A Novel PBM for Nanomilling of Drugs in a Recirculating Wet Stirred Media Mill: Impacts of Batch Size, Flow Rate, and Back-Mixing

A Novel PBM for Nanomilling of Drugs in a Recirculating Wet Stirred Media Mill: Impacts of Batch Size, Flow Rate, and Back-Mixing

We examined the evolution of fenofibrate (FNB, drug) particle size distribution (PSD) during the production of nanosuspensions via wet stirred media milling (WSMM) with a cell-based population balance model (PBM). Our objective was to elucidate the potential impacts of batch size, suspension volumet...

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Bibliographic Details
Main Authors: Hamidreza Heidari, Nontawat Muanpaopong, Gulenay Guner, Helen F. Yao, Donald J. Clancy, Ecevit Bilgili
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Pharmaceutics
Subjects:
wet stirred media milling
population balance model
drug nanoparticles
breakage kinetics
process development
imperfect mixing
Online Access:https://www.mdpi.com/1999-4923/16/3/353

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