Protein

Multiple Sclerosis: Enzymatic Cross Site-Specific Hydrolysis of H1 Histone by IgGs against H1, H2A, H2B, H3, H4 Histones, and Myelin Basic Protein

Histones play a key role in chromatin remodeling and gene transcription. Further, free histones in the blood act as damage-associated molecules. Administration of histones to animals results in systemic inflammatory and toxic effects. Myelin basic protein is the principal constituent element of the...

Full description

Bibliographic Details
Main Authors: Georgy A. Nevinsky, Svetlana V. Baranova, Valentina N. Buneva, Pavel S. Dmitrenok
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Biomolecules
Subjects:
human blood sera antibodies
multiple sclerosis patients
catalytic antibodies-abzymes
hydrolysis of H1 histone
IgGs against H1
H2A
Online Access:https://www.mdpi.com/2218-273X/11/8/1140

Internet

https://www.mdpi.com/2218-273X/11/8/1140

Similar Items