Pathobiological functions and clinical implications of annexin dysregulation in human cancers
Annexins are an extensive superfamily of structurally related calcium- and phospholipid-binding proteins, largely conserved and widely distributed among species. Twelve human annexins have been identified, referred to as Annexin A1-13 (A12 remains as of yet unassigned), whose genes are spread throug...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.1009908/full |
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| author | Llara Prieto-Fernández Llara Prieto-Fernández Sofía T. Menéndez Sofía T. Menéndez María Otero-Rosales Irene Montoro-Jiménez Irene Montoro-Jiménez Francisco Hermida-Prado Francisco Hermida-Prado Juana M. García-Pedrero Juana M. García-Pedrero Saúl Álvarez-Teijeiro Saúl Álvarez-Teijeiro |
| author_facet | Llara Prieto-Fernández Llara Prieto-Fernández Sofía T. Menéndez Sofía T. Menéndez María Otero-Rosales Irene Montoro-Jiménez Irene Montoro-Jiménez Francisco Hermida-Prado Francisco Hermida-Prado Juana M. García-Pedrero Juana M. García-Pedrero Saúl Álvarez-Teijeiro Saúl Álvarez-Teijeiro |
| author_sort | Llara Prieto-Fernández |
| collection | DOAJ |
| description | Annexins are an extensive superfamily of structurally related calcium- and phospholipid-binding proteins, largely conserved and widely distributed among species. Twelve human annexins have been identified, referred to as Annexin A1-13 (A12 remains as of yet unassigned), whose genes are spread throughout the genome on eight different chromosomes. According to their distinct tissue distribution and subcellular localization, annexins have been functionally implicated in a variety of biological processes relevant to both physiological and pathological conditions. Dysregulation of annexin expression patterns and functions has been revealed as a common feature in multiple cancers, thereby emerging as potential biomarkers and molecular targets for clinical application. Nevertheless, translation of this knowledge to the clinic requires in-depth functional and mechanistic characterization of dysregulated annexins for each individual cancer type, since each protein exhibits varying expression levels and phenotypic specificity depending on the tumor types. This review specifically and thoroughly examines the current knowledge on annexin dysfunctions in carcinogenesis. Hence, available data on expression levels, mechanism of action and pathophysiological effects of Annexin A1-13 among different cancers will be dissected, also further discussing future perspectives for potential applications as biomarkers for early diagnosis, prognosis and molecular-targeted therapies. Special attention is devoted to head and neck cancers (HNC), a complex and heterogeneous group of aggressive malignancies, often lately diagnosed, with high mortality, and scarce therapeutic options. |
| first_indexed | 2024-04-12T20:25:23Z |
| format | Article |
| id | doaj.art-b2b17d4e21184b95a6db49572eefbb9d |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-12T20:25:23Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-b2b17d4e21184b95a6db49572eefbb9d2022-12-22T03:17:53ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-09-011010.3389/fcell.2022.10099081009908Pathobiological functions and clinical implications of annexin dysregulation in human cancersLlara Prieto-Fernández0Llara Prieto-Fernández1Sofía T. Menéndez2Sofía T. Menéndez3María Otero-Rosales4Irene Montoro-Jiménez5Irene Montoro-Jiménez6Francisco Hermida-Prado7Francisco Hermida-Prado8Juana M. García-Pedrero9Juana M. García-Pedrero10Saúl Álvarez-Teijeiro11Saúl Álvarez-Teijeiro12Department of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria Del Principado de Asturias (ISPA), Instituto Universitario de Oncología Del Principado de Asturias (IUOPA), University of Oviedo, Oviedo, SpainCIBERONC, Instituto de Salud Carlos III, Madrid, SpainDepartment of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria Del Principado de Asturias (ISPA), Instituto Universitario de Oncología Del Principado de Asturias (IUOPA), University of Oviedo, Oviedo, SpainCIBERONC, Instituto de Salud Carlos III, Madrid, SpainDepartment of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria Del Principado de Asturias (ISPA), Instituto Universitario de Oncología Del Principado de Asturias (IUOPA), University of Oviedo, Oviedo, SpainDepartment of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria Del Principado de Asturias (ISPA), Instituto Universitario de Oncología Del Principado de Asturias (IUOPA), University of Oviedo, Oviedo, SpainCIBERONC, Instituto de Salud Carlos III, Madrid, SpainDepartment of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria Del Principado de Asturias (ISPA), Instituto Universitario de Oncología Del Principado de Asturias (IUOPA), University of Oviedo, Oviedo, SpainCIBERONC, Instituto de Salud Carlos III, Madrid, SpainDepartment of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria Del Principado de Asturias (ISPA), Instituto Universitario de Oncología Del Principado de Asturias (IUOPA), University of Oviedo, Oviedo, SpainCIBERONC, Instituto de Salud Carlos III, Madrid, SpainDepartment of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria Del Principado de Asturias (ISPA), Instituto Universitario de Oncología Del Principado de Asturias (IUOPA), University of Oviedo, Oviedo, SpainCIBERONC, Instituto de Salud Carlos III, Madrid, SpainAnnexins are an extensive superfamily of structurally related calcium- and phospholipid-binding proteins, largely conserved and widely distributed among species. Twelve human annexins have been identified, referred to as Annexin A1-13 (A12 remains as of yet unassigned), whose genes are spread throughout the genome on eight different chromosomes. According to their distinct tissue distribution and subcellular localization, annexins have been functionally implicated in a variety of biological processes relevant to both physiological and pathological conditions. Dysregulation of annexin expression patterns and functions has been revealed as a common feature in multiple cancers, thereby emerging as potential biomarkers and molecular targets for clinical application. Nevertheless, translation of this knowledge to the clinic requires in-depth functional and mechanistic characterization of dysregulated annexins for each individual cancer type, since each protein exhibits varying expression levels and phenotypic specificity depending on the tumor types. This review specifically and thoroughly examines the current knowledge on annexin dysfunctions in carcinogenesis. Hence, available data on expression levels, mechanism of action and pathophysiological effects of Annexin A1-13 among different cancers will be dissected, also further discussing future perspectives for potential applications as biomarkers for early diagnosis, prognosis and molecular-targeted therapies. Special attention is devoted to head and neck cancers (HNC), a complex and heterogeneous group of aggressive malignancies, often lately diagnosed, with high mortality, and scarce therapeutic options.https://www.frontiersin.org/articles/10.3389/fcell.2022.1009908/fullannexinhead and neck cancerbiomarkerdiagnosistherapeutic target |
| spellingShingle | Llara Prieto-Fernández Llara Prieto-Fernández Sofía T. Menéndez Sofía T. Menéndez María Otero-Rosales Irene Montoro-Jiménez Irene Montoro-Jiménez Francisco Hermida-Prado Francisco Hermida-Prado Juana M. García-Pedrero Juana M. García-Pedrero Saúl Álvarez-Teijeiro Saúl Álvarez-Teijeiro Pathobiological functions and clinical implications of annexin dysregulation in human cancers Frontiers in Cell and Developmental Biology annexin head and neck cancer biomarker diagnosis therapeutic target |
| title | Pathobiological functions and clinical implications of annexin dysregulation in human cancers |
| title_full | Pathobiological functions and clinical implications of annexin dysregulation in human cancers |
| title_fullStr | Pathobiological functions and clinical implications of annexin dysregulation in human cancers |
| title_full_unstemmed | Pathobiological functions and clinical implications of annexin dysregulation in human cancers |
| title_short | Pathobiological functions and clinical implications of annexin dysregulation in human cancers |
| title_sort | pathobiological functions and clinical implications of annexin dysregulation in human cancers |
| topic | annexin head and neck cancer biomarker diagnosis therapeutic target |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.1009908/full |
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